Research Journal of Pharmacology and Pharmacodynamics

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Chemopreventive Potential of Aegle marmelos Fruit Extract against 7,12-dimethylbenz(a)Anthracene-Induced Skin Papillomagenesis in Mice


Affiliations
1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), India
2 Deptt. of Biosciences, Barkatullah University, Bhopal (MP), India
3 Columbia Institute of Pharmacy, Raipur, India
     

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The present investigation was undertaken to explore the chemopreventive action of Aegle marmelos fruit extract on 2-stage carcinogenesis, induced by a single topical application of 7, 12-Dimethylbenz(a)anthracene (DMBA) (104μg/100μl acetone), and one week later, promoted by repeated application of croton oil (1% in acetone/twice in a week) till the end of the experiment (16 weeks) in Swiss albino mice. Single topical application of Aegle marmelos fruit extract at a dose of 900 mg/kg b.w. along with DMBA+Croton oil was found to be effective in decreasing the cumulative number of papillomas, tumor incidence, tumor yield and tumor burden as compared to control group (p<0.05). The depleted levels of glutathione were also restored in Aegle marmelos fruit extract treated group. Thus, the present study revealed the chemopreventive role of Aegle marmelos fruit extracts against DMBA-induced skin carcinogenesis in mice.

Keywords

Chemopreventive, Aegle marmelos, DMBA, Papilloma, Skin Carcinogenesis, Glutathione.
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  • Chemopreventive Potential of Aegle marmelos Fruit Extract against 7,12-dimethylbenz(a)Anthracene-Induced Skin Papillomagenesis in Mice

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Authors

Nirmala Gupta
Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), India
R. C. Agrawal
Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), India
Vinoy Shrivastava
Deptt. of Biosciences, Barkatullah University, Bhopal (MP), India
Amit Roy
Columbia Institute of Pharmacy, Raipur, India
Pushpa Prasad
Columbia Institute of Pharmacy, Raipur, India

Abstract


The present investigation was undertaken to explore the chemopreventive action of Aegle marmelos fruit extract on 2-stage carcinogenesis, induced by a single topical application of 7, 12-Dimethylbenz(a)anthracene (DMBA) (104μg/100μl acetone), and one week later, promoted by repeated application of croton oil (1% in acetone/twice in a week) till the end of the experiment (16 weeks) in Swiss albino mice. Single topical application of Aegle marmelos fruit extract at a dose of 900 mg/kg b.w. along with DMBA+Croton oil was found to be effective in decreasing the cumulative number of papillomas, tumor incidence, tumor yield and tumor burden as compared to control group (p<0.05). The depleted levels of glutathione were also restored in Aegle marmelos fruit extract treated group. Thus, the present study revealed the chemopreventive role of Aegle marmelos fruit extracts against DMBA-induced skin carcinogenesis in mice.

Keywords


Chemopreventive, Aegle marmelos, DMBA, Papilloma, Skin Carcinogenesis, Glutathione.

References