Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Antinephrotoxic Effect of Boerhaavia diffusa L. Root on Lead Acetate Induced Nephrotoxicity in Male Albino Rats


Affiliations
1 PG and Research Department of Biochemistry, Sengamala Thayaar Educational Trust Women's College, Sundarakkottai, Mannargudi-614016, Tamil Nadu, India
     

   Subscribe/Renew Journal


Many Nephroprotective herbal preparations have been recommended in Indian systems of medicine for the treatment of neprotic disorders. Protective action of Boerhaavia diffusa extract (BDE) was evaluated in the animal model of Nephrotoxicity induced by lead acetate. Kidney marker enzymes and antioxidant enzymes were changed in lead acetate intoxicated rats. Boerhaavia diffusa extract brought about a moderate changes in the activities of all the above said levels. The present observation suggested that the treatment with Boerhaavia diffusa extract enhance the recovery from lead acetate induced nephrotic damage due to its nephroprotective activity.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Adesina S K. Anticonvulsant properties of the ischolar_mains of Boerhaavia diffusa. Journal of Crude Drug Research. 17; 1979:84-86.

  • Alsaleh. The biochemical and clinical consequences of lead poisoning. Medicinal Research Reviews. 4;1994:415-486.

  • Bechara E J, Medeiros M H, Monteiro H P, Hermes-Lima M, Pereira B, Demasi M. A Free Radical Hypothesis Of Lead Poisoning And Inborn Porphyrias Associated With 5-Aminolevulinic Acid Overload. Quim Nova. 16;1993:385-392.

  • Bhalla T N, Gupta M P, Sheth P K and Bhargava K P. Anti-inflammatory activity of Boerhaavia diffusa. Indian Journal of Physiology and Pharmacology. 12; 1968:37.

  • Bonses R W, Taussky H H. J.Biol.Chem. 1945:158-581.

  • Brogan and Partners. Renal effect of Environmental and occupational lead exposure. Environmental. A Health. Perspectives. 105; 1997:928-938.

  • Chopra R N, Ghosh S, Dey P and Ghosh B N. Pharmacology and Therapeutics of Boerhaavia diffusa. Indian Medical Gazette. 68; 1923:203-208.

  • Feldman R G, White R F. Lead Neurotoxicity And Disorders Of Learning. J Child Neurol. 7;1992:354-359.

  • Fraga C G, Leibouitz B E and Toppel A C. Lipid peroxidation measured as TBARS in issue slices. Characterisation and comparision with homogenates and microsomes, Free radicals. Bio.med. 4;1988:155-161.

  • Gurer H, Ercal N. Can Antioxidants Be Beneficial In The Treatment Of Lead Poisoning? Free Radic Biol Med. 29;2000:927-945.

  • Halliwel B and Gutteridge M. Free radicals in biology and medicine, third edition Oxford University press.1999:930-36.

  • Halliwell B and Gutteridge J M. Free radicals in biology and medicine, oxford; oxford university press.1998.

  • Harvey C Gonick, Experimental model of lead Nephrotoxicity. Kidney. 41;1992:1192-1203.

  • Jain C K and Khanna N M. Punarnavosode:A new antifibrinolytic agent from Boerhaavia diffusa Linn. Indian Journal of Chemistry. 28;1989:163-166.

  • Jean harrj, Arrel, Toews, Matine, Krigmam and Pierre morel. The effect of lead toxicity. Toxicology and Applied Pharmacology. 3;1985:458-464.

  • Kakkar P, Das B, Viswanathan P N. A modified spectrophotometric assay of SOD. Ind.J.Biochem.Biophys.21;1984:130-132.

  • Koller L D. The Immunotoxic Effects Of Lead In Lead-Exposed Laboratory Animals. Ann N Y. Acad Sci. 587;1990:160-167.

  • Lowry. Methods in enzymology vol iii. J Biol Chem. 448;1951:193-265.

  • Mahajan M A, Acara M. Uptake and phosphorylation of thiamine in rat kidney cortical slices. I. Effect of ethanol. J Pharmacol Exp Ther. 268(3); 1994; 1311-1315.

  • Maria Valeria Auria, Valentina Sepe, Angela Zampella. Synthetic studies on homophymine A:stereoselective synthesis of (2R,3R,4R,6R)-3-hydroxy-2,4,6-trimethyloctanoic acid Tetrahedron. 65; 2009:3659-3663.

  • Mayne P D. The Kidneys And Renal Calculi. In:Clinical Chemistry In Diagnosis And Treatment. 6th Ed. London:Edward Arnold Publications.1994:2-24.

  • Mishra J P. Studies on the effect of indigenous drug Boerhaavia diffusa on kidney regeneration. Indian Journal of Pharmacy. 12;1980:59.

  • Nadkarni A K. Indian Meteria Medica. Vol.1.A.K.Nadkarani, Popular Prakashan Pvt.Ltd, Bombay, Maharashtra, India.1976:209-205.

  • Natelson S C. Microtech of Clin.Chem, For routine lab,C.C Thomas, Illiness.1957.

  • Ohata Y, Kongo-Nishimura M and Mastura T . Melatonin Prevents Disruption of Hepatic Reactive Oxygen Species Metabolism In Rats Treated With Carbon Tetrachloride. J. Pineal Res. 36; 2004:10-17.

  • Olukoya D K, Tdika N and Odugbumi T. Antibacterial activity of some medicinal plants from Nigeria. Journal of Ethnopharmacology.39;1993:69-72.

  • Rawat A K S, Mehrotra S, Tripathi S C, Shome U C. Hepatoproptective activity of Boerhaavia diffusa ischolar_main. Indian ethnomedicine, Pharmacology laboratory, National Botanical Research Institute, Lucknow.1996.

  • Rotruck J T, Pope A L, Ganther H E and Swason A B. Selenium; Biochemical role as a component of Glutathione peroxidase. Science. 179; 1973:588-590.

  • Shivashagari K S, Ravikumar V, Govindaraju P and Devaki. Effect of Boerhaavia diffusaon tissue antioxidant defense system during ethanol induced hepatotoxicity in rats. Journal of natural Remedies. 23; 2002.

  • Sies H. Oxidative stress:oxidants and antioxidants. Exp Physiol. 82; 1997:291-295.

  • Siliprandi and Noris. Use of L-carnitine in the treatment of toxic effects induced by the inhalation of halothane and other halogen-containing general anesthetics. Biochem.pharmcol. 35; 1988:3961-3964.

  • Sinha K A. Colorimetric assay of catalase. Ann Biochem. 47; 1972:389-394.

  • Sugawara E, Nakamura K, Miyake T, Fukumura A, Seki Y. Lipid Peroxidation and Concentration Of Glutathione In Erythrocytes From Workers Exposed To Lead. Br J Ind Med. 48; 1991:239-242.

  • Wang H P, Qian S Y, Schafer F Q, Domann F E, Oberley L W and Buettner G R. Phospholipid Hydroperoxide Glutathione Peroxidase Protects Against Singlet Oxygen-Induced Cell Damage Of Photodynamic Therapy. Free Radic Biol Med. 30; 2001:825-835.

  • Yokoyama K, Araki S, Muraka M, Morita Y, Katsuno N, Tanigawa T, Mori N. Subclinical vesticulo-cerebellar, arterier cerebellare lobe and spinocerebellar effects in lead workers in relation to current and past exposure. Neurotoxicity, 18; 1997:371-380.


Abstract Views: 353

PDF Views: 0




  • Antinephrotoxic Effect of Boerhaavia diffusa L. Root on Lead Acetate Induced Nephrotoxicity in Male Albino Rats

Abstract Views: 353  |  PDF Views: 0

Authors

N. Vaidegi
PG and Research Department of Biochemistry, Sengamala Thayaar Educational Trust Women's College, Sundarakkottai, Mannargudi-614016, Tamil Nadu, India
R. Anuradha
PG and Research Department of Biochemistry, Sengamala Thayaar Educational Trust Women's College, Sundarakkottai, Mannargudi-614016, Tamil Nadu, India

Abstract


Many Nephroprotective herbal preparations have been recommended in Indian systems of medicine for the treatment of neprotic disorders. Protective action of Boerhaavia diffusa extract (BDE) was evaluated in the animal model of Nephrotoxicity induced by lead acetate. Kidney marker enzymes and antioxidant enzymes were changed in lead acetate intoxicated rats. Boerhaavia diffusa extract brought about a moderate changes in the activities of all the above said levels. The present observation suggested that the treatment with Boerhaavia diffusa extract enhance the recovery from lead acetate induced nephrotic damage due to its nephroprotective activity.

References