A Study of Inducible Clindamycin Resistance in Staphylococci in a Tertiary Care Hospital in Western Uttar Pradesh

Aim: The aim of this study was to determine inducible clindamycin resistance in erythromycinresistant, clindamycin-sensitive staphylococcal strains isolated from clinical specimens. Material and Method: A total of 108 erythromycin-resistant, clindamycin-sensitive staphylococcal isolates from various clinical specimens were tested using D-test according to CLSI guidelines. Result: A total of 23 (21.3%) staphylococcal isolates were found to be D-test positive and demonstrated inducible clindamycin resistance (iMLSB phenotype). MRSA isolates showed highest percentage (25.8%) of inducible clindamycin resistant phenotypes. Conclusion: Inducible clindamycin resistance should be checked in staphylococcal isolates before administering clindamycin therapy in staphylococcal infections as it can lead to clinical failure.