Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Antiepileptic Activity of Ethanolic and Aqeous Leaves Extract of Annona reticulata Linn


Affiliations
1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, India
     

   Subscribe/Renew Journal


The present study was evaluated for the Antiepileptic activity of methanolic and aqeous extracts of leaves Annona reticulata on the seizures induced by chemical and electroconvulsive method i.e PTZ and MES methods. In this study, the antiepileptic study of methanolic and aqeous extract of Annona reticulata at doses of 100mg/kg, 200mg/kg and 400mg/kg using the PTZ and MES models were investigated in Swiss Albino Rats. The %protection of the rats was found to increase with an increase in the dose. It was found that at the dose of 400mg/kg, both the extract of the leaves showed very good activity and most animals showed no signs of convulsions. The obtained data from the study suggested the reduction in the duration and delay in the latency of the seizures.

Keywords

Annona Reticulata, Antiepileptic Activity, MES, PTZ.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Porwal M, Sharma K.Evaluation of anticonvulsant activity of Annona squamosa linn. leaves in mice. J Cell Tissue Res. 2011;11(2):2879-2884.

  • Hoareau L, DaSilva EJ. Medicinal plants: a re-emerging health aid. Plant Biotechnol J. 1999; 2(2): 56-70.

  • Verma S, Singh SP. Current and future status of herbal medicines. Veterinary World. 1(11): 347-350.

  • Rao S, Subbalakshmi K. An experimental study of the anticonvulsant effect of amlodipine in mice. Singapore Med J 2010; 51(5): 424-8.

  • Jhamkhande PS, Wattamwar AS, Chandak PG.The invitro anthelmintic efficacy of ethno-medicinal plant Annona reticulata ischolar_mains against Indian earthworms. IJNPR. 2014; 5(2):152-157.

  • Thang TD, Kuo PC, Huang GJ, Hung NH, Huang BS, Yang ML et al. Chemical constituents from the leaves of Annonareticulata and their inhibitory effects on NO production. Molecules. 2013;18:4477-4486.

  • Devasagayam TPA, Tilak JC and Boloor KK, Free Radicals and antioxidants in human health: current status and future prospects, JAPI, 2004; 52: 794-804.

  • New OECD 425 Guidelines. OECD guidelines for testing of Animals. 2001:1-26.

  • Girish SA, Sudhir G, Wadodkar, Avinash KD. Evaluation of sedative and anticonvulsant activities of UnmadnashakGhrita. J Ethnopharmacol. 2004; 94: 77-83.

  • Suresh AR, Karki SS. Anticonvulsant activity of various extracts of leaves of Calotropisgigantea Linn. against seizure induced models. Int J Pharm Sci. 2011; 3(3): 200-203.


Abstract Views: 237

PDF Views: 0




  • Antiepileptic Activity of Ethanolic and Aqeous Leaves Extract of Annona reticulata Linn

Abstract Views: 237  |  PDF Views: 0

Authors

Sonal D’Souza
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, India
Jennifer Fernandes
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, India
M. Vijay Kumar
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, India
Nishmitha Gretta D’Souza
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, India
Ronald Fernandes
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, India

Abstract


The present study was evaluated for the Antiepileptic activity of methanolic and aqeous extracts of leaves Annona reticulata on the seizures induced by chemical and electroconvulsive method i.e PTZ and MES methods. In this study, the antiepileptic study of methanolic and aqeous extract of Annona reticulata at doses of 100mg/kg, 200mg/kg and 400mg/kg using the PTZ and MES models were investigated in Swiss Albino Rats. The %protection of the rats was found to increase with an increase in the dose. It was found that at the dose of 400mg/kg, both the extract of the leaves showed very good activity and most animals showed no signs of convulsions. The obtained data from the study suggested the reduction in the duration and delay in the latency of the seizures.

Keywords


Annona Reticulata, Antiepileptic Activity, MES, PTZ.

References