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Biochemical variability of Vitamin D Receptor (VDR) Gene and its Relationship with Bone Mineral Density in Children of the Western Region of the Republic of Kazakhstan


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1 Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan
     

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25-OH vitamin D deficiency in children and adolescents can impair mineral metabolism in bone tissue. There are 3 possible vitamin D receptor genotypes: Tt, Tc and Cc. A link between low levels of this vitamin and increased bone fragility was previously described. However, a clear pattern between the vitamin uptake and the musculoskeletal system state was not always observed. Vitamin D receptor gene polymorphism which is slightly different among representatives of Russian and Kazakh ethnic groups suggests the differences in the uptake of the biologically active substance in children. VDRs are located in many human organs and systems. They regulate the gene transcription and are also involved in many chemical reactions. Conditionally healthy children, representatives of different ethnic groups were selected for this study. Special laboratory conditions provided reliable data on the level of vitamin D in each child studied. We also compiled a number of tables and graphs that illustrate the prevalence of VDR genotypes, the frequency of different receptors in normal, osteopenic and osteoporotic signs of bone mineral density.

Keywords

Adolescents, Musculoskeletal System, Bone Tissue, Biochemical Polymorphism.
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  • Biochemical variability of Vitamin D Receptor (VDR) Gene and its Relationship with Bone Mineral Density in Children of the Western Region of the Republic of Kazakhstan

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Authors

Ainur Amanzholkyzy
Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan
Roza E. Nurgaliyeva
Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan
Aiman T. Kaldybayeva
Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan
Tamara Zh. Batyrova
Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan
Farida K. Balmaganbetova
Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan
Zhuldyz A. Aibassova
Department of Normal Physiology, West Kazakhstan Marat Ospanov State Medical University 030000, 68 Maresiev Str., Aktob, Kazakhstan

Abstract


25-OH vitamin D deficiency in children and adolescents can impair mineral metabolism in bone tissue. There are 3 possible vitamin D receptor genotypes: Tt, Tc and Cc. A link between low levels of this vitamin and increased bone fragility was previously described. However, a clear pattern between the vitamin uptake and the musculoskeletal system state was not always observed. Vitamin D receptor gene polymorphism which is slightly different among representatives of Russian and Kazakh ethnic groups suggests the differences in the uptake of the biologically active substance in children. VDRs are located in many human organs and systems. They regulate the gene transcription and are also involved in many chemical reactions. Conditionally healthy children, representatives of different ethnic groups were selected for this study. Special laboratory conditions provided reliable data on the level of vitamin D in each child studied. We also compiled a number of tables and graphs that illustrate the prevalence of VDR genotypes, the frequency of different receptors in normal, osteopenic and osteoporotic signs of bone mineral density.

Keywords


Adolescents, Musculoskeletal System, Bone Tissue, Biochemical Polymorphism.

References