Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Anti-Ovulatory and Abortifacient Potential of the Ethanolic Extract of Henna Roots in Rats


Affiliations
1 Department of Pharmacy, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India
     

   Subscribe/Renew Journal


The rise in population in the developing world is over whelming and this intensifies the need for effective birth control measures. The synthetic agents available today for fertility control produce severe side effects. Such as hormonal imbalance, hypertension, increased risk of cancer and weight gain. Thus there is a need to replace these agents by safe and effective agents such as plants based contraceptive agents.

Therefore, the present study was under taken to explore the abotifacient and antiovulatory activity of ethanol extract of henna ischolar_mains. Thus, the successive ethanolic extract showed promising strong abotifacient and antiovulatory activity was observed at dose level of 400mg/kg body weight. Histological studies were carried out to confirm this effect.


Keywords

Abortifacient, Ovulation, Contraception.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Handa G.Kapil A., Sharma S., and Singh J. (1997), Lawnermis acid a new anticomplementary triterpenoid from Lawsonia inermis seeds. Indian J. Chem., Sect. B.36, 252-256.

  • Knecht W., Henseling J., and Loffler M. (2000), Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem. Biol. Interact. 124, 61-76.

  • Wagner H., Kreher B., and Jurcic K. (1988). In vitro stimulation of human granulocytes and lymphocytes by pico- and femtogram quantities of cytostatic agents. Arzneim. Forsch. 38, 273-275.

  • Malekzadeh F. (1968), antimicrobial activity of Lawsonia inermis L. Applied Microbiol 16, 663-664.

  • Abd-el- Malek Y.A., El-Leithy M.A., Reda F.A., and Khalil M. (1973). Antimicrobial principles in leaves of Lawsonia inermis L. Zentralbl. Bakteriol. Parasitenkd Infektionskr Hyg. 128, 61-67.

  • Chang H., and suzuka S.E., (1982). Lawsone (2-OH-1,4-naphthoquinone) derived from the henna plant increases the oxygen affinity of sickle cell blood. Bio-chem. Biophys.Res. Commun. 107, 602-608.

  • Clarke D.T., Jones G.R., and Martin M.M (1986), The anti –sickling drug lawsone (2-OH-1,4–naphtha-quinone) Protects sickled cells against membrane damage, Biochem. Biophys, Res. Commun.139, 780 – 786.

  • Anaad K.K., Singh B., Chand D., and Chandon B.K. (1992). An evaluation of Lawsonia alba extract as hepatoprotective agent. Planta Med. 58, 22-25.

  • Ali M., and Grever M.R. (1998). A cytotoxic naphthoquinone from Lawsonia inermis. Fitoterapia LXIX ( 2 ) ,1810-1813.

  • Ali B H, Bashir A.K., and Tanira M.O. (1995), antiinflammatory, antipyretic, and analgesic effects of Lawsonia inermis L (Henna) in rats. Pharmacology 51, 356-63.

  • Shivalinagappa. H., Satyanaryan. ND., and Purohit. MG. (2001). Antimplantation and pregnancy interruption efficacy of Rivea hypocrateriformis in the rat. J Ethnopharmacol; 74: 245-9.

  • -60. Hafez ES. (1970). Reproduction in breeding techniques for laboratory animals. Philadelphia: Leaand febiger.

  • Medeiros RM., Gorniak SL., and Guerra JL. (2000). Fetotoxicity and Reproductive effects of monocrotaline in pregnant rats. J Ethnopharmacol; 69: 181-8.

  • Feranada CG. Almedia., and Lone P. Lemonica (2000). The toxic effects of Coleus barbatus B on the different periods of pregnancy in rats. J Ethnopharmacol; 73: 53

  • Nath D., Sethi N., Singh RK., and Jain AK. (1992). Commonly used Indian abortifacient plants with special reference to teratologic effects in rats. J. Ethnopharmacol; 36: 147-54.

  • Prakash AO., and Mathur R. (1979). Studies on oestrous cycle of the albino rats: Response to Embelia ribes extracts. Planta Medica; 36: 131-41.

  • Shivalinagppa H., Satyanarayan ND., Purohit MG., Sharanabasappa A., and Patil SB. (2002). Effect of ethanol extract of Rivea hypocrateriformis on the estrous cycle of the rat. J Ethnopharmacol; 82: 11-7.

  • Circosta C., Sanogo E., and Occhiuto F. (2001). Effects of Calotropis procera on oestrous cycle and on oestrogenic functionality in rats. Farmaco; 56: 373-8.


Abstract Views: 357

PDF Views: 0




  • Anti-Ovulatory and Abortifacient Potential of the Ethanolic Extract of Henna Roots in Rats

Abstract Views: 357  |  PDF Views: 0

Authors

S. Rani
Department of Pharmacy, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India
R. Manavalan
Department of Pharmacy, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India
D. Kilimozhi
Department of Pharmacy, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India

Abstract


The rise in population in the developing world is over whelming and this intensifies the need for effective birth control measures. The synthetic agents available today for fertility control produce severe side effects. Such as hormonal imbalance, hypertension, increased risk of cancer and weight gain. Thus there is a need to replace these agents by safe and effective agents such as plants based contraceptive agents.

Therefore, the present study was under taken to explore the abotifacient and antiovulatory activity of ethanol extract of henna ischolar_mains. Thus, the successive ethanolic extract showed promising strong abotifacient and antiovulatory activity was observed at dose level of 400mg/kg body weight. Histological studies were carried out to confirm this effect.


Keywords


Abortifacient, Ovulation, Contraception.

References