Research Journal of Pharmacology and Pharmacodynamics

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Effect of Hexane Extract of Coleus forskohlii on Chemically Induced Liver Damage


Affiliations
1 Department of Pharmacology, East Point College of Pharmacy, Virgonagar Post, Bidarahalli, Bangalore-560 049, India
2 Aurobindo Pharma Ltd, Jadcherla, Mahabub Nagar, Andra Pradesh, India
3 Syngene International Ltd, Biocon Park, Bommasandra IV Phase, Bangalore- 560 099, India
4 East Point College of Pharmacy, Virgonagar Post, Bidarahalli, Bangalore-560 049, India
     

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The hexane extract of Coleus forskohlii (CFHE) was evaluated for its effect on liver injury induced by carbon tetrachloride, paracetamol or thioacetamide. The CFHE was given in two different doses (27.5mg/kg p.o. and 55mg/kg p.o.). Silymarin, a known hepatoprotective agent was used as standard. The lower dose of CFHE (27.5mg/kg p.o.) significantly reduced the elevated levels of serum marker enzymes and prevented the increase in liver weight in all three models of liver injury, while the higher dose showed mild hepatoprotective activity. The hepatoprotective effect of lower dose of CFHE was supported by changes in histopathology. It was concluded that hexane extract of CFHE in lower doses possess hepatoprotective activity.

Keywords

Coleus Forskohlii, Hepatoprotective, Carbon Tetrachloride, Paracetamol, Thioacetamide.
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  • Caprioli J and Sears M. Forskolin lowers intraocular pressure in rabbits, monkeys and man. Lancet 1983; 1: 958-960.

  • Wong S, Mok W and Phaneuf, S. Forskolin inhibits plateletactivating factor binding to platelet receptors independently of adenylyl cyclase activation. Eur J Pharmacol 1993; 245: 55-61.

  • Agarwal KC and Parks RE Jr. Forskolin. Int J Cancer. 1983; 32: 801-804.

  • Bauer K, Dietersdorfer F and Sertl K. Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin Pharmacol Ther 1993; 43: 76-83.

  • Kramer W, Thormann J, Kindler M and Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Arzneim Forsch 1987; 37: 364-7.

  • Health Effect Test Guidelines, Acute Oral Toxicity, [Computer program] OPPTS 870, 1100 United States Office of Prevention, Pesticides and Toxic Substances Environmental Protection Agency (7101). [Available from: URL: http://www.epa.gov/opptsfrs/home/guidelin.htm. 5/6/2004].

  • Matsuda H, Samukawa K and Kubo M. Anti-hepatic activity of Ginsenoside Ro. Planta Med 57 (1991) 523.

  • Asha VV and Pushpangadan P. Preliminary evaluations of the antihepatotoxic activity of Phyllanthus kozhikodianus, P maderaspatensis and Solanum indicum. Fitoterapia LXIX 2 (1998) 135.

  • Ahmad A, Pillai K K, Ahmed S J, Balani D K, Najmi A K, Marwah R and Hameed A, Evaluation of the hepatoprotective potencial of Jingrine pretreatment on thioacetamide induced liver damage in rats. Indian J Pharmacol 31 (1999) 416.

  • Shenoy KA, Somayaji SN and Bairy KL. Hepatoprotective effect of Ginkgo biloba in carbon tetrachloride induced hepatic injury in rats. Indian. J. Pharmacol 2001; 33: 260-266.

  • Udem SC, Madubunyy I, Okoye JOA and Anika SM. Antihepatotoxic effects of the ethanolic extracts of Combretum dolichopetalum ischolar_main bark and Morinda lucida leaf. Fitoterapia 1997; LXVIII, 1:21-25.

  • Kumar G, Sharmila BG, Vanitha P, Sundararjan M and Rajesekara PM. Hepatoprotective acitivity of Trianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats. J Ethnopharmacol 2004; 92: 37-40.

  • Moore AR and Walloughby. The role of cAMP in controlling inflammation.Clin Exp.Immunol 1995; 101:387-389.

  • Pierce NF, Greenough WB and Carpenter CC. Jr. Vibrio cholerae enterotoxin and its mode of action. Bacteriol Rev 1971; 35:1-13.

  • Seamon KB and Daly JW. Forskolin: its biological and chemical properties. Adv Cyclic Nucleotide Protein Phosphorylation Res 1986; 20:1-150.


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  • Effect of Hexane Extract of Coleus forskohlii on Chemically Induced Liver Damage

Abstract Views: 330  |  PDF Views: 2

Authors

Y. Jyothi
Department of Pharmacology, East Point College of Pharmacy, Virgonagar Post, Bidarahalli, Bangalore-560 049, India
Kiran Kumar
Aurobindo Pharma Ltd, Jadcherla, Mahabub Nagar, Andra Pradesh, India
Shashidhar Reddy
Syngene International Ltd, Biocon Park, Bommasandra IV Phase, Bangalore- 560 099, India
Tathagata Dey
East Point College of Pharmacy, Virgonagar Post, Bidarahalli, Bangalore-560 049, India

Abstract


The hexane extract of Coleus forskohlii (CFHE) was evaluated for its effect on liver injury induced by carbon tetrachloride, paracetamol or thioacetamide. The CFHE was given in two different doses (27.5mg/kg p.o. and 55mg/kg p.o.). Silymarin, a known hepatoprotective agent was used as standard. The lower dose of CFHE (27.5mg/kg p.o.) significantly reduced the elevated levels of serum marker enzymes and prevented the increase in liver weight in all three models of liver injury, while the higher dose showed mild hepatoprotective activity. The hepatoprotective effect of lower dose of CFHE was supported by changes in histopathology. It was concluded that hexane extract of CFHE in lower doses possess hepatoprotective activity.

Keywords


Coleus Forskohlii, Hepatoprotective, Carbon Tetrachloride, Paracetamol, Thioacetamide.

References