Indian Journal of Public Health Research & Development

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Study of Biochemical Changes in Occupational Exposure of Portland Cement among Construction Workers in Ujjain, Madhya Pradesh


Affiliations
1 Department of Biochemistry, Saraswathi Institute of Medical Sciences Pilkhuwa, Hapur, Dist Gaziabad (UP), India
2 Dept of Biochemistry, SBH Govt. Medical College, Dhule (Maharashtra), India
3 Dept of Biochemistry, L T M Medical College & Hospital, Sion, Mumbai (Maharashtra), India
     

   Subscribe/Renew Journal


Cement used in building and various construction works is a complex mixture of several metal oxides, silicates and miscellaneous compounds. In India, laborers involved in construction work are constantly exposed to the cement various ways. Biochemical effects of the occupational exposure in 31 workers were assessed by Aspartate transaminase, Alanine transaminase, Calcium, Magnesium, Maolondialdehyde and Ascorbate levels in serum. It was found that serum ALT, AST and calcium levels were elevated as compared to the controls. The Dirties ratio was significantly higher in the workers. The lipid peroxidation index was higher while ascorbate level was significantly lower in the cases. It is concluded that the construction worker show marginal alteration in liver functions which is secondary to oxidative stress generated by complex interaction of toxic cement compounds.

Keywords

Cement, Alanine Transaminase, Aspartate Transaminase, Calcium Magnesium, Maolondialdehyde, Ascorbic Acid
Subscription Login to verify subscription
User
Notifications
Font Size


  • Singh VS and Pandey DN. Human Health Risk due to Cement Dust Exposure. Climate Change and CDM Cell. Rajasthan State Pollution Control Board. RSPCB Policy Brief No. 2/2011 © 2011, RSPCB

  • Oliver LC, Miracle MC, Mahill H, Littman AB, Okares JRR. Respiratory symptoms and lung functions in workers in heavy and highway construction: A cross sectional study. Am J Ind Med 2001; 40: 73-86.

  • Meo DA, Rashid S, Khan MM, Shujauddin S, Tuwaidri A. Effect of cement dust exposure on phagocytic function of polymorphonuclear neutrophils in cement mill workers. Int J Occ Med Environ Health 2008; 21(2): 133-139.

  • Ogunbileje JO, Akinosun OM, Anetor JI, Akinduti PA, Ejilude O, Nwobi NL and Akinbo JA. Effects of different cement factory sections products on immunoglobulins levels and some biochemical parameters in Nigerian cement factory workers. NY Sci J 2010; 3(12): 102-106.

  • Rosalkii SB. Enzyme profiles as indicator of susceptibility to environmental toxic agent. Proc Roy Soc Med 1974; 67: 633-636.

  • Nyberg P, Klockars M. Measurement of reactive oxygen metabolites produced by human monocyte derived macrophages exposed to mineral dust. Int J Exp Pathol 1990; 71: 537-544.

  • Aydin S, Aydin S, Croteau G. Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers. J Med Biochem 2010; 29(2): 78-83.

  • Ali MA. Alteration of some biophysical properties of erythrocytes of silicotic patients. Romanian J Biophys 2007; 17(4): 225–236.

  • Ezeonu FC, Ezejiofor TIN. Biochemical indicators of occupational health hazards in Nkalagu cement industry workers Nigeria. The science of the total environment 1999; 278: 275-278.

  • Fatima SK, Ramana Devi CV, Prabhavathi PA. Reddy PP. Blood serum protein and calcium levels in Portland cement factory workers. Ind J Environ Toxicol 1997; 7(2): 56-57.

  • Reitman S & Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Amer. J. Clin. Pathol. 1957; 28: 56-63.

  • Kyaw, A. A simple colorimetric method for ascorbic acid determination in blood plasma. Clin Chim Acta 1978; 86 (2): 153-157.

  • Weisman N & Pileggi VJ. Inorganic ions. In, Clinical Chemistry : Principles and Techniques. Henry PJ, Cannon DC & Winkelman W, eds, 1974, Harper & Row publishers, Maryland, USA, p639-754.

  • Devsagayam TPA, Boloor KK, Ramsarma. Methods for estimating lipid peroxidation. Ind J Biochem Biophy 2003; 40: 300-308.

  • Orman A, Kahraman A, Cakar H, Ellidokuz H, Serteser M. Plasma malondialdehyde and erythrocyte glutathione levels in workers with cement dust exposure silicosis. Toxicology 2005; 27(1): 15-20.

  • Aydin S, Aral I, Kilic N, Bakan I, Aydin S, Erman F. The level of antioxidant enzymes, plasma vitamins C and E in cement plant workers. Clin Chim Acta 2004; 341(1-2); 193-198.

  • Chatterjee IB, Anuradha N. Ascorbic acid: A scavenger of oxy-radical. Biochem Biophys 1991; 28: 233-236.

  • Pournourmohammadi S, Khazaeli P, Tajvar A, Eslamizad S, Attaallah Naemi A, Abdollahi M. Cement plant workers have less total antioxidant capacity and thiol molecules in plasma. Toxicol Lett 2008; 180(1): S148.


Abstract Views: 362

PDF Views: 0




  • A Study of Biochemical Changes in Occupational Exposure of Portland Cement among Construction Workers in Ujjain, Madhya Pradesh

Abstract Views: 362  |  PDF Views: 0

Authors

A Y Mane
Department of Biochemistry, Saraswathi Institute of Medical Sciences Pilkhuwa, Hapur, Dist Gaziabad (UP), India
V R Bhagwat
Dept of Biochemistry, SBH Govt. Medical College, Dhule (Maharashtra), India
S D Mane
Dept of Biochemistry, L T M Medical College & Hospital, Sion, Mumbai (Maharashtra), India

Abstract


Cement used in building and various construction works is a complex mixture of several metal oxides, silicates and miscellaneous compounds. In India, laborers involved in construction work are constantly exposed to the cement various ways. Biochemical effects of the occupational exposure in 31 workers were assessed by Aspartate transaminase, Alanine transaminase, Calcium, Magnesium, Maolondialdehyde and Ascorbate levels in serum. It was found that serum ALT, AST and calcium levels were elevated as compared to the controls. The Dirties ratio was significantly higher in the workers. The lipid peroxidation index was higher while ascorbate level was significantly lower in the cases. It is concluded that the construction worker show marginal alteration in liver functions which is secondary to oxidative stress generated by complex interaction of toxic cement compounds.

Keywords


Cement, Alanine Transaminase, Aspartate Transaminase, Calcium Magnesium, Maolondialdehyde, Ascorbic Acid

References