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Effect of Superoxide Dismutase Mimetic Tempol on Dexamethasone Induced Insulin Resistance- Role of Oxidative Stress
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Glucocorticoids like Dexamethasone are widely used Immunosuppressant and Anti-inflammatory agent. They have several adverse effects, majorly Insulin Resistance (IR) and Hypertension these are probably attributed to Oxidative Stress. In the present study, effect of SOD Mimetic Tempol (2,2,6,6,-tetramethyl-4-hydroxy-1-piperidinyloxy) was administered (1mmol/L) for Prophylactic as well as Therapeutic regimen in Experimental Induced Insulin Resistance in male Wister rats by using Dexamethasone (20μg/kg) subcutaneously and estimated Plasma Insulin and TBARS were measured in Plasma as well in isolated Aortic tissue as a marker of Oxidative Stress. HOMA-IR index and Mastuda Index were calculated as an Insulin Resistance/ Insulin Sensitivity. From the finding of present study, Tempol failed to produce any effect on IR so in conclusion, Oxidative Stress may be playing the Initiative role in Dexamethasone Induced IR.
Keywords
Insulin Resistance (IR), Oxidative Stress, Dexamethasone, Insulin Resistance Index (Homa- IR) And Insulin Sensitivity Index (Mastuda Index).
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- Bjelakovic G, Beninati S, Pavlovic D., Glucocorticoids and oxidative stress,18(2): 115-27(2007).
- Xi L, Qian Z, Shen X, Wen N, Zhang Y, Crocetin prevents dexamethasone-induced insulin resistance in rats. Planta Med. 71(10): 917-22 (2005).
- Ogihara T, Asano T, Ando K, Yuko C, Sakoda H, Anai M, Shojima N, Angiotensin II–Induced Insulin Resistance Is Associated With Enhanced Insulin Signaling. Hypertension, 40: 872-79 (2002).
- Rhee MS, Perianayagam A, Chen P, Youn JH, Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol Cell Physiol, 287:1229–37 (2004).
- Britt E, Mette YD, Mulvany MJ, The superoxide dismutasemimetic, Tempol blunts right ventricular hypertrophy in chronic hypoxic rats, B J P, 141: 105–13 (2004).
- Loraine JA, .Bell ET. Hormone assay and their clinical application. 4th ed. New York: Churchill livingstone. (1976).
- Buccolo G, David H. Quantitative determination of serum triglycerides by use of Enzymes. Clin Chem, 19:476-82 (1973).
- Henry RR. Insulin resistance: from predisposing factor to therapeutic target in type 2 diabetes. Clin Ther, 25(B): B47-63 (2003).
- Albareda M, Espinosa JR, Murugo M, Leiva A, Corocoy R. Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test. Diabetol, 43: 4507-11(2000).
- Stojanovska L, Rosella G and Proietto J. Evolution of dexamethasone-induced insulin resistance in rats. Am J Physiol, 258: 748–56 (1990).
- Marwaha A, Mustafa F. Tempol reduces oxidative stress and restores renal dopamine D1-like receptor-G protein coupling and function in hyperglycemic rats. Am J Physiol Renal Physiol, 291: F58–66 (2006).
- Ogihara T et al. Angiotensin II–Induced Insulin Resistance Is Associated With Enhanced Insulin Signaling. Hypertension, 40: 872-79(2002).
- Yu W, Xu A, Ye J, Edward W et al. Alteration in Phosphorylation of P20 Is Associated With Insulin Resistance. Diabetes, 50: 1821–27 (2001).
- Henry RR. Insulin resistance: from predisposing factor to therapeutic target in type 2 diabetes. Clin Ther, 25(B): B47-63 (2003).
- Samy I, Mc F, Banerji M, and James RS. Insulin Resistance and Cardiovascular Disease. J Clini Endocrin Metabol, 86(2): 713- 18 (2001).
- Denis J. Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes, 51(1): 7-18(2002).
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