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Hepatocellular Enzyme Activities and Protein Level Following Administration of Vitamins during Chloroquine Induced Hepatoxicity in Wistar Rats


Affiliations
1 Dept of medical laboratory science, faculty of health science, Imo State University, owerri, Imo State, Nigeria
2 Department of Biochemistry, Federal University of Technology, Owerri, Imo State, Nigeria
3 ThankGod Medical Laboratories, Ihiala Anambra State, Nigeria
 

Objective The effect of vitamins against chloroquine induced hepatoxicity was studied in wistar rats. Analysis of serum AST, ALT and ALP activities with those of total protein and albumin were carried out. Method: Single oral administration of chloroquine (970mg/kg body weight) caused significant increase in AST, ALT and ALP while protein and albumin concentration were reduced. However, simultaneous treatment of chloroquine with 200mg/kg body weight and 4.3 mg/kg of vitamin C and E respectively were administered for 14days. Results: The levels serum AST, ALT and ALP were significantly decreased following the treatment with vitamin C and E. Conclusion: These observations suggest that administration of high dose of chloroquine can cause increase in serum hepatocellular enzymes activities, which is suggestive of liver necrosis which can be ameliorated to varying degrees by vitamins C and E. Hence, fruits rich in vitamin C and E are highly recommended in liver disorders.

Keywords

Hepato-cellular Enzymes, Protein, Chloroquine, Hepatoxicity
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  • Hepatocellular Enzyme Activities and Protein Level Following Administration of Vitamins during Chloroquine Induced Hepatoxicity in Wistar Rats

Abstract Views: 368  |  PDF Views: 68

Authors

Nnodim Johnkennedy
Dept of medical laboratory science, faculty of health science, Imo State University, owerri, Imo State, Nigeria
Ujowundu Cosmus Onyekachi
Department of Biochemistry, Federal University of Technology, Owerri, Imo State, Nigeria
Udujih Hellen Ifeoma
Dept of medical laboratory science, faculty of health science, Imo State University, owerri, Imo State, Nigeria
Okorie Hope
Dept of medical laboratory science, faculty of health science, Imo State University, owerri, Imo State, Nigeria
Nwobodo Emmanuel Ikechukwu
ThankGod Medical Laboratories, Ihiala Anambra State, Nigeria
Nwadike Constance Nnedimma
Dept of medical laboratory science, faculty of health science, Imo State University, owerri, Imo State, Nigeria

Abstract


Objective The effect of vitamins against chloroquine induced hepatoxicity was studied in wistar rats. Analysis of serum AST, ALT and ALP activities with those of total protein and albumin were carried out. Method: Single oral administration of chloroquine (970mg/kg body weight) caused significant increase in AST, ALT and ALP while protein and albumin concentration were reduced. However, simultaneous treatment of chloroquine with 200mg/kg body weight and 4.3 mg/kg of vitamin C and E respectively were administered for 14days. Results: The levels serum AST, ALT and ALP were significantly decreased following the treatment with vitamin C and E. Conclusion: These observations suggest that administration of high dose of chloroquine can cause increase in serum hepatocellular enzymes activities, which is suggestive of liver necrosis which can be ameliorated to varying degrees by vitamins C and E. Hence, fruits rich in vitamin C and E are highly recommended in liver disorders.

Keywords


Hepato-cellular Enzymes, Protein, Chloroquine, Hepatoxicity

References