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In vitro Antihyperglycemic Activity of Unripe Fruits Extracts of Artocarpus gomezianus


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1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, India
     

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Diabetes mellitus is a metabolic disorder which results from defects in insulin secretion. Among the various methods of diabetes management, herbal products are best alternative drug with zero side-effects. The aim of this work was to assess the phytochemicals qualitatively and to evaluate the anti-diabetic activity of unripe fruits extract of Artocarpus gomezianus. The in vitro alpha-amylase and alpha-glucosidase inhibitory studies were performed using different concentration of extract and compared with a standard drug. Our assay result suggests that methanolic extract of Artocarpus gomezianus exhibit dose-dependent increase in percentage inhibitory activity on α-glucosidase enzymes (IC50 is 70.29) and α-amylase (IC50 is 68.75). Acarbose was used as a standard drug.

Keywords

in vitro Antidiabetic, Artocarpus gomezianus, α-Glucosidase, α-Amylase Enzymes.
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  • Krishnamoorthy SR, Sarala P. Phytochemical studies of Artocarpus gomezianus wall. ex Trecul. var. lakoocha Roxb. fruits collected from various altitudes of central western ghats. Indian Journal of Natural Products and resources.2013, 4(4): 398-411

  • Taksim Ahmed, Mohammad Nasir Uddin, Shaikh Faisol Ahmed, Arindam saha, Kaniz Farhana, Md.Sohel Rana. Invitro evaluation of antioxidant potential of Artocarpus charma Buch. fruits. Journal of Applied Pharmaceutical Sciences 2012, 2(10): 75-80.

  • Hashim NM, Mawardi Rahmani, Cheng LE, Sukari MA, Maizatulakmal Yahayu, Muhamad AMA, Ali AM, Rusea G. Antioxidant, Antimicrobial and tyrosinase inhibitory Activities of xanthones isolated from Artocarpus obtusus F.M. Jarrett: Molecules. 2012, 17, 6071-6082.

  • Unnikrishnan PS, Suthindhiran K, Jayasri M. Alpha-amylase inhibition and antioxidant activity of marine green algae and its possible role in diabetes management. Pharmacog. Mag. 2015 Oct, 11(4): S511-S515.

  • Madhusudhan Telagari and Kiran Kumar Hullatti. In vitro α-amylase and α-glucosidase inhibitory activity of Adiantum caudatum Linn. and Celosia argentea Linn. Extracts and fractions. Indian Journal of Pharmacology. 2015 Jul-Aug, 47(4):425-429.


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  • In vitro Antihyperglycemic Activity of Unripe Fruits Extracts of Artocarpus gomezianus

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Authors

Jennifer Fernandes
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, India
Ronald Fernandes
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, India
M. Vijay Kumar
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, India
K. Rajisha
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, India
Ryna V. Lobo
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, India

Abstract


Diabetes mellitus is a metabolic disorder which results from defects in insulin secretion. Among the various methods of diabetes management, herbal products are best alternative drug with zero side-effects. The aim of this work was to assess the phytochemicals qualitatively and to evaluate the anti-diabetic activity of unripe fruits extract of Artocarpus gomezianus. The in vitro alpha-amylase and alpha-glucosidase inhibitory studies were performed using different concentration of extract and compared with a standard drug. Our assay result suggests that methanolic extract of Artocarpus gomezianus exhibit dose-dependent increase in percentage inhibitory activity on α-glucosidase enzymes (IC50 is 70.29) and α-amylase (IC50 is 68.75). Acarbose was used as a standard drug.

Keywords


in vitro Antidiabetic, Artocarpus gomezianus, α-Glucosidase, α-Amylase Enzymes.

References