Research Journal of Pharmacy and Technology

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Formulation and Evaluation of Chewable Tablets of Anti-asthmatic Drug


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1 Kamla Nehru college of pharmacy, Butibori Nagpur 441 108, India
     

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Montelukastsodium is a selective, orally acting leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis. In addition, patients with asthma need fast and immediate action of drug and avoidance of water is also desirable. Further, chewable tablets are beneficial for patients having difficulty in swallowing. The objective of the present study was to develop chewable tablets containing different compositions of ingredients by using direct compression method. Microcrystalline cellulose, mannitol, magnesium stearate, cross povidone and aspartame were used in the formulation in different concentrations. The prepared tablets were evaluated for various parameters like weight variation, thickness, friability, drug content, and in-vitro drug release. The in-vitro release study of formulation F7 was found to show 98% drug release in 30 minutes and stability studies showed no significant changes.

Keywords

Chewable tablets, Montelukast sodium, Direct compression method, Cross povidone, Stability study
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  • Formulation and Evaluation of Chewable Tablets of Anti-asthmatic Drug

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Authors

Suruse P. B
Kamla Nehru college of pharmacy, Butibori Nagpur 441 108, India
Band K. S
Kamla Nehru college of pharmacy, Butibori Nagpur 441 108, India
Ingole A. R
Kamla Nehru college of pharmacy, Butibori Nagpur 441 108, India
Baheti J. R.
Kamla Nehru college of pharmacy, Butibori Nagpur 441 108, India

Abstract


Montelukastsodium is a selective, orally acting leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis. In addition, patients with asthma need fast and immediate action of drug and avoidance of water is also desirable. Further, chewable tablets are beneficial for patients having difficulty in swallowing. The objective of the present study was to develop chewable tablets containing different compositions of ingredients by using direct compression method. Microcrystalline cellulose, mannitol, magnesium stearate, cross povidone and aspartame were used in the formulation in different concentrations. The prepared tablets were evaluated for various parameters like weight variation, thickness, friability, drug content, and in-vitro drug release. The in-vitro release study of formulation F7 was found to show 98% drug release in 30 minutes and stability studies showed no significant changes.

Keywords


Chewable tablets, Montelukast sodium, Direct compression method, Cross povidone, Stability study

References