Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Biochemical variability of Vitamin D Receptor (VDR) Gene and its Relationship with Bone Mineral Density in Children of the Western Region of the Republic of Kazakhstan


Affiliations
1 Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan
     

   Subscribe/Renew Journal


25-OH vitamin D deficiency in children and adolescents can impair mineral metabolism in bone tissue. There are 3 possible vitamin D receptor genotypes: Tt, Tc and Cc. A link between low levels of this vitamin and increased bone fragility was previously described. However, a clear pattern between the vitamin uptake and the musculoskeletal system state was not always observed. Vitamin D receptor gene polymorphism which is slightly different among representatives of Russian and Kazakh ethnic groups suggests the differences in the uptake of the biologically active substance in children. VDRs are located in many human organs and systems. They regulate the gene transcription and are also involved in many chemical reactions. Conditionally healthy children, representatives of different ethnic groups were selected for this study. Special laboratory conditions provided reliable data on the level of vitamin D in each child studied. We also compiled a number of tables and graphs that illustrate the prevalence of VDR genotypes, the frequency of different receptors in normal, osteopenic and osteoporotic signs of bone mineral density.

Keywords

Adolescents, Musculoskeletal System, Bone Tissue, Biochemical Polymorphism.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Kishkun AA. Vitamin D: from the marker of bone and mineral metabolism to the indicator of general health. Clinical Laboratory Diagnostics 10, 2011: 38-45.

  • Semin SG, Volkova LV, Moiseyev AB, Nikitina NV. Prospects for studying the biological role of vitamin D. Pediatrics 91(2), 2012: 122-131.

  • Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol 21(3), 2014: 319-29

  • Vertkin A.L., Naumov A.V. Osteoporosis. Eksmo-Press, Moscow. 2015, pp. 34-38.

  • Ministry of Health of the Russian Federation. Clinical recommendations. Osteoporosis. 2016. Available from: URL: https://www.endocrincentr.ru/sites/default/files/specialists/science/clinic-recomendations/rec_osteoporosis_2016.pdf

  • Norman AW, Bouillon R. Vitamin D nutritional policy needs a vision for the future. Exp. Biol. Med. 235 (9), 2010: 1034-1045.

  • Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev. 26, 2005: 662-687.

  • Zakharova I.N. Known and unknown effects of vitamin D. Questions of Modern Pediatrics 12 (2), 2013: 20-25.

  • Sychev DA, Ramenskaya GV, Ignatiev IV, Kukes VG. Clinical head-makogenetika. GEOTAR-Media, Moscow. 2007, pp. 19-27.

  • Baim S, Leonard MB, Bianchi ML, Hans DB, Kalkwarf HJ, Langman CB, Rauch F. Official Positions and Pediatric Official Positions of The International Society for Clinical Densitometry (ISCD). J Clin Densitom 11(1), 2008: 6-21.

  • Kanis J, Borgstrom F, Zethraeus N. Intervention thresholds for osteoporosis in the UK. Bone 36; 2005: 22-32.

  • Holick MF, Binkley NC, Bischoff-Ferrari HA. Evaluation, Treatment and Prevebtion of Vitamin D Deficiency: an Endocrin Society clinical Practice Guideline. Journal of Clinical Endocrinology & Metabolism 96 (7), 2011: 1911-1930.

  • Chernosha DA, Kanashkova TA. H-49 Methods of immunoassay based on the use of labeled components. BSMU, Minsk. 2007, 28 p.

  • Kokabas А, Karaguzel G, Imir N, Yavuzer U, Akcurin S. Effect of vitamin receptor gene polymorphisms on susceptibility to disease, and bone mineral density in Turkish patients with type 1 diabetes. Journal of Pediatrics endokrin.metab. 23 (12); 2010: 1289-97.

  • Randerson-Moor JA, Taylor JC, Elliot F, Chang YM, Besvic S, Kukalizch K. Vitamin D receptor gene polymorphisms, serum levels of 25-hydroxyvitamin D and melanoma: a case-control comparison of UK and meta-analysis of published data VDR. EurJCancer. 45(18), 2009: 3271-81.

  • Mamaev AN. Fundamentals of Medical Statistics. Prakticheskaya Meditsina, Moscow. 2011, pp. 89-93

  • Benevolenskaya LI, Lesnyak OM. Osteoporosis. Diagnosis, prevention and treatment. GEOTAR-Media, Moscow. 2005, pp. 69-73.

  • Korotkova ТА. Characteristics of bone tissue in adolescents according to the assessment of mineralization: Author's abstract. dis. ... the candidate of medical sciences. Institute of Rheumatology, Moscow. 2007, p. 27-29.

  • Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 20; 2009: 1807–182.

  • Ross AC, Manson JE, Abrams SA. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. Journal of Clinical Endocrinology and Metabolism, 96(1); 2011: 53–58.

  • El-Hajj Fuleihan G. Vitamin D deficiency in the Middle East and its health consequences. Clin Rev Bone Miner Metab 7; 2009: 77–93.

  • Thorne-Lyman A, Fawzi WW. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatr Perinat Epidemiol. 1, 2012: 75-90. doi: 10.1111/j.1365- 3016.2012.01283.x.


Abstract Views: 223

PDF Views: 0




  • Biochemical variability of Vitamin D Receptor (VDR) Gene and its Relationship with Bone Mineral Density in Children of the Western Region of the Republic of Kazakhstan

Abstract Views: 223  |  PDF Views: 0

Authors

Ainur Amanzholkyzy
Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan
Roza E. Nurgaliyeva
Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan
Aiman T. Kaldybayeva
Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan
Tamara Zh. Batyrova
Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan
Farida K. Balmaganbetova
Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan
Zhuldyz A. Aibassova
Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan

Abstract


25-OH vitamin D deficiency in children and adolescents can impair mineral metabolism in bone tissue. There are 3 possible vitamin D receptor genotypes: Tt, Tc and Cc. A link between low levels of this vitamin and increased bone fragility was previously described. However, a clear pattern between the vitamin uptake and the musculoskeletal system state was not always observed. Vitamin D receptor gene polymorphism which is slightly different among representatives of Russian and Kazakh ethnic groups suggests the differences in the uptake of the biologically active substance in children. VDRs are located in many human organs and systems. They regulate the gene transcription and are also involved in many chemical reactions. Conditionally healthy children, representatives of different ethnic groups were selected for this study. Special laboratory conditions provided reliable data on the level of vitamin D in each child studied. We also compiled a number of tables and graphs that illustrate the prevalence of VDR genotypes, the frequency of different receptors in normal, osteopenic and osteoporotic signs of bone mineral density.

Keywords


Adolescents, Musculoskeletal System, Bone Tissue, Biochemical Polymorphism.

References