A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Narayanan, N.
- A Robust Clinical Information on King of Carotenoids: a Systematic Review of the Literature
Authors
1 Shield Health Care Pvt Ltd, Chennai-600095,Tamilnadu, IN
2 Periyar Maniammai UniversityThanjavur-613403,Tamilnadu, IN
Source
Indian Journal of Drugs and Diseases, Vol 1, No 1 (2012), Pagination: 18-25Abstract
Astaxanthin is a red carotenoid pigment extensively found in living organisms. Though Astaxanthin is a carotenoid compound, unlike β-carotene (a vitamin A precursor), cannot be converted to vitamin A. Astaxanthin, a potent antioxidant,with other biological effects protects cell membranes from harmful damage in the body. Studies suggest Astaxanthin may be effective in treating diseases, including cardiovascular, immune disorders, tumor, diabetes, neurodegenerative conditions and inflammatory conditions. Recent studies on Astaxanthin have shown enhancing immune response and decreasing DNA damage in humans. Astaxanthin is capable of crossing the blood-brain barrier in mammals.Keywords
Astaxanthin, Antioxidant, Immune ResponseReferences
- Aoi W, Naito Y, Takanami Y, Ishii T, Akagiri S, Kato Y, Osawa T and Yoshikawa T (2008). Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification. Biochem. Biophys. Res. Commun. 366(4),892-7. Epub 2007 Dec 17.
- Fassett RG, Coombes JS (2009) Astaxanthin, Oxidative stress, inflammation and cardiovascular disease. Future Cardiol. 5(4), 333-342.
- Ikeuchi M, Koyama T, Takahashi J and Yazawa K (2006) Effects of Astaxanthin supplementation on exercise-induced fatigue in mice. Biol. Pharm. Bull. 29(10), 2106-10.
- Ikeuchi M, Koyama T, Takahashi J and Yazawa K (2007) Effects of Astaxanthin in obese mice fed a high-fat diet. Biosci .Biochem. 71 (4), 893-9. Epub 2007 Apr 7.
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- Miyawaki et al., (2005) Effects of Astaxanthin on human blood rheology. J.Clin. Therap. Med. 21(4),421-429.
- Nagaki et al.(2005) The effect of Astaxanthin on retinal capillary blood flow in normal volanteers. J.Clin. Opthal.28(5),537-542.
- Nagaki et al., (2006) The supplementation effect of Astaxanthin on accommodative and asthennopia. J. Clin.Therap.Me.22(1),41-54.
- Nagaki Y et al., (2002) Effects of Astaxanthin on accommodation, critical flicker fusions, and pattern evoked potential in visual disply terminal workers. J.Trad. Med. 19(5), 170-173.
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- Nakamura et al.(2004) Changes in visual function following peroral Astaxanthin. Japan J. Clin.Ophtal. 58(6),1051-1054.
- Nitta et al. (2005) Effects of Astaxanthin on accommodation and asthenopia –dose finding study in healthy volenteers.J.Clin.Therap. Med.21(6),637- 650.
- Ohgami et al.(2003) Effects of Astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Invest. Opthal. Vis. Sci.44 (6), 2694-2701.
- Sawaki K et al. (2002) Sports performance benefits from taking natural Astaxanthin characterized by visual activity and muscle fatigue improvements in humans. J. Clin. Ther. Med. 18(9), 73-88.
- Shiratori et al. (2005) Effect of Astaxanthin on accommodation and asthenopia- Efficancy identification study in healthy volunteers. J.Clin.Therap.Med. 21 (5), 543- 556.
- Suzuki et al., (2006) Suppressive effects of Astaxanthin against rat endotoxin –induced uveitis by inhibiting the NF-kB signalling pathway.Exp.Eye Res.82,275-281.
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- Yoshida H, Yanai H, Ito K, Tomono Y, Koikeda T, Tsukahara H and Tada N (2009). Administration of natural Astaxanthin increases serum HDL-cholesterol and (2):520-523. Epub 2009 Oct 14.
- Formulation and in-vitro Drug Release for β-cyclodextrin Nanosphears using Emulsification Solvent-evaporation Method
Authors
1 Shield Health Care Pvt Ltd, Chennai-600095, IN
Source
Indian Journal of Innovations and Developments, Vol 1, No 2 (2012), Pagination: 64-67Abstract
This study gives information about the formulation of β-cylcodextrin nanosphere by emulsification solvent-evaporation method based on emulsifying an organic phase containing the β-cylcodextrin in an aqueous phase of pluronic-F68 as surfactant. The nanospheres are loaded with hydrophobic drug and the in-vitro drug release study was conducted. The formulation of colloidal particle was associated with amphiphilic properties of the β-cylcodextrin derivatives. However, the partitioning of the β- cyclodextrin between the organic and aqueous phases is always depends on the concentration of the surfactant. In the case of nanospheres loaded with Irinotican hydrochloride, the partitioning of the drug occurs between the dispersed phase containing β- cylcodextrin and the continuous aqueous phase containing pluronic-F68.Keywords
Amphiphilic Cyclodextrins, Emulsification, Solvent-evaporation Method, Nanospheres, Irinotecan, Surfactant, Pluronic-F68References
- Allemann E, Gurny R and Doelker E (1992) Preparation of aqueous polymeric nanodispersions by a reversible salting out process: influence of process parameters on particle size. Int. J.Pharm., 87, 247-253.
- Allemann E, Leroux JC, Gurny R and Doelker E (1993) In vitro extended-release properties of drug-loaded poly(DL-Lactide Acid) nanospheress produced by saltingout procedure. Pharm. Res., 10, 1732-1737.
- Al-Saden AA, Whateley TL and Florence AT (1982) Polaxamer Association in aqueous solution. J.Colloid Interface Sci., 90, 303-309.
- Bodmeier R and Chen H 1990 Indomethacin polymeric nanosupensions prepared by microfluidization. J. Controlled Release, 12, 223-233.
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- Bodmeier R and McGinity JW (1987b) Polylactide acid microspheres containing quinidine base and quinidine sulphate prepared by slovent evaporation techniquie. II. Some processes parameters influencing the preparation and properties of microspheres. J.Microencapsulation, 4, 289-297.
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- Formulation and evaluation of mucoadhesive buccal films of Diclofenac Sodium
Authors
1 Shield Health Care Pvt Ltd, Chennai-600095, IN
Source
Indian Journal of Innovations and Developments, Vol 1, No 2 (2012), Pagination: 68-73Abstract
Buccal drug delivery offers a safe and easy method of drug utilization, because drug absorption can be promptly terminated in case of toxicity by removing the dosage form from the buccal cavity. A buccal film for systemic administration of diclofenac sodium has been developed using hydroxyl propyl methylcellulose, poly vinyl pyrolidone, glycerin, eudragit and ethanol by solvent casting method. The prepared films characterized by means of film thickness, swelling capacity, in- vitro adhesion, drug release, weight variation, folding endurance, etc. The in vitro release studies were conducted for diclofenac sodium patches in phosphate buffer-pH-6.6 solution. The mechanism of release is diffusion process followed by first order kinetics. The formulated patches exhibit drug release in the range of 76.92 to 92.12% in four hours.Keywords
Mucoadhesive Film, Diclofenac Sodium, First Order Kinetics, in- vitro ReleaseReferences
- Agarwal SP, Alka Ahuja and Khanna R (1998) Mucoadhesive buccal drug delivery; A potential alternative to conventional therapy. J.Controlled Release, 1-11.
- Alka Ahuja, Javed ali and Khar RK (1998) Buccoadhesive films of Triamicinolone Acetonide. Development and Evaluation of a Buccoadhesive-erodible carrier for treatment of oral lesions. J.Controlled Release, 60(5), 322-325.
- Alka Ahuja, Khar RK and Javed Ali (1997) Mucoadhesive drug delivery system, Drug Development and Industrial Pharmacy. J.Controlled Release, 489-515.
- Goodman and Gillman (2001) The Pharmacological Basis of Therapeutics, 5-6.
- Ilango R, Jeyakar B, Kavimani S and Mullaicharam AR (1997) In-vivo studies on buccal strips of Glibenclamide using Chitosan. J.Controlled Release, 59, 232-235.
- Khanna R., Agarwal SP and Ahuja alka (1998) Mucoadhesive buccal drug delivery: A potential alternative to conventional therapy. J.Controlled Release, 60(1), 1-11.
- Pai M, Pandey S, Singh UV and Udupa (1998) Mucoadhesive Formulation of Theophylline, J.Controlled Release, 60(4), 241-243.
- Remington (2005) The science and practice of pharmacy, 1157.
- Saisivam S (2000) Design and Evaluation of Diltiazem Hydrochloride Buccal Patches. J.Controlled Release, 62, 236-238.
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- Health Assessment and Case Analysis of Diabetes in Rural Population of Thiruvallur District, Tamilnadu, India
Authors
1 Jaya College of Pharmacy, Thiruninravur - 602024, Chennai, Tamil Nadu, IN
2 Government College of Pharmacy, Madras Medical College, Chennai -600 003, IN
3 JSS Medical College for Ayurveda, Alanahally, Mysore - 570 028, IN
Source
Journal of Pharmaceutical Research, Vol 14, No 3 (2015), Pagination: 57-60Abstract
Purpose: WHO estimates that more than 346 million people worldwide have diabetes. Majority of the population today is not just trying to be economically successful but also aim to stay fit and free from dreaded chronic diseases. This investigation aims to evaluate the health conditions of people from remote areas who have less possibility of utilizing the urban health facilities of India. Methodology: A cross sectional study was conducted to clinically assess diabetes in rural population of Thiruvaliur district by using a predesigned and pretested protocol to find out the prevalence and the risk of diabetes mellitus in general population. The study mainly focuses on rural population so as to suggest possible treatment and remedial aspects. Various studies in the test used are based on simple anthropometric, demographic and behavioral factors to detect undiagnosed diabetes. The responses for the questions were collected, evaluated and statistically analyzed. Findings: Out of 250 subjects, only 5% showed symptoms of diabetes (first time diagnosis) and among them half were in the early stage of the disorder. Conclusion: This study reveals that diabetes awareness prevailed among selected individuals about the hygienic system and life style. It was found that people acquired maximum knowledge with better understanding of the disease, better impact on the progression of the disease and complications by patient counseling through verbal and pictograms.Keywords
Diabetes, Health Conditions, Rural Population, Anthropometric, Demographic.- Pharmacognostical and Antimicrobial Studies of the Stem Barks of Prosopis cineraria (L) Druce
Authors
1 Dept. of Pharmacognosy, Maharaji College of Pharmacy, Besant Nagar, Chennai–600 090, Tamil Nadu, IN
2 College of Pharmacy, Madras Medical College, Chennai-3, Tamil Nadu, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 3 (2009), Pagination: 227-231Abstract
Prosopis cineraria (L) Druce is one of the highly valued plant in the Indigenous System of Medicine. Its bark is said to be a potent drug for several ailments such as leprosy, dysentery, bronchitis, asthma, leucoderma, piles, muscular tremors, asthma, rheumatism and inflammations. It is also known to possess anthelmintic, antibacterial, antifungal, antiviral and anticancer activities. In view of its medicinal importance, the present research was focused on the pharmacognostical and antimicrobial properties of stem bark of P. cineraria by in vitro approach. Pharmacognostic investigation of the fresh, powdered and anatomical sections of the stem barks of P. cineraria was carried out to determine its macroscopical and microscopical characters along with the physico-chemical and preliminary phytochemical analysis. The antimicrobial activity of ethyl acetate and hydro alcoholic extracts of stem barks were evaluated against two Gram positive (Staphylococcus aureus, Staphylococcus epidermidis), two Gram negative (Escherichia coli, Klebsiella pneumoniae) bacterial strains and two fungal strains (Aspergillus niger, Aspergillus fumigatus) by agar disc diffusion method. Minimum Inhibitory Concentration (MIC) required for cessation of microbial growth was evaluated by agar streak dilution method. Both the extracts showed dose dependent activity against the microorganisms investigated. The hydroalcoholic extract exhibited significant activity against the test organisms than the ethyl acetate extract.Keywords
Prosopis cineraria, Antibacterial, Antifungal, Minimum Inhibitory Concentration (MIC), Stem Bark.- Pharmacognostical and Antimicrobial Studies of the Stem Barks of Prosopis cineraria (L) Druce
Authors
1 Dept. of Pharmacognosy, Maharaji College of Pharmacy, Besant Nagar, Chennai-600 090, Tamil Nadu, IN
2 College of Pharmacy, Madras Medical College, Chennai-3, Tamil Nadu, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 2 (2009), Pagination: 115-118Abstract
Prosopis cineraria (L) Druce is one of the highly valued plant in the Indigenous System of Medicine. Its bark is said to be a potent drug for several ailments such as leprosy, dysentery, bronchitis, asthma, leucoderma, piles, muscular tremors, asthma, rheumatism and inflammations. It is also known to possess anthelmintic, antibacterial, antifungal, antiviral and anticancer activities. In view of its medicinal importance, the present research was focused on the pharmacognostical and antimicrobial properties of stem bark of P. cineraria by in vitro approach. Pharmacognostic investigation of the fresh, powdered and anatomical sections of the stem barks of P. cineraria was carried out to determine its macroscopical and microscopical characters along with the physico-chemical and preliminary phytochemical analysis. The antimicrobial activity of ethyl acetate and hydro alcoholic extracts of stem barks were evaluated against two Gram positive (Staphylococcus aureus, Staphylococcus epidermidis), two Gram negative (Escherichia coli, Klebsiella pneumoniae) bacterial strains and two fungal strains (Aspergillus niger, Aspergillus fumigatus) by agar disc diffusion method. Minimum Inhibitory Concentration (MIC) required for cessation of microbial growth was evaluated by agar streak dilution method. Both the extracts showed dose dependent activity against the microorganisms investigated. The hydroalcoholic extract exhibited significant activity against the test organisms than the ethyl acetate extract.