International Journal of Contemporary Medicine

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Micro-albuminuria & CRP-Early Mortality Marker in ACS


Affiliations
1 Dept. of Medicine, School of Medical Science, G. Noida, U.P, India
     

   Subscribe/Renew Journal


This study was performed in 60 Acute MI patient, Non-diabetic, admited within 24 hr of chest pain, to investigate the prevalence & significance of Micro Albuminuria (MAU) & CRP as a predictor of inhospital mortality & to correlate it with other prognostic markers. Serial spot urinary Alb/Crt Ratio (ACR) measured from Day 1 to Day 7 along with hemodynamic measurement clinically by Killip'S class & EF by ECHO. Total 7 days mortality was recorded. Microalbumin (>30μg/mg) was found in 95% of patient on day 1. Groups with higher MAU (>100μg/mg) on day 1 was associated with high mortality(p<0.01). Increasing or static MAU had a positive correlation with deteriorating Killip'S class along with direct correlation with decrease in LVEF serially from Day 1 to Day 7. Thus MAU was found to be a reliable predictor of short term in-hospital mortality in ACS patient.

Keywords

MAU, CRP, Acute Myocardial Infarction.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Berton G, Cordiano R, Palmieri R,Cucchini F,De Toni R,Palatini P – Microalbuminuria during AMI,a strong predictor for 1 year mortality.Eur Heart J 2001:22:1466-75

  • Antman EM, Hand M,Armstrong PW,et al 2007 focused update of the ACC/AHA 2004 guideline for the management of patient with AMI,reports on practice guideline.Am coll cardiol 2008;51; 210-247.

  • Gerstein HC,Mann JF,YiQ,Zinman B,Dinneen SF,Hoogwerf B,et al- Albuminuria & risk of cardiovascular events,death & heart failure in diabetic & non-diabetic patient.JAMA 2001;286:421-6.

  • Jensen JS- MAU & risk of atherosclerosis: clinical, epidemiological & physiological investigations. Dan Med Bull 2000: 47:63-78.

  • Killip T III, Kimball JT- Treatment of MI in coronary care unit,a 2 year experience with 250 patients. Am J cardiol 1967:20:457-64.

  • Morrison LJ, Verbeek PR,McDonald AC,et al.Mortality & in-hospital mortality for AMI.A meta-analysis.JAMA 2000:283:2686-2692.

  • Antman EM,Anbe DT,Armstrong PW,Bates ER,Green LA,Hard M,et al- ACC/AHA guideline for the management of patients with ST elevation MI. J Am Coll Cardiol 2004:44:E1-E211.

  • Koulouris S Lekatsas I,Karabinos I,Loannidis G,Katostaras T,Kranidis A,et al – MAU-a strong predictor of 3 years adverse prognosis in nondiabetic patients with AMI.Am Heart J 2005:149:840-5.

  • Obeidat O,Alam M,Divine GW,Khaja F,Goldstein S,Sabbah H- Echocardiographic predictor of prognosis after 1st AMI. Am J Cardiol 2004:94: 1278-1280.

  • Berton G,Citro T,Palmieri R,Petucco S,De Tori R,Palatini P- Alb.excretion rate increases during AMI & strongly predict early mortality. Circulation 1997:96:3338-45


Abstract Views: 394

PDF Views: 0




  • Micro-albuminuria & CRP-Early Mortality Marker in ACS

Abstract Views: 394  |  PDF Views: 0

Authors

Ravish Kr Verma
Dept. of Medicine, School of Medical Science, G. Noida, U.P, India
G D Sharma
Dept. of Medicine, School of Medical Science, G. Noida, U.P, India

Abstract


This study was performed in 60 Acute MI patient, Non-diabetic, admited within 24 hr of chest pain, to investigate the prevalence & significance of Micro Albuminuria (MAU) & CRP as a predictor of inhospital mortality & to correlate it with other prognostic markers. Serial spot urinary Alb/Crt Ratio (ACR) measured from Day 1 to Day 7 along with hemodynamic measurement clinically by Killip'S class & EF by ECHO. Total 7 days mortality was recorded. Microalbumin (>30μg/mg) was found in 95% of patient on day 1. Groups with higher MAU (>100μg/mg) on day 1 was associated with high mortality(p<0.01). Increasing or static MAU had a positive correlation with deteriorating Killip'S class along with direct correlation with decrease in LVEF serially from Day 1 to Day 7. Thus MAU was found to be a reliable predictor of short term in-hospital mortality in ACS patient.

Keywords


MAU, CRP, Acute Myocardial Infarction.

References