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Study of Prognostic Factors affecting on the IUI Outcome of Infertile Patients


Affiliations
1 University of Kufa, Faculty of Science Department of Biology, Najaf, Iraq
2 Department of Drugs and Toxins – College of Pharmacy–Kufa University, Iraq
     

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Objective: The main objective of the study is to determine of prognostic factors on the pregnancy rate after intrauterine insemination (IUI) of infertile patients. Methods: The study was carried out between January 2014 and October 2014 including one hundred and fifty five infertile men who attended the Fertility Center in Al – Sadr Medical City. Results: The of the study showed that there was statistically significant (p<0.01) increase in pregnancy rate with couples that had sperm concentration ≥20 × 106/ml, progressive motility (A +B) ≥ 50 % and normal morphology ≥ 30% as well as couples with leukocyte concentration < 1×106 /ml, MDA concentration < 4 μmol/L and sperm chromatin maturity < 30%. This results also appeared higher significant (p<0.01) with couples that had age <30 years, infertility duration < 6 years and with couples non – smokers compared to smokers. While no significant difference (p> 0.01) was showed with type of infertility. Conclusion: Many factors may influence success rate after IUI treatment procedures such as potential sperm parameters, leukocyte concentration, MDA concentration and sperm chromatin maturity as well as age, infertility duration and smoking. Recommendation: Advance study to determine of the effect female factors on the IUI outcome.

Keywords

Infertility, IUI, Sperm Parameters, Leukocyte Concentration, Sperm Chromatin Maturity.
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  • Study of Prognostic Factors affecting on the IUI Outcome of Infertile Patients

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Authors

Mohsin K. Al- Murshdi
University of Kufa, Faculty of Science Department of Biology, Najaf, Iraq
Yahya K. Al – Sultani
Department of Drugs and Toxins – College of Pharmacy–Kufa University, Iraq

Abstract


Objective: The main objective of the study is to determine of prognostic factors on the pregnancy rate after intrauterine insemination (IUI) of infertile patients. Methods: The study was carried out between January 2014 and October 2014 including one hundred and fifty five infertile men who attended the Fertility Center in Al – Sadr Medical City. Results: The of the study showed that there was statistically significant (p<0.01) increase in pregnancy rate with couples that had sperm concentration ≥20 × 106/ml, progressive motility (A +B) ≥ 50 % and normal morphology ≥ 30% as well as couples with leukocyte concentration < 1×106 /ml, MDA concentration < 4 μmol/L and sperm chromatin maturity < 30%. This results also appeared higher significant (p<0.01) with couples that had age <30 years, infertility duration < 6 years and with couples non – smokers compared to smokers. While no significant difference (p> 0.01) was showed with type of infertility. Conclusion: Many factors may influence success rate after IUI treatment procedures such as potential sperm parameters, leukocyte concentration, MDA concentration and sperm chromatin maturity as well as age, infertility duration and smoking. Recommendation: Advance study to determine of the effect female factors on the IUI outcome.

Keywords


Infertility, IUI, Sperm Parameters, Leukocyte Concentration, Sperm Chromatin Maturity.

References