Research Journal of Pharmacology and Pharmacodynamics

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Antiulcer Activity of Colebrookea oppositifolia Sm


Affiliations
1 Indira College of Pharmacy, Tathwade, Pune 411 033, India
2 Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Dept. of Pharmacology, Pimpri, Pune-18 (Maharashtra), India
3 BVDU Medical College and Hospital, Sangli, India
     

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In the present study, the antiulcer activity of hydroalcoholic extract of ischolar_mains of Colebrookea oppositifolia Sm. (CO) was evaluated in ethanol and swim stress induced peptic ulcer models. In both the models, various parameters like ulcer index, percentage protection, gastric wall mucus, catalase, reduced glutathione (GSH), lipid peroxidation (LPO) and superoxide dismutase (SOD) were estimated. CO significantly reduced the ulcer index and increased the gastric wall mucus in both the models. CO showed significant antioxidant activity as indicated by significant decrease in LPO and increase in catalase, GSH and SOD levels in stomach tissue homogenate. The results suggest that hydroalcoholic extract of ischolar_mains of Colebrookea oppositifolia possess antiulcer activity due to its mucoprotective action and antioxidant potential.

Keywords

Antiulcer, Colebrookea oppositifolia, Antioxidant.
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  • Antiulcer Activity of Colebrookea oppositifolia Sm

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Authors

M. M. Ghaisas
Indira College of Pharmacy, Tathwade, Pune 411 033, India
Surbhi Sharma
Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Dept. of Pharmacology, Pimpri, Pune-18 (Maharashtra), India
G. P. Ganu
Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Dept. of Pharmacology, Pimpri, Pune-18 (Maharashtra), India
R. P. Limaye
BVDU Medical College and Hospital, Sangli, India

Abstract


In the present study, the antiulcer activity of hydroalcoholic extract of ischolar_mains of Colebrookea oppositifolia Sm. (CO) was evaluated in ethanol and swim stress induced peptic ulcer models. In both the models, various parameters like ulcer index, percentage protection, gastric wall mucus, catalase, reduced glutathione (GSH), lipid peroxidation (LPO) and superoxide dismutase (SOD) were estimated. CO significantly reduced the ulcer index and increased the gastric wall mucus in both the models. CO showed significant antioxidant activity as indicated by significant decrease in LPO and increase in catalase, GSH and SOD levels in stomach tissue homogenate. The results suggest that hydroalcoholic extract of ischolar_mains of Colebrookea oppositifolia possess antiulcer activity due to its mucoprotective action and antioxidant potential.

Keywords


Antiulcer, Colebrookea oppositifolia, Antioxidant.

References