Open Access
Subscription Access
Formulation and in-vitro Drug Release for β-cyclodextrin Nanosphears using Emulsification Solvent-evaporation Method
This study gives information about the formulation of β-cylcodextrin nanosphere by emulsification solvent-evaporation method based on emulsifying an organic phase containing the β-cylcodextrin in an aqueous phase of pluronic-F68 as surfactant. The nanospheres are loaded with hydrophobic drug and the in-vitro drug release study was conducted. The formulation of colloidal particle was associated with amphiphilic properties of the β-cylcodextrin derivatives. However, the partitioning of the β- cyclodextrin between the organic and aqueous phases is always depends on the concentration of the surfactant. In the case of nanospheres loaded with Irinotican hydrochloride, the partitioning of the drug occurs between the dispersed phase containing β- cylcodextrin and the continuous aqueous phase containing pluronic-F68.
Keywords
Amphiphilic Cyclodextrins, Emulsification, Solvent-evaporation Method, Nanospheres, Irinotecan, Surfactant, Pluronic-F68
User
Information
- Allemann E, Gurny R and Doelker E (1992) Preparation of aqueous polymeric nanodispersions by a reversible salting out process: influence of process parameters on particle size. Int. J.Pharm., 87, 247-253.
- Allemann E, Leroux JC, Gurny R and Doelker E (1993) In vitro extended-release properties of drug-loaded poly(DL-Lactide Acid) nanospheress produced by saltingout procedure. Pharm. Res., 10, 1732-1737.
- Al-Saden AA, Whateley TL and Florence AT (1982) Polaxamer Association in aqueous solution. J.Colloid Interface Sci., 90, 303-309.
- Bodmeier R and Chen H 1990 Indomethacin polymeric nanosupensions prepared by microfluidization. J. Controlled Release, 12, 223-233.
- Bodmeier R and McGinity JW (1987a) Polyactide acid mircospheres containing quinidine base and quinidine sulphate prepared by slovent evaporation techniquie. I.Method and morphology. J.Microencapsulation, 4, 279- 288.
- Bodmeier R and McGinity JW (1987b) Polylactide acid microspheres containing quinidine base and quinidine sulphate prepared by slovent evaporation techniquie. II. Some processes parameters influencing the preparation and properties of microspheres. J.Microencapsulation, 4, 289-297.
- Fessi H, Puisieux F and Devissaguet JP (1988) Procede de preparation de systems colloidaux dispersibles d’une substance sous forme de nanospheres. US Patent no.5118, 528.
- Jeffery H, Davis SS and O’Hagan (1991) The preparation and characterisation of poly(lactide-co-glycolide) microparticles. I: Oil-in-water emulsion solvent evaporation. Int. J.Pharm., 77, 169-175.
- Kataoka K, Kwon G, Yokoyama M, Okano T, Sakurai Y (1993) Block copolymer micelles as vehicles for drug delivery. J.Controlled Release, 24, 119-132.
- Lemo-senna E, Wouessidejewe D, Lesieur S, Puisieux F, Couarraze G and Duchene D (1998) Evaluation of the hydrophobic drug loading characteristics in nanopreciptated amphiphilic cyclodextrins nanosphere. Pharm. Develop Tech, 3, 85-94.
Abstract Views: 402
PDF Views: 82