Indian Journal of Public Health Research & Development

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Acute Neurotoxicity with Appropriate Dose of Isoniazid: a Case Report


Affiliations
1 Rajiv Gandhi Institute of Medical Sciences Adilabad 504001, A.P, India
     

   Subscribe/Renew Journal


Isoniazid (INH) is most frequently used in combination with other drugs for the treatment of tuberculosis or as monotherapy for treatment of latent tuberculous infection. Seizures due to anti-tubercular chemotherapy are a rare side effect. INH causing status epilepticus has been very rarely reported to cause seizures. We present a patient who, after 5 months of treatment with appropriate dose of INH, evolved to status epilepticus. Seizures could be controlled only after administering of pyridoxine.

Keywords

Isoniazid, Acute Neurotoxicity, Status Epilepticus, Seizures, Pyridoxine
Subscription Login to verify subscription
User
Notifications
Font Size


  • Temmerman, W, Dhondt A, Vandewoude K. Acute isoniazid intoxication: seizures, acidosis and coma. Acta Clin Belg. 1999; 54: 211–216

  • Asnis DS, Bhat JG, Melchert AF. Isoniazid overdose: four case reports and review of the literature.Ann. Pharmacother. 1993; 27:444–446

  • Thundiyil JG, Kearney TE, Olson KR. Evolving epidemiology of drug-induced seizures reported to a Poison Control Center System. J Med Toxicol. 2007;3(1):15-9.

  • Bloch AB, Rieder HL, Kelly GD, Cauthen GM, Hayden CH, Snider DE. The epidemiology of TB in the U.S.: implications for diagnosis and treatment. Clin Chest Med. 1989;10:297-313.

  • Alvarez FG, Guntupalli KK. Isoniazid overdose: four case reports and review of the literature. Intensive Care Med. 1995;2:641-4.

  • Girling DJ. Adverse effects of anti-tuberculousis drugs. Drugs. 1982;23:56-74

  • Romero JA, Kuczler FJ. Isoniazid overdose: recognition and management. Am Fam Physician. 1998;57(4):749- 52.

  • Wallace, K. L. Antibiotic-induced convulsions.Crit. Care Clin. 1997;13:741–762

  • Williams, H. L. and Bain, J. A.: Convulsive effect of hydrazines: relationship to pyridoxine. Int. Rev. Neurobiol. 1961;3: 319–348

  • Wason S, Lacouture P. G, and Lovejoy F. H. Single highdose pyridoxine treatment for isoniazid overdose. JAMA. 1981;246:1102–1104

  • Minns, Alicia B, Ghafouri, Nazli , Clark, Richard F. Isoniazid-Induced Status Epilepticus in a Pediatric Patient After Inadequate Pyridoxine Therapy. Pediatric Emergency Care. 2010; 26:380-81

  • Lheureux, Philippe; Penaloza, Andrea; Gris, Mireille. Pyridoxine in clinical toxicology: a review. European Journal of Emergency Medicine. 2005;12(2):78-85

  • Katz BE, Carver MW. Acute poisoning with isoniazid treated by exchange transfusion. Pediatrics. 1956;18:72-6.

  • Cocco AE, Pazouek LJ. Acute isoniazid intoxication management by peritoneal dialysis. N Engl J Med. 1963;269:852-3.

  • Konigshausen TH, Altrogge G, Hein D, Grapensee B, Potter J. Hemodialysis and hemoperfusion in treatment of most severe INH poisoning.Vet Hum Toxicol. 1979;21:12-15.


Abstract Views: 276

PDF Views: 0




  • Acute Neurotoxicity with Appropriate Dose of Isoniazid: a Case Report

Abstract Views: 276  |  PDF Views: 0

Authors

N. M. Aleemuddin
Rajiv Gandhi Institute of Medical Sciences Adilabad 504001, A.P, India

Abstract


Isoniazid (INH) is most frequently used in combination with other drugs for the treatment of tuberculosis or as monotherapy for treatment of latent tuberculous infection. Seizures due to anti-tubercular chemotherapy are a rare side effect. INH causing status epilepticus has been very rarely reported to cause seizures. We present a patient who, after 5 months of treatment with appropriate dose of INH, evolved to status epilepticus. Seizures could be controlled only after administering of pyridoxine.

Keywords


Isoniazid, Acute Neurotoxicity, Status Epilepticus, Seizures, Pyridoxine

References