Research Journal of Pharmacy and Technology

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Synthesis and Characterization of Some new Heterocyclic Compounds Containing a Sulfonamide Moiety


Affiliations
1 Department of Chemistry, College of Education for Girls, University of Kufa, Iraq
     

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This study deliberates a sequence of 3-hydroxy-4-aminobenzene sulfonamide derivatives. In the present investigation 3-hydroxy-4-aminobenzene sulfonamide has been taken as initial material and treated with acetylacetone to prepare new azo compound then azo compound reacts with p-chloro benzaldehyde in absolute ethanol to prepare chalcone derivatives then chalcone derivatives react with various compounds such as urea thiourea, quandin, Meldrum's acid, barbituric acid, hydroxyl amine hydrochloride, 2,4-dinitrophenyl hydrazine to prepare new heterocyclic compound.

Keywords

4-Aminobenzene Sulfonamide, Azo Compound, Chalcone Derivatives, Heterocyclic Compounds.
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  • Eicher T, Hauptmann S. The Chemistry of Heterocycles. Wiley-VCH. Weinheim. 2003.

  • Difiore A, Monti SM, Innocenti, A Winuma, JY; De Simone G and Supuran CT. Carbonic anhydrase inhibitors: Crystallographic and solution binding studies for the interaction of a boron containing aromatic sulfonamide with mammalian isoforms I–XV. Bioorganic and Medicinal Chemistry Letters. 2010; 20: 3601–3605.

  • Smaine, FZ, Pacchiano F, Rami M, Barragan-Montero, V, Vullo D, Scozzafava A, Winuma, JY and Supuran, C.T. Carbonic anhydrase inhibitors: 2-Substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. Bioorganic and Medicinal Chemistry Letters. 2008; 18: 6332–6335.

  • Ali A, Reddy GSKK, Cao H and other. Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl oxazolidinone-5-carboxamides as novel p2 ligands. Journal of Medicinal Chemistry. 2006, 49(25): 7342–7356,

  • Sondhi, SM, Johar M, Singhal N, Dastidar SG, Shukla R, and Raghubir R. Synthesis and anticancer, anti-inflammatory and analgesic activity evaluation of some drugs and acridine derivatives. Monatshefte für Chemie. 2000; 131: 511–520.

  • Dow RL, Paight ES, Schneider SR, Hadcock JR, Hargrove, DM, Martin, KA, Maurer TS, Nardone NA, Tess DA, DaSilva-Jardinea P. Potent and selective, sulfamide-based human β3-adrenergic receptor agonists. Bioorganic and Medicinal Chemistry Letters. 2004, 14: 3235–3240.

  • Patel SD, Habeski WM, Cheng AC delacruz, E, Loh C, Kablaoui NM. Quinazolin-4- piperidin-4-methyl sulfamide PC-1 inhibitors: Alleviating hERG interactions through structure based design. Bioorganic and Medicinal Chemistry Letters. 2009, 19: 3339–3343.

  • Ezabadi IR, Canoutsis C, Zoumpoulakis P, Geronikaki A, Sokovic M, Glamocilija J, Ciric A. Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: Synthesis, biological evaluation, lipophilicity, and conformational studies. Bioorganic and Medicinal Chemistry Letters. 2008, 16: 1150–1161.

  • Chen Z, Xu W, Liu K, Yang S, Fan H, Bhadury PS, Hu DY, Zhang Y. Synthesis and antiviral activity of 5-(4-chlorophenyl)-1,3,4 -thiadiazole sulfonamides. Molecules. 2010, 15: 9046–9056.

  • Kiran VM. Studies on some isoxazoline-azo compounds and their colourant performance and fastness evaluation on synthetic fabric. International Journal of Chem Tech Research.2012; 4(1): 409-414.

  • Mouayad NM. Preparation, characterization and biological activity studies of new azo compounds. J. Chem. Chem. Eng. 2012; 6: 885-888.

  • Amita SR, Simon L, Srinivasan K, Sudheer M, Haleem Z, Shivender J, Ram M and Ravivarma S. Synthesis and in vitro antimicrobial evaluation of 5'-acetamido-2'-hydroxy chalcone derivatives. Research Journal of Chemical Sciences. 2014; 4(2): 56-59.

  • Yadav H, Gupta P, Pawar P, Singour P and Patil U. Synthesis and biological evaluation of anti-inflammatory activity of 1, 3-diphenyl propenone derivatives. Medicinal Chemistry Research.2010; 9: 1-8.

  • Monica K, Rakesh P and Yadavendra Y. Synthesis and biological activities of some new pyrimidine derivatives from chalcones. Der Pharma Chemica. 2014 6(2):352-359.

  • Tan ND and Dao TT. Synthesis, antioxidant and antimicrobial activities of a novel Series of chalcones, pyrazolic chalcones, and allylic chalcones. Pharmacology and Pharmacy. 2011; 2: 282-288.

  • Hery S, Jumina M, Alfinda NK and Ni-Nyoman, TP. Chalcones: synthesis, structure diversity and pharmacological aspects. Journal of Chemical and Pharmaceutical Research. 2014; 6(5): 1076-1088.


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  • Synthesis and Characterization of Some new Heterocyclic Compounds Containing a Sulfonamide Moiety

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Authors

Hanan Falah Mohsein
Department of Chemistry, College of Education for Girls, University of Kufa, Iraq
Nadia Sadiq Majeed
Department of Chemistry, College of Education for Girls, University of Kufa, Iraq
Thanaa Abed Al-Ameerhelal
Department of Chemistry, College of Education for Girls, University of Kufa, Iraq

Abstract


This study deliberates a sequence of 3-hydroxy-4-aminobenzene sulfonamide derivatives. In the present investigation 3-hydroxy-4-aminobenzene sulfonamide has been taken as initial material and treated with acetylacetone to prepare new azo compound then azo compound reacts with p-chloro benzaldehyde in absolute ethanol to prepare chalcone derivatives then chalcone derivatives react with various compounds such as urea thiourea, quandin, Meldrum's acid, barbituric acid, hydroxyl amine hydrochloride, 2,4-dinitrophenyl hydrazine to prepare new heterocyclic compound.

Keywords


4-Aminobenzene Sulfonamide, Azo Compound, Chalcone Derivatives, Heterocyclic Compounds.

References