International Journal of Physiology

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Effect of Shift Work on Oxidative Stress


Affiliations
1 Assistant Professor, Department of Physiology, Pondicherry Institute of Medical Sciences, Ganapathychettikulam, Pondicherry
2 Associate Professor, Department of Physiology, SCB Medical College, Orissa
     

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Shift workers due to altered circadian rhythm are more prone to various medical disorders when compared to others.This study was carried out to investigate whether shift work acts as an oxidative stressor. The study was conducted in day workers (n = 50) and night shift workers (n = 50) at Burla. Blood samples were collected for the estimation of free radicals&lipid profile Lipids, which undergo peroxidation are major targets of free radical attack. The production of MDA (malondialdehyde) was used as a biomarker to measure the level of oxidative stress. Study revealed that night shift work was a significant risk factor for high free radicals level which cause many medical disorders. The free radical levels were significantly more in smokers when compared to non smokers among the night shift workers. Thus, shift work act as an oxidative stressor.

Keywords

Shift Workers, Smokers, Oxidative Stress, Malondialdehyde
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  • Effect of Shift Work on Oxidative Stress

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Authors

R V Hemamalini
Assistant Professor, Department of Physiology, Pondicherry Institute of Medical Sciences, Ganapathychettikulam, Pondicherry
Arpita Priyadarshini
Associate Professor, Department of Physiology, SCB Medical College, Orissa

Abstract


Shift workers due to altered circadian rhythm are more prone to various medical disorders when compared to others.This study was carried out to investigate whether shift work acts as an oxidative stressor. The study was conducted in day workers (n = 50) and night shift workers (n = 50) at Burla. Blood samples were collected for the estimation of free radicals&lipid profile Lipids, which undergo peroxidation are major targets of free radical attack. The production of MDA (malondialdehyde) was used as a biomarker to measure the level of oxidative stress. Study revealed that night shift work was a significant risk factor for high free radicals level which cause many medical disorders. The free radical levels were significantly more in smokers when compared to non smokers among the night shift workers. Thus, shift work act as an oxidative stressor.

Keywords


Shift Workers, Smokers, Oxidative Stress, Malondialdehyde

References