Research Journal of Pharmacy and Technology

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Screening of Novel Hybrid Combinations of Synthetic Drugs with Plant Extracts for Its in Vitro Antioxidant Activity


Affiliations
1 Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka,, India
2 Department of Pharmacognosy, SET’s College of Pharmacy, Dharwad- 580002, Karnataka,, India
3 SAMI Labs limited, R&D Peenya Industrial Area, Banglore-560058 Karnataka, India
     

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The present experiment was carried out with the aim to screen selected herb-drug for its antioxidant activity in combination and individually. The antioxidant activity of test samples were estimated by 2,2 Diphenyl -1-picryl hydrazyl (DPPH) radical scavenging activity, hydroxyl radical scavenging activity, reducing power assay. All the selected herb-drug combinations have shown significant antioxidant activity in all three antioxidant procedures compared to individual herb or drug sample. Hence, it may be concluded that herb-drug combinations have better antioxidant potential than alone.

Keywords

Tinospora cordifolia, Ocimum sanctum, Terminalia arjuna, Antioxidant activity, Atenolol, Propranolol and Amlodipine.
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  • Screening of Novel Hybrid Combinations of Synthetic Drugs with Plant Extracts for Its in Vitro Antioxidant Activity

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Authors

Chetan Savant
Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka,, India
Venkatrao Kulkarni
Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka,, India
Preeti Kulkarni
Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka,, India
Prasanna Habbu
Department of Pharmacognosy, SET’s College of Pharmacy, Dharwad- 580002, Karnataka,, India
Muhammed Majeed
SAMI Labs limited, R&D Peenya Industrial Area, Banglore-560058 Karnataka, India
Mahadeva Nayak
SAMI Labs limited, R&D Peenya Industrial Area, Banglore-560058 Karnataka, India

Abstract


The present experiment was carried out with the aim to screen selected herb-drug for its antioxidant activity in combination and individually. The antioxidant activity of test samples were estimated by 2,2 Diphenyl -1-picryl hydrazyl (DPPH) radical scavenging activity, hydroxyl radical scavenging activity, reducing power assay. All the selected herb-drug combinations have shown significant antioxidant activity in all three antioxidant procedures compared to individual herb or drug sample. Hence, it may be concluded that herb-drug combinations have better antioxidant potential than alone.

Keywords


Tinospora cordifolia, Ocimum sanctum, Terminalia arjuna, Antioxidant activity, Atenolol, Propranolol and Amlodipine.

References