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Effect of Superoxide Dismutase Mimetic Tempol on Dexamethasone Induced Insulin Resistance- Role of Oxidative Stress


Affiliations
1 R.R.K.S College of Pharmacy, Bidar, Karnataka., India
2 S.V.E.T College of Pharmacy, Humnabad, Bidar Karnataka, India
3 Karnataka College of Pharmacy, Bidar Karnataka, India
     

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Glucocorticoids like Dexamethasone are widely used Immunosuppressant and Anti-inflammatory agent. They have several adverse effects, majorly Insulin Resistance (IR) and Hypertension these are probably attributed to Oxidative Stress. In the present study, effect of SOD Mimetic Tempol (2,2,6,6,-tetramethyl-4-hydroxy-1-piperidinyloxy) was administered (1mmol/L) for Prophylactic as well as Therapeutic regimen in Experimental Induced Insulin Resistance in male Wister rats by using Dexamethasone (20μg/kg) subcutaneously and estimated Plasma Insulin and TBARS were measured in Plasma as well in isolated Aortic tissue as a marker of Oxidative Stress. HOMA-IR index and Mastuda Index were calculated as an Insulin Resistance/ Insulin Sensitivity. From the finding of present study, Tempol failed to produce any effect on IR so in conclusion, Oxidative Stress may be playing the Initiative role in Dexamethasone Induced IR.

Keywords

Insulin Resistance (IR), Oxidative Stress, Dexamethasone, Insulin Resistance Index (Homa- IR) And Insulin Sensitivity Index (Mastuda Index).
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  • Effect of Superoxide Dismutase Mimetic Tempol on Dexamethasone Induced Insulin Resistance- Role of Oxidative Stress

Abstract Views: 247  |  PDF Views: 2

Authors

Karnakumar V. Biradar
R.R.K.S College of Pharmacy, Bidar, Karnataka., India
Chandrashekhar B. Patil
R.R.K.S College of Pharmacy, Bidar, Karnataka., India
Basavaraj V. Chivde
S.V.E.T College of Pharmacy, Humnabad, Bidar Karnataka, India
M. H. Malipatil
Karnataka College of Pharmacy, Bidar Karnataka, India
Sanjivkumar D. Biradar
R.R.K.S College of Pharmacy, Bidar, Karnataka., India

Abstract


Glucocorticoids like Dexamethasone are widely used Immunosuppressant and Anti-inflammatory agent. They have several adverse effects, majorly Insulin Resistance (IR) and Hypertension these are probably attributed to Oxidative Stress. In the present study, effect of SOD Mimetic Tempol (2,2,6,6,-tetramethyl-4-hydroxy-1-piperidinyloxy) was administered (1mmol/L) for Prophylactic as well as Therapeutic regimen in Experimental Induced Insulin Resistance in male Wister rats by using Dexamethasone (20μg/kg) subcutaneously and estimated Plasma Insulin and TBARS were measured in Plasma as well in isolated Aortic tissue as a marker of Oxidative Stress. HOMA-IR index and Mastuda Index were calculated as an Insulin Resistance/ Insulin Sensitivity. From the finding of present study, Tempol failed to produce any effect on IR so in conclusion, Oxidative Stress may be playing the Initiative role in Dexamethasone Induced IR.

Keywords


Insulin Resistance (IR), Oxidative Stress, Dexamethasone, Insulin Resistance Index (Homa- IR) And Insulin Sensitivity Index (Mastuda Index).

References