Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of Cardiotonic Activity of some Traditionally Used Medicinal Plants


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1 Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India
     

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The present study was undertaken to evaluate the cardiotonic activity of the aqueous, methanolic and chloroform extracts of the ischolar_mains of Hemidesmus indicus and fruits of Terminalia bellirica, Terminalia chebula. The cardiotonic effect of aqueous, methanolic and chloroform extracts of the three plants was studied by using isolated frog heart perfusion technique (IFHP). Ringer solution without calcium was used as a vehicle for administration of aqueous, methanolic and chloroform extracts as test and digoxin as standard. A significant increase in the height of force of contraction (positive ionotropic effect) and decrease in heart rate (negative chronotropic effect) was observed and as compared to standard, test drug showed wide therapeutic index.

Keywords

Cardiotinic Activity, Frog Heart Perfusion Technique, Digoxin, Therapeutic Index,Hemidesmus Indicus, Terminalia Bellirica, Terminalia Chebula
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  • Evaluation of Cardiotonic Activity of some Traditionally Used Medicinal Plants

Abstract Views: 469  |  PDF Views: 2

Authors

K. Sanjeev Kumar
Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India
V. Vijay Kumar
Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India
A. G. Prasanthi
Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India
L. K. Kanthal
Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India
P. Bhoja Raju
Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India
K. Satyavathi
Koringa College of Pharmacy, Korangi, Tallarevu (M), East Godavari Dist., Andhra Pradesh, India

Abstract


The present study was undertaken to evaluate the cardiotonic activity of the aqueous, methanolic and chloroform extracts of the ischolar_mains of Hemidesmus indicus and fruits of Terminalia bellirica, Terminalia chebula. The cardiotonic effect of aqueous, methanolic and chloroform extracts of the three plants was studied by using isolated frog heart perfusion technique (IFHP). Ringer solution without calcium was used as a vehicle for administration of aqueous, methanolic and chloroform extracts as test and digoxin as standard. A significant increase in the height of force of contraction (positive ionotropic effect) and decrease in heart rate (negative chronotropic effect) was observed and as compared to standard, test drug showed wide therapeutic index.

Keywords


Cardiotinic Activity, Frog Heart Perfusion Technique, Digoxin, Therapeutic Index,Hemidesmus Indicus, Terminalia Bellirica, Terminalia Chebula

References