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Antiepileptic Activity of Ethanolic and Aqeous Leaves Extract of Annona reticulata Linn


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1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, India
     

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The present study was evaluated for the Antiepileptic activity of methanolic and aqeous extracts of leaves Annona reticulata on the seizures induced by chemical and electroconvulsive method i.e PTZ and MES methods. In this study, the antiepileptic study of methanolic and aqeous extract of Annona reticulata at doses of 100mg/kg, 200mg/kg and 400mg/kg using the PTZ and MES models were investigated in Swiss Albino Rats. The %protection of the rats was found to increase with an increase in the dose. It was found that at the dose of 400mg/kg, both the extract of the leaves showed very good activity and most animals showed no signs of convulsions. The obtained data from the study suggested the reduction in the duration and delay in the latency of the seizures.

Keywords

Annona Reticulata, Antiepileptic Activity, MES, PTZ.
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  • Antiepileptic Activity of Ethanolic and Aqeous Leaves Extract of Annona reticulata Linn

Abstract Views: 244  |  PDF Views: 0

Authors

Sonal D’Souza
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, India
Jennifer Fernandes
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, India
M. Vijay Kumar
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, India
Nishmitha Gretta D’Souza
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, India
Ronald Fernandes
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, India

Abstract


The present study was evaluated for the Antiepileptic activity of methanolic and aqeous extracts of leaves Annona reticulata on the seizures induced by chemical and electroconvulsive method i.e PTZ and MES methods. In this study, the antiepileptic study of methanolic and aqeous extract of Annona reticulata at doses of 100mg/kg, 200mg/kg and 400mg/kg using the PTZ and MES models were investigated in Swiss Albino Rats. The %protection of the rats was found to increase with an increase in the dose. It was found that at the dose of 400mg/kg, both the extract of the leaves showed very good activity and most animals showed no signs of convulsions. The obtained data from the study suggested the reduction in the duration and delay in the latency of the seizures.

Keywords


Annona Reticulata, Antiepileptic Activity, MES, PTZ.

References