Indian Journal of Public Health Research & Development

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Correlation of Interleukin-6 with Serum Estradiol Mean Levels in Menopause Women at Rsup H Adam Malik Medan


Affiliations
1 Department of Obstetric and Gynecology, Medicine Faculty, Universitas Sumatera Utara, Indonesia
2 Professor of Fertility Endocrine Reproduction, Department of Obstetrics and Gynecology, Medical Faculty of Universitas Sumatera Utara/President of Indonesian Menopause Association (Perkumpulan Menopause Indonesia), Indonesia
3 Staff of Social Obstetric Division, Department of Obstetrics and Gynecology, Medical Faculty of Universitas Sumatera Utara, Indonesia
4 Professor of Feto Maternal Division, Department of Obstetrics and Gynecology, Medical Faculty of Universitas Sumatera Utara, Indonesia
5 Staff of Oncology Gynecology Division, Department of Obstetrics and Gynecology, Medical Faculty of Universitas Sumatera Utara, Indonesia
     

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Aim: To determine the correlation of Interleukin-6 (IL-6) with serum estradiol levels in menopausal women.

Method: This research is a case series research in postmenopausal women to assess the correlation between Interleukin-6 (IL-6) and serum estradiol levels that performed at H Adam Malik General Hospital Medan, starting in August 2017 until 38 samples which met the inclusion and exclusion criteria were fulfill,using non probability sampling technique with consecutive sampling. Serum estradiol and IL-6 levels was examined, then sent to the clinical laboratory. Data tabulated to be analyzed statistically.

Results: The mean serum estradiol level in menopausal women is 29.74 ± 18.69. The mean IL-6 level was 85.03 ± 33.66, in this research showed that in menopausal women there was an increase in IL-6 levels. By using the Spearman Test, the results showed that there was a significant correlation between estradiol and IL-6 with p value <0.004.

Conclusion: There is a significant negative correlation between serum estradiol and IL-6 levels, which means that there is an inverse relationship between serum estradiol and IL-6 levels with weak negative strength, where decreasing estradiol does not always increase IL-6 levels.


Keywords

Estradiol, Interleukin-6, IL-6, Menopause, Inflammation.
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  • Correlation of Interleukin-6 with Serum Estradiol Mean Levels in Menopause Women at Rsup H Adam Malik Medan

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Authors

Nutrisia Latjindung
Department of Obstetric and Gynecology, Medicine Faculty, Universitas Sumatera Utara, Indonesia
M. Fidel Ganis Siregar
Professor of Fertility Endocrine Reproduction, Department of Obstetrics and Gynecology, Medical Faculty of Universitas Sumatera Utara/President of Indonesian Menopause Association (Perkumpulan Menopause Indonesia), Indonesia
Hanudse Hartono
Staff of Social Obstetric Division, Department of Obstetrics and Gynecology, Medical Faculty of Universitas Sumatera Utara, Indonesia
Sarma N. Lumbanraja
Professor of Feto Maternal Division, Department of Obstetrics and Gynecology, Medical Faculty of Universitas Sumatera Utara, Indonesia
Deri Edianto
Staff of Oncology Gynecology Division, Department of Obstetrics and Gynecology, Medical Faculty of Universitas Sumatera Utara, Indonesia
Iman Helmi Effendi
Staff of Social Obstetric Division, Department of Obstetrics and Gynecology, Medical Faculty of Universitas Sumatera Utara, Indonesia

Abstract


Aim: To determine the correlation of Interleukin-6 (IL-6) with serum estradiol levels in menopausal women.

Method: This research is a case series research in postmenopausal women to assess the correlation between Interleukin-6 (IL-6) and serum estradiol levels that performed at H Adam Malik General Hospital Medan, starting in August 2017 until 38 samples which met the inclusion and exclusion criteria were fulfill,using non probability sampling technique with consecutive sampling. Serum estradiol and IL-6 levels was examined, then sent to the clinical laboratory. Data tabulated to be analyzed statistically.

Results: The mean serum estradiol level in menopausal women is 29.74 ± 18.69. The mean IL-6 level was 85.03 ± 33.66, in this research showed that in menopausal women there was an increase in IL-6 levels. By using the Spearman Test, the results showed that there was a significant correlation between estradiol and IL-6 with p value <0.004.

Conclusion: There is a significant negative correlation between serum estradiol and IL-6 levels, which means that there is an inverse relationship between serum estradiol and IL-6 levels with weak negative strength, where decreasing estradiol does not always increase IL-6 levels.


Keywords


Estradiol, Interleukin-6, IL-6, Menopause, Inflammation.



DOI: https://doi.org/10.37506/v11%2Fi1%2F2020%2Fijphrd%2F194029