Indian Journal of Public Health Research & Development

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Acute Neurotoxicity with Appropriate Dose of Isoniazid: a Case Report


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1 Rajiv Gandhi Institute of Medical Sciences Adilabad 504001, A.P, India
     

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Isoniazid (INH) is most frequently used in combination with other drugs for the treatment of tuberculosis or as monotherapy for treatment of latent tuberculous infection. Seizures due to anti-tubercular chemotherapy are a rare side effect. INH causing status epilepticus has been very rarely reported to cause seizures. We present a patient who, after 5 months of treatment with appropriate dose of INH, evolved to status epilepticus. Seizures could be controlled only after administering of pyridoxine.

Keywords

Isoniazid, Acute Neurotoxicity, Status Epilepticus, Seizures, Pyridoxine
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  • Acute Neurotoxicity with Appropriate Dose of Isoniazid: a Case Report

Abstract Views: 275  |  PDF Views: 0

Authors

N. M. Aleemuddin
Rajiv Gandhi Institute of Medical Sciences Adilabad 504001, A.P, India

Abstract


Isoniazid (INH) is most frequently used in combination with other drugs for the treatment of tuberculosis or as monotherapy for treatment of latent tuberculous infection. Seizures due to anti-tubercular chemotherapy are a rare side effect. INH causing status epilepticus has been very rarely reported to cause seizures. We present a patient who, after 5 months of treatment with appropriate dose of INH, evolved to status epilepticus. Seizures could be controlled only after administering of pyridoxine.

Keywords


Isoniazid, Acute Neurotoxicity, Status Epilepticus, Seizures, Pyridoxine

References