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DNA Binding And Antimicrobial Activity of Cobalt (III) Complex Containing 2,2’ Bipyridyl and 8-Hydroxy Quinoline as Ligands


Affiliations
1 Department of Chemistry, Thiruvalluvar University, Vellore – 632115. Tamilnadu, India
2 Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam - 638401. Tamilnadu, India
     

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In this paper cobalt complex of type [Co(Bipy)2(8HQ)](ClO4)2 [Bipy = 2,2’-bipyridyl, HQ = 8-Hydroxy Quinoline) has been synthesized and characterized by elemental analyses, NMR, UV-visible, infrared spectral studies. DNA binding properties of this metal complex was investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and cyclic voltammetry. The experimental results indicate that the complex bind to DNA through an intercalative mode. The complex tested for biological activity and it has good antibacterial and antifungal activity on comparing with standard drugs.

Keywords

DNA Binding, Cobalt(III) Complex, Antimicrobial Activity, 8-Hydroxy Quinoline.
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  • DNA Binding And Antimicrobial Activity of Cobalt (III) Complex Containing 2,2’ Bipyridyl and 8-Hydroxy Quinoline as Ligands

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Authors

S. Dhakshanamoorthy
Department of Chemistry, Thiruvalluvar University, Vellore – 632115. Tamilnadu, India
N. Sri Gayathrai Devi
Department of Chemistry, Thiruvalluvar University, Vellore – 632115. Tamilnadu, India
M. Murali Krishnan
Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam - 638401. Tamilnadu, India
M. N. Arumugham
Department of Chemistry, Thiruvalluvar University, Vellore – 632115. Tamilnadu, India

Abstract


In this paper cobalt complex of type [Co(Bipy)2(8HQ)](ClO4)2 [Bipy = 2,2’-bipyridyl, HQ = 8-Hydroxy Quinoline) has been synthesized and characterized by elemental analyses, NMR, UV-visible, infrared spectral studies. DNA binding properties of this metal complex was investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and cyclic voltammetry. The experimental results indicate that the complex bind to DNA through an intercalative mode. The complex tested for biological activity and it has good antibacterial and antifungal activity on comparing with standard drugs.

Keywords


DNA Binding, Cobalt(III) Complex, Antimicrobial Activity, 8-Hydroxy Quinoline.

References