Research Journal of Pharmacology and Pharmacodynamics

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Effect of Hexane Extract of Coleus forskohlii on Chemically Induced Liver Damage


Affiliations
1 Department of Pharmacology, East Point College of Pharmacy, Virgonagar Post, Bidarahalli, Bangalore-560 049, India
2 Aurobindo Pharma Ltd, Jadcherla, Mahabub Nagar, Andra Pradesh, India
3 Syngene International Ltd, Biocon Park, Bommasandra IV Phase, Bangalore- 560 099, India
4 East Point College of Pharmacy, Virgonagar Post, Bidarahalli, Bangalore-560 049, India
     

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The hexane extract of Coleus forskohlii (CFHE) was evaluated for its effect on liver injury induced by carbon tetrachloride, paracetamol or thioacetamide. The CFHE was given in two different doses (27.5mg/kg p.o. and 55mg/kg p.o.). Silymarin, a known hepatoprotective agent was used as standard. The lower dose of CFHE (27.5mg/kg p.o.) significantly reduced the elevated levels of serum marker enzymes and prevented the increase in liver weight in all three models of liver injury, while the higher dose showed mild hepatoprotective activity. The hepatoprotective effect of lower dose of CFHE was supported by changes in histopathology. It was concluded that hexane extract of CFHE in lower doses possess hepatoprotective activity.

Keywords

Coleus Forskohlii, Hepatoprotective, Carbon Tetrachloride, Paracetamol, Thioacetamide.
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  • Effect of Hexane Extract of Coleus forskohlii on Chemically Induced Liver Damage

Abstract Views: 334  |  PDF Views: 2

Authors

Y. Jyothi
Department of Pharmacology, East Point College of Pharmacy, Virgonagar Post, Bidarahalli, Bangalore-560 049, India
Kiran Kumar
Aurobindo Pharma Ltd, Jadcherla, Mahabub Nagar, Andra Pradesh, India
Shashidhar Reddy
Syngene International Ltd, Biocon Park, Bommasandra IV Phase, Bangalore- 560 099, India
Tathagata Dey
East Point College of Pharmacy, Virgonagar Post, Bidarahalli, Bangalore-560 049, India

Abstract


The hexane extract of Coleus forskohlii (CFHE) was evaluated for its effect on liver injury induced by carbon tetrachloride, paracetamol or thioacetamide. The CFHE was given in two different doses (27.5mg/kg p.o. and 55mg/kg p.o.). Silymarin, a known hepatoprotective agent was used as standard. The lower dose of CFHE (27.5mg/kg p.o.) significantly reduced the elevated levels of serum marker enzymes and prevented the increase in liver weight in all three models of liver injury, while the higher dose showed mild hepatoprotective activity. The hepatoprotective effect of lower dose of CFHE was supported by changes in histopathology. It was concluded that hexane extract of CFHE in lower doses possess hepatoprotective activity.

Keywords


Coleus Forskohlii, Hepatoprotective, Carbon Tetrachloride, Paracetamol, Thioacetamide.

References