International Journal of Physiology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Effect of Shift Work on Oxidative Stress


Affiliations
1 Assistant Professor, Department of Physiology, Pondicherry Institute of Medical Sciences, Ganapathychettikulam, Pondicherry
2 Associate Professor, Department of Physiology, SCB Medical College, Orissa
     

   Subscribe/Renew Journal


Shift workers due to altered circadian rhythm are more prone to various medical disorders when compared to others.This study was carried out to investigate whether shift work acts as an oxidative stressor. The study was conducted in day workers (n = 50) and night shift workers (n = 50) at Burla. Blood samples were collected for the estimation of free radicals&lipid profile Lipids, which undergo peroxidation are major targets of free radical attack. The production of MDA (malondialdehyde) was used as a biomarker to measure the level of oxidative stress. Study revealed that night shift work was a significant risk factor for high free radicals level which cause many medical disorders. The free radical levels were significantly more in smokers when compared to non smokers among the night shift workers. Thus, shift work act as an oxidative stressor.

Keywords

Shift Workers, Smokers, Oxidative Stress, Malondialdehyde
Subscription Login to verify subscription
User
Notifications
Font Size


  • Masoumeh Ghiasvand,Ramin Heshmat,Reza Golpira:shift work and risk of lipid disorders,American Journal of Epidemiology,2006

  • Pati AK,Chandrawshi A, Reinberg A. Shift work: consequence and management. Curr Sci. 2002;81:32–4

  • Williams C: Social factors, work, stress and cardiovascular disease prevention in the European Union Brussels: The European Heart Network;1998

  • Sjoblom TS, Kalimo R, et al.: Shift work, occupation and coronary disease – over 6 years of fallow up in the Helsinki heart study. Scand J Work Environ Health 1997, 23(4):257

  • Valko M. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Bi. 2007;39:44–84

  • Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 1990;186:1-85.

  • Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. 3rd ed.Oxford: Oxford University Press; 1999

  • Halliwell B. Antioxidants and human disease: a general introduction. Nutr Rev 1997;55:S44-49

  • Stoian I, Oros A, Moldoveanu E. Apoptosis and free radicals. Biochem Mol Med 1996;59:93-97.

  • Hampton MB, Orrenius S. Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett 1997;414:552-556.

  • Rivera-coll A, Funtes-Arderiu L, Diez-Noguera A. Circadian rhythmic variation in serum concentration of clinically important Lipids. Clin Chem. 1994;40:1549–1553.

  • Khoo NK ,Cantu- Medelline N et al,Obesity induced free radical generation. freeradbiomed. 2012;04:011.

  • Nakamura K, Shimai S, Kikuchi S, Tominaga K,Takahashi H, Tanaka M, Nakano S, Motohashi Y,Nakadaira H, Yamamoto M (1997) Shift work and risk factors for coronary heart disease in Japanese blue-collar workers: serum lipids and anthropometric characteristics. Occup Med (Lond) 47, 142.

  • Yagi K. Simple assay for the level of total lipid peroxides in serum or plasma. Methods Mol Biol. 1998;108:101–6

  • Philpot J.Assay for MDA levels.Rad Res 1963;3:55-8011.

  • Stocker R. Role of oxidative modifications in atherosclerosis. Physiol. Rev. 2004;84:1381–1478.

  • Keevil J.G. Implications of cardiac risk and lowdensity lipoprotein cholesterol distributions in the United States for the diagnosis and treatment of dyslipidemia: data from National Health and Nutrition Examination Survey 1999 to 2002. Circulation. 2007;115:1363–1370.

  • Parthasarathy S. High density lipoprotein inhibits the oxidative modification of low density lipoprotein. Biochim. Biophys. Acta. 1990;1044:275–283.

  • Engelmann B. Changes of membrane phospholipid composition of human erythrocytes in hyperlipidemias.Biochim. Biophys. Acta.

  • ;1165:32–37.20..Stocker R. Role of oxidative modifications in atherosclerosis. Physiol. Rev. 2004;84:1381–14787

  • Frei B, Forte TM, Ames BN, Cross CE. Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Biochem J 1991;277:133-138.

  • Pré J, Floch AL. Lipid-peroxidation products and antioxidants in plasma of cigarette smokers [Tech Brief]. Clin Chem 1990;36:1849-1850


Abstract Views: 425

PDF Views: 0




  • Effect of Shift Work on Oxidative Stress

Abstract Views: 425  |  PDF Views: 0

Authors

R V Hemamalini
Assistant Professor, Department of Physiology, Pondicherry Institute of Medical Sciences, Ganapathychettikulam, Pondicherry
Arpita Priyadarshini
Associate Professor, Department of Physiology, SCB Medical College, Orissa

Abstract


Shift workers due to altered circadian rhythm are more prone to various medical disorders when compared to others.This study was carried out to investigate whether shift work acts as an oxidative stressor. The study was conducted in day workers (n = 50) and night shift workers (n = 50) at Burla. Blood samples were collected for the estimation of free radicals&lipid profile Lipids, which undergo peroxidation are major targets of free radical attack. The production of MDA (malondialdehyde) was used as a biomarker to measure the level of oxidative stress. Study revealed that night shift work was a significant risk factor for high free radicals level which cause many medical disorders. The free radical levels were significantly more in smokers when compared to non smokers among the night shift workers. Thus, shift work act as an oxidative stressor.

Keywords


Shift Workers, Smokers, Oxidative Stress, Malondialdehyde

References