Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Formulation and Evaluation of Chewable Tablets of Anti-asthmatic Drug


Affiliations
1 Kamla Nehru college of pharmacy, Butibori Nagpur 441 108, India
     

   Subscribe/Renew Journal


Montelukastsodium is a selective, orally acting leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis. In addition, patients with asthma need fast and immediate action of drug and avoidance of water is also desirable. Further, chewable tablets are beneficial for patients having difficulty in swallowing. The objective of the present study was to develop chewable tablets containing different compositions of ingredients by using direct compression method. Microcrystalline cellulose, mannitol, magnesium stearate, cross povidone and aspartame were used in the formulation in different concentrations. The prepared tablets were evaluated for various parameters like weight variation, thickness, friability, drug content, and in-vitro drug release. The in-vitro release study of formulation F7 was found to show 98% drug release in 30 minutes and stability studies showed no significant changes.

Keywords

Chewable tablets, Montelukast sodium, Direct compression method, Cross povidone, Stability study
Subscription Login to verify subscription
User
Notifications
Font Size


  • Shruthi et al. Preparation and evaluation of Montelukast sodium chewable tablets using modified karaya gum. Der Pharmacia Sinica. 2013; 4(4): 125-135.

  • Kumar PB, Priyanka. Formulation development and evaluation of Montelukast sodium chewable tablets. Journal of Chemical and Pharmaceutical Sciences. 2013; 6(1): 35-40.

  • Janugadeet al. Formulation and evaluation of press-coated Montelukast sodium tablets for pulsatile drug delivery system. International Journal of ChemTech Research. 2009; 1(3): 690-691.

  • Raghavendrarao NG, Kulkarni U. Formulation and design of fast dissolving tablets of Felodipine using novel co-processed superdisintegrants. International Journal of Pharma Research and Development – Online. 2010; 2 (9): 113-121.

  • Rajesh M, Hariharaputhraayyanar G, Venkateshbabu R. Formulation and evaluation of sugar free chewable tablets of Montelukast sodium. International Journal of Pharmaceutical Sciences Review and Research. 2019; 56(1): 6-11.

  • Tripathi KD. Essentials of Medical Pharmacology. Jaypee Brothers Medical Publishers (P) Limited. 2008.

  • Durga NK, Sai B, Prameela A. Chronomodulated drug delivery system of Montelukast sodium. Der Pharmacia Lettre, 2010; 2(5): 316-329.

  • Subhramanyam CVS. Laboratory Manual of Physical Pharmaceutics. Vallabh Prakashan. 1996.

  • Swamivelmanickam M, Venkatesan P, Sangeetha G. Preparation and evaluation of mouth dissolving tablets of Loratadine by direct compression method. Research Journal of Pharmacy and Technology. 2020; 13(6): 1625-1629.

  • ShagneCG. Pharmaceutical Manufacturing Handbook Production and process. 2008.

  • Indian Pharmacopeia, The controller of publication. Ministry of Health and welfare. 1996.

  • Palanichamy et al. Formulation and evaluation of Albendazole fast dissolving tablets. Research Journal of Pharmacy and Technology. 2011; 4(11): 1717-1720.

  • Sahu et al. Formulation and evaluation of orodispersible tablet of Montelukast sodium. Research Journal of Pharmacy and Technology. 2018; 11(3): 1112-1118.

  • Dixit YD, Suruse PB, Shivhare UD. Formulation and evaluation of mucoadhesivebuccal tablet of Domperidone maleate. Indonesian Journal of Pharmacy. 2013; 24(1): 47-55.

  • Kumar K, Chopra H, Sharma G. Formulation and evaluation of fast dissolving tablet of Montelukast by using co-processed excipients. Research Journal of Pharmacy and Technology. 2019; 12(11): 5543-5548.

  • Patil et al. Formulation and in vitro evaluation of floating matrix tablets of Ofloxacin. Asian Journal of Research in Pharmaceutical Sciences. 2011; 1(1): 17-22.

  • Sahu D, Verma S, Dubey R. Formulation and evaluation of Tolperisone hydrochloride sustained release tablet. Research Journal of Pharmaceutical Dosage Forms and Technology. 2011; 3(5): 220-224

  • Shyamaladevi D, Suresh Kumar S. Formulation and evaluation of bilayer tablets of Montelukast sodium immediate release and Doxofylline sustained release. Research Journal of Pharmacy and Technology. 2013; 6(12): 1370-1374.

  • Kengeri et al. Design and characterization of quick dissolving film for simultaneous delivery of Montelukast sodium and Levocetirizinedihydrochloride. Research Journal of Pharmacy and Technology. 2018; 11(5): 1705-1712.

  • Bande et al. Formulation and Evaluation of Instant Palatable Mouth Dissolving Tablets of Diphenhydramine HCl for Allergic Reactions - As Novel Approach. Research Journal of Pharmacy and Technology. 2011; 4(2): 320-325.

  • Jaybhaye A, Joshi S, Deshmukh G. Orodispersible Tablets: A Comprehensive Review. Research Journal of Pharmacy and Technology. 2014; 7(3): 368-375.

  • Kushwaha P. Significance of Stability Studies on Degradation Product. Research Journal of Pharmacy and Technology. 2009; 2(4): 621-627.

  • Narang et al. Formulation design of bilayer dual-release tablet composition of Fexofenadine HCL and Montelukast sodium. Research Journal of Pharmacy and Technology. 2016; 9(9): 1410-1416.


Abstract Views: 155

PDF Views: 0




  • Formulation and Evaluation of Chewable Tablets of Anti-asthmatic Drug

Abstract Views: 155  |  PDF Views: 0

Authors

Suruse P. B
Kamla Nehru college of pharmacy, Butibori Nagpur 441 108, India
Band K. S
Kamla Nehru college of pharmacy, Butibori Nagpur 441 108, India
Ingole A. R
Kamla Nehru college of pharmacy, Butibori Nagpur 441 108, India
Baheti J. R.
Kamla Nehru college of pharmacy, Butibori Nagpur 441 108, India

Abstract


Montelukastsodium is a selective, orally acting leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis. In addition, patients with asthma need fast and immediate action of drug and avoidance of water is also desirable. Further, chewable tablets are beneficial for patients having difficulty in swallowing. The objective of the present study was to develop chewable tablets containing different compositions of ingredients by using direct compression method. Microcrystalline cellulose, mannitol, magnesium stearate, cross povidone and aspartame were used in the formulation in different concentrations. The prepared tablets were evaluated for various parameters like weight variation, thickness, friability, drug content, and in-vitro drug release. The in-vitro release study of formulation F7 was found to show 98% drug release in 30 minutes and stability studies showed no significant changes.

Keywords


Chewable tablets, Montelukast sodium, Direct compression method, Cross povidone, Stability study

References