Research Journal of Pharmacology and Pharmacodynamics

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Antiulcer Activity of Colebrookea oppositifolia Sm


Affiliations
1 Indira College of Pharmacy, Tathwade, Pune 411 033, India
2 Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Dept. of Pharmacology, Pimpri, Pune-18 (Maharashtra), India
3 BVDU Medical College and Hospital, Sangli, India
     

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In the present study, the antiulcer activity of hydroalcoholic extract of ischolar_mains of Colebrookea oppositifolia Sm. (CO) was evaluated in ethanol and swim stress induced peptic ulcer models. In both the models, various parameters like ulcer index, percentage protection, gastric wall mucus, catalase, reduced glutathione (GSH), lipid peroxidation (LPO) and superoxide dismutase (SOD) were estimated. CO significantly reduced the ulcer index and increased the gastric wall mucus in both the models. CO showed significant antioxidant activity as indicated by significant decrease in LPO and increase in catalase, GSH and SOD levels in stomach tissue homogenate. The results suggest that hydroalcoholic extract of ischolar_mains of Colebrookea oppositifolia possess antiulcer activity due to its mucoprotective action and antioxidant potential.

Keywords

Antiulcer, Colebrookea oppositifolia, Antioxidant.
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  • Dharmani P et al. Ulcer healing effect of anti-ulcer agents: A comparative study. The internet journal of academic physician assistants 2003; 2: 3.

  • Chaturvedi A et al. Effect of ethanolic extract of Eugenia jambolana seeds on gastric ulceration and secretion in rats. Indian J Physiol Pharmacol. 2007; 51: 131-140.

  • The Wealth of India, A Dictionary of Indian Raw Materials and Industrial Products, First supplement series (Raw material). National institute of science and communication, New Delhi, 2001; 2:153-154.

  • Agarwal VS, Ghosh B. Drug plants of India ischolar_main drugs. Kalyani publishers, New Delhi; 1985: 75.

  • Gupta RS et al. Antifertility studies of Colebrookea oppositifolia leaf extract in male rats with special reference to testicular cell population dynamics. Fitoterapia 2001, 72, 236-245.

  • Kirtikar KR, Basu BD. Indian Medicinal plants. Bishen singh and mahendra pal singh, Dehradun 1987; 1977-1978.

  • Manandhar NP. An inventory of some herbal drugs of myagdi district, Nepal. Economic Botany 1995; 49: 371-379.

  • Jana SK, Chauhan AS. Studies on the lepcha medicobotany of Dzangu in the Sikkim Himalaya. Himalayan Paryavaran 1998; 6: 116-121.

  • Kaushik P, Dhiman AK. Medicinal Plants and raw drugs of India. Bishen singh and mahendra pal singh, Dehradun 2000; 441-442.

  • Manandhar NP. Plants and people of Nepal. Timber press, Oregon 2002; 165.

  • Verma S, Chauhan NS. Indigenous medicinal plants knowledge of Kunihar forest division, District Solan. Indian journal of traditional knowledge 2007; 3:494-497.

  • Yang F et al. Flavonoid Glycosides from Colebrookea oppositifolia. Phytochemistry 1996; 42: 867-869.

  • Madhavan V et al. Wound healing activity of aqueous and alcohol extracts of leaves of Colebrookea oppositifolia smith. Indian Drugs 2009; 46: 209-213.

  • Sharma RN et al. Bioacivity of Lamiaceae plants against insects. Indian Journal of Experimental Biology 1992; 30: 244-246.

  • Qazi GN et al., in-ventors, 2006 Jan 24. Hepatoprotective Agent of plant Origin and process thereof. Counsil of Scientific and Industrial research, (assignee). US Patent 6,989,162 B2.

  • Dash S et al. Effect of Aqueous extract Of Colebrookea oppositifolia on Bioavailability of Amoxycilline in Rabbits. Indian Drugs 2004; 414: 231-235.

  • Ahmad SA et al. Flavones from colebrookia opositifolia. Indian journal of chemistry 1975; 12: 1327-1338.

  • Reddy RVN et al. A new acylated flavone glycoside from Colebrookea oppositifolia. Journal of Asian Natural Products Research 2009; 11: 183-186.

  • Rastogi RP, Mehrortra BN. Compedium of Indian Medicinal plants. Publication and Information Directorate, New Delhi, CDRI, Lucknow, 193.

  • Tyagi S et al. Chemical examination of some medicinal plants of shiwalik hills. Himalayan chemical and pharmaceutical Bulletin1994; 11: 4-6.

  • Khandelwal KR. Practical pharmacognosy techniques and experiments. Nirali Prakashan, pune 2005.

  • Organisation for Economic Cooperation and Development (OECD). OECD Guidelines for Testing of Chemicals. Acute Oral Toxicity-Up-and-Down Procedure. OECD, No. 425, 2001.

  • Sairam K et al. Antiulcerogenic effect of methanolic extract of Emblica officinalis: an experimental study. Journal of Ethnopharmacology 2002; 82: 1-9.

  • Suzuki Y et al. Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminom ethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats. Japan Journal of Pharmacology 1976; 26: 471-480.

  • Umamaheswari M et al. Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum. Journal of Ethnopharmacology 2007; 110: 464-470.

  • Jafri MA et al. Evaluation of the gastric antiulcerogenic effect of large cardamom (fruits of Amomum subulatum Roxb). Journal of Ethnopharmacology 2001; 75: 89-94.

  • Lowry OH et al. Protein measurement with the folin phenol reagent. J. Biol. Chem.1951; 193:265-275.

  • Balaraman R et al. Antioxidant activity of DHC-1 - a herbal formulation. Journal of Ethnopharmacology 2004 94, 135-141.

  • Grover JK et al. Extracts of Benincasa hispida prevent development of experimental ulcers. Journal of Ethnopharmacology 2001; 78: 159-164.

  • Nguelefack TB et al. Anti-ulcerogenic properties of the aqueous and methanol extract from the leaves of Solanum torvum Swartz (Solanaceae) in rats. Journal of Ethnopharmacology 2008; 119: 135-140.

  • Goel RK, Maiti RN. Role of endogenous eicosanoids in the antiulcer effect of kaempferol. Fitoterapia 1996 LXVII, 6, 548-552.

  • Barbastefano V et al. Vernonia polyanthes as a new source of antiulcer drugs. Fitoterepia 2007 78, 545-551.

  • Repetto MG, Llesuy SF. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Brazilian Journal of Medical and Biological Research 2002; 35: 523-534.

  • Shah PJ et al. Study of Mimusops elengi bark in experimental gastric ulcers. Journal of Ethnopharmacology 2003; 89: 305-311.

  • Cadirci E et al. Effects of Onosma armeniacum ischolar_main extract on ethanol-induced oxidative stress in stomach tissue of rats. Chemico-Biological Interactions 2007; 170: 40-48.

  • Shine VJ et al. Gastric antisecretory and antiulcer activities of Cyclea peltata (Lam.) Hook. f. & Thoms. in rats. Journal of Ethnopharmacology 2009, (article in press) xxx, xxx-xxx.

  • Jainu M, Devi CSS. Antiulcerogenic and ulcer healing effects of solanum nigrum (L.) on experimental ulcer models: Possible mechanism for the inhibition of acid formation.Journal of ethnopharmacology 2006; 104:156-163.

  • Havsteen BH. The biochemistry and medical significance of the flavonoids. Pharmacology & Therapeutics 2002; 96: 67-202.

  • Maity P et al. The use of neem for controlling gastric hyperacidity and ulcer. Phytotherapy research 2009; 23:747-755.


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  • Antiulcer Activity of Colebrookea oppositifolia Sm

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Authors

M. M. Ghaisas
Indira College of Pharmacy, Tathwade, Pune 411 033, India
Surbhi Sharma
Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Dept. of Pharmacology, Pimpri, Pune-18 (Maharashtra), India
G. P. Ganu
Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Dept. of Pharmacology, Pimpri, Pune-18 (Maharashtra), India
R. P. Limaye
BVDU Medical College and Hospital, Sangli, India

Abstract


In the present study, the antiulcer activity of hydroalcoholic extract of ischolar_mains of Colebrookea oppositifolia Sm. (CO) was evaluated in ethanol and swim stress induced peptic ulcer models. In both the models, various parameters like ulcer index, percentage protection, gastric wall mucus, catalase, reduced glutathione (GSH), lipid peroxidation (LPO) and superoxide dismutase (SOD) were estimated. CO significantly reduced the ulcer index and increased the gastric wall mucus in both the models. CO showed significant antioxidant activity as indicated by significant decrease in LPO and increase in catalase, GSH and SOD levels in stomach tissue homogenate. The results suggest that hydroalcoholic extract of ischolar_mains of Colebrookea oppositifolia possess antiulcer activity due to its mucoprotective action and antioxidant potential.

Keywords


Antiulcer, Colebrookea oppositifolia, Antioxidant.

References