Open Access
Subscription Access
Open Access
Subscription Access
Effect of Alcoholic Extract of Withania somnifera Linn Roots on Reproductive Organs in Streptozotocin Induced Diabetic Rats
Subscribe/Renew Journal
"Effect of alcoholic extract of Withania somnifera linn ischolar_mains on reproductive organs in streptozotocin induced diabetic rats." Withania somnifera linn(WS) is a perennial herb used in various Ayurvedic treatment procedures. Its role over the reproductive system is less studied especially in the diabetic.
Aim
1.To rule out the effect of WS alcoholic ischolar_main extract over the weight of the reproductive organs of Streptozotocin induced diabetic male rats.
2.To rule out the plants ability to increase the sperm count.
Material and methods
Twenty four adult male albino rats were grouped into four groups. Diabetes induced by injecting a single dose of Streptozotocin (50mg/kg BW) intraperitoneally. Insulin was given to one group with 5 units/Kg BW intraperitoneally for 30 days. Alcoholic ischolar_main extract of WS (500mg/Kg) was given to another diabetic group orally for 30days. Blood sugar, Body weight, Weight of Testes, Cauda epididymis and Caudal Sperm count was determined on 31st day. Data collected were statistically analysed using SPSS ver. 15.0 software.
Results
Statistically significant improvement in terms of testes weight and Caudal sperm count was obtained in W. somnifera treated diabetic rats than that of insulin treated.
Conclusion
Withania somnifera ischolar_main extracts had the potency to increase the reproductive efficiency of the diabetic rats.
Keywords
- Akhtar FM, Ali MR. Study of antidiabetic effect of a compound medicinal plant prescription in normal and diabetic rabbits. Journal of Pakistan Medical Association 1984; 34: 239 -244.
- Brinker,F. Herb contraindications and drug interactions,2nd Ed; Eclectic medical Publications Sandy,Or,USA ,1998 ;pp.36-82.
- Rajangam Udayakumar, Sampath kasturirengan et al, Hypoglycemic and Hypolipidemic effects of Withania somnifera ischolar_main and leaf extracts on Alloxan induced diabetic rats, International journal of molecular sciences, 2009,10,2367 – 2382.
- Malik F, Kumar A, Bhushan S, et al, Immune modulation and apoptosis induction: Two sides of antitumoural activity of a standardised herbal formulation of Withania somnifera. European Journal of Cancer 2009, March (5).
- Kulkarni S K, Ashish Dhir, Withania Somnifera- an Indian Ginseng, Progress in Neuro-psycho Pharmacology & Biological psychiatry,2008 (32)1093 -1105.
- Singh N, Singh SP, Nath R et al.Prevention Urethane induced lung adenomas by Withania somnifers dunal in albino mice.International journal of crude drug research 1986;24: 90-100.
- Devi PU,Sharada AC,Solomon FE, Kamath MS.Invivo growth inhibitory effect of Withania somnifera on a transplantable mouse tumor,Sarcoma 180.Indian Journal of Experimental Biology 1992 ;30: 169-172.
- Devi P U, Sharada A C, Solomon F E. Anti-tumor and radiosensitising effects of Withania somnifera (Ashwagandha) on transplantable mouse tumor sarcoma 180. Indian J. Exp. Biol. 1993, 31, 607-611.
- Sharad AC, Solomon FE, et al . Antitumor and radiosensitising effects of Withania A on mouse Ehrlich ascites carcinoma in vivo . Acta Oncol 1996; 35 : 95 - 100.
- Chatterjee A, Pakrashi SC, The Treatise on Indian Medicinal plants 1995;4;208 -212.
- Devi Pu,Sharada AC,Solomon FE.In vivo growth inhibitory and radiosensitizing effects of Withania Somnifera on mouse Ehrlich ascities carcinoma.Cancer Lett 1995; 95:189-193.
- Dadkar VN, Ranadive NU, Dhar HL, Evaluation of anti- stress activity of Withania somnifera, Indian journal of clinical Biochemistry 1987,2; 101 -108.
- Ahmad MK, Mahdi AA, Shukla KK et al Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males . Fertil Steril- 2009 Jun 5. [Epub ahead of print]
- Seethalakshmi L, Menon M, Diamond D. The effect of streptozotocin-induced diabetes on the neuroendocrine-male reproductive tract axis of the adult rat. J Urol- 1987 Jul;138(1):190-4.
- Singh N, Nath R, Lata A et al Withania somnifera, a rejuvenating herbal drug which enhances survival during stress. International journal of Crude drug research, 1982; 20; 29-35.
Abstract Views: 353
PDF Views: 0