International Journal of Contemporary Medicine

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A Study of Inducible Clindamycin Resistance in Staphylococci in a Tertiary Care Hospital in Western Uttar Pradesh


Affiliations
1 Department of Microbiology, Saraswathi Institute of Medical Sciences, Hapur, (UP), India
     

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Aim: The aim of this study was to determine inducible clindamycin resistance in erythromycinresistant, clindamycin-sensitive staphylococcal strains isolated from clinical specimens. Material and Method: A total of 108 erythromycin-resistant, clindamycin-sensitive staphylococcal isolates from various clinical specimens were tested using D-test according to CLSI guidelines. Result: A total of 23 (21.3%) staphylococcal isolates were found to be D-test positive and demonstrated inducible clindamycin resistance (iMLSB phenotype). MRSA isolates showed highest percentage (25.8%) of inducible clindamycin resistant phenotypes. Conclusion: Inducible clindamycin resistance should be checked in staphylococcal isolates before administering clindamycin therapy in staphylococcal infections as it can lead to clinical failure.

Keywords

D-test, MRSA, iMLSB Phenotype , Clindamycin, erm Methylase.
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  • A Study of Inducible Clindamycin Resistance in Staphylococci in a Tertiary Care Hospital in Western Uttar Pradesh

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Authors

Sanjeev Dimri
Department of Microbiology, Saraswathi Institute of Medical Sciences, Hapur, (UP), India
Shweta Rastogi
Department of Microbiology, Saraswathi Institute of Medical Sciences, Hapur, (UP), India
S. P. Garg
Department of Microbiology, Saraswathi Institute of Medical Sciences, Hapur, (UP), India

Abstract


Aim: The aim of this study was to determine inducible clindamycin resistance in erythromycinresistant, clindamycin-sensitive staphylococcal strains isolated from clinical specimens. Material and Method: A total of 108 erythromycin-resistant, clindamycin-sensitive staphylococcal isolates from various clinical specimens were tested using D-test according to CLSI guidelines. Result: A total of 23 (21.3%) staphylococcal isolates were found to be D-test positive and demonstrated inducible clindamycin resistance (iMLSB phenotype). MRSA isolates showed highest percentage (25.8%) of inducible clindamycin resistant phenotypes. Conclusion: Inducible clindamycin resistance should be checked in staphylococcal isolates before administering clindamycin therapy in staphylococcal infections as it can lead to clinical failure.

Keywords


D-test, MRSA, iMLSB Phenotype , Clindamycin, erm Methylase.

References