Indian Journal of Public Health Research & Development

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

BIND Syndrome - a Life Threatening Sequel to Kernicterus


Affiliations
1 Department of Oral Medicine and Radiology, Bapuji Dental College and Hospital, Davangere, Karnataka, India
     

   Subscribe/Renew Journal


Bilirubin Induced Neurological Dysfunction Syndrome (BIND) Syndrome is a condition caused by bilirubin toxicity to the basal ganglia, hippocampus and various brainstem nuclei. In the acute phase, severely jaundiced infants become lethargic, hypotonic and suck poorly. If the hyperbilirubinemia is not treated, the infant becomes hypertonic and may develop a fever and a high-pitched cry.[1] The hypertonia is manifested by backward arching of the neck (retrocollis) and trunk (opisthotonus). Surviving infants usually develop a severe form of choreoathetoid cerebral palsy, hearing loss, dental dysplasia, paralysis of upward gaze and, less often, intellectual and other handicaps.[2] Hereby presenting a rare case report of a 9 year old female patient having BIND Syndrome with typical dental manifestations.

Keywords

BIND Syndrome, Kernicterus, Hyperbilirubinemia, Dental Dysplasia, Cerebral Palsy
Subscription Login to verify subscription
User
Notifications
Font Size


  • Van PR. Diagnosis of kernicterus in the neonatal period. Pediatrics 1969; 28: 870-874.

  • Volpe JJ. Bilirubin and brain injury: Neurology of the Newborn, 4th edition Philadelphia: WB Saunders; 2001. 490-514.

  • American Academy of Pediatrics Practice Parameter. Management of hyperbilirubinemia in the healthy term newborns. Pediatrics 1994; 94: 558-565.

  • Johnson L, Brown AK, Bhutani VK. BIND: A clinical score for bilirubin induced neurologic dysfunction in newborns. Pediatr Suppl 1999; 104: 746-749.

  • Washington EC, Ector W, Abboud M, Ohning B, Holding KR. Hemolytic jaundice due to G6PD deficiency causing kernicterus in a newborn female. South Med J. 1995; 88: 776-779

  • Shapiro SM. Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND). J Perinatol. Jan 2005; 25(1): 54-59.

  • Johnson LH, Brown AK, Bhutani VK. Systembased approach to management of neonatal jaundice and prevention of kernicterus. J Pediatr 2002; 140: 396-403.

  • Maisels MJ, Newman TB. Bilirubin and neurologic dysfunction: Do we need to change what we are doing? Pediatr Res 2001; 50: 677-679.

  • AAP Subcommittee on Neonatal Hyperbilirubinemia. Neonatal jaundice and kernicterus. Pediatrics 2001; 108: 763-765.


Abstract Views: 419

PDF Views: 0




  • BIND Syndrome - a Life Threatening Sequel to Kernicterus

Abstract Views: 419  |  PDF Views: 0

Authors

Sachin Mittal
Department of Oral Medicine and Radiology, Bapuji Dental College and Hospital, Davangere, Karnataka, India
V. G. Pramod
Department of Oral Medicine and Radiology, Bapuji Dental College and Hospital, Davangere, Karnataka, India
L. Ashok
Department of Oral Medicine and Radiology, Bapuji Dental College and Hospital, Davangere, Karnataka, India

Abstract


Bilirubin Induced Neurological Dysfunction Syndrome (BIND) Syndrome is a condition caused by bilirubin toxicity to the basal ganglia, hippocampus and various brainstem nuclei. In the acute phase, severely jaundiced infants become lethargic, hypotonic and suck poorly. If the hyperbilirubinemia is not treated, the infant becomes hypertonic and may develop a fever and a high-pitched cry.[1] The hypertonia is manifested by backward arching of the neck (retrocollis) and trunk (opisthotonus). Surviving infants usually develop a severe form of choreoathetoid cerebral palsy, hearing loss, dental dysplasia, paralysis of upward gaze and, less often, intellectual and other handicaps.[2] Hereby presenting a rare case report of a 9 year old female patient having BIND Syndrome with typical dental manifestations.

Keywords


BIND Syndrome, Kernicterus, Hyperbilirubinemia, Dental Dysplasia, Cerebral Palsy

References