Research Journal of Pharmacy and Technology

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Parthenium-turmeric Ointment: A Novel Approach for Excision Wound Healing on Rabbits


Affiliations
1 Department of Pharmaceutical Technology, Bengal School of Technology (A College of Pharmacy), Delhi Road, Sugandha, Hoogly, Pin-712102, West Bengal,, India
2 Department of Pharmaceutics, BCDA College of Pharmacy and Technology, 78/1 Jessore Road (S), Hridaypur, Barasat, Kolkata 700127, West Bengal, India
3 Bengal College of Pharmaceutical Sciences and Research, Basu Sarani, Burdwan, Bidhannagar, Durgapur, Pin-713212, West Bengal,, India
4 Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Barasat, Kolkata 700125, West Bengal,, India
     

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Traditional phytomedicines owing to their affordable price and fewer side effects over synthetic preparations may have a wide range of applications in primary health care system. However, there was no scientific report documented so far on the excision wound healing activity of Parthenium hysterophorus-Turmeric ethanolic extract on rabbits. The present study deals with the formulation and evaluation of Parthenium hysterophorus-Turmeric ointment in definite ratio. The four batches were examined for hemocompatibility study and characterised for physical appearance, pH, rheological behaviour, in-vitro drug diffusion pattern, skin irritation excision wound healing and stability study. All the hemocompatible herbal formulations were found to possess satisfactory organoleptic properties and applicability parameters. An inverse relationship was observed between viscosity and % spreadability of ointments. Non-Fickian diffusion based controlled drug release was observed for all these topical preparations. Excision wound healing activity was assessed on the basis of % wound contraction, duration of epithelisation and tensile strength. PHTO1 (ethanolic extract of Parthenium hysterophorus: Turmeric-3:2) showed greater (1.10-1.34 times) wound healing activity compared to only Parthenium extract containing ointment (PHO1). Tissue debride effect was also observed after 7th day of applications of each formulation. All the prepared Parthenium-Turmeric formulations were found to be stable suggesting elaborative research to confirm the pharmacologically active constituent responsible for excision wound healing activity.

Keywords

Epithelisation, Excision wound healing, Non-Fickian diffusion, Parthenium hysterophorus, Tissue debride effect, Wound contraction
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  • Parthenium-turmeric Ointment: A Novel Approach for Excision Wound Healing on Rabbits

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Authors

Ayon Dutta
Department of Pharmaceutical Technology, Bengal School of Technology (A College of Pharmacy), Delhi Road, Sugandha, Hoogly, Pin-712102, West Bengal,, India
Dipanjana Ash
Department of Pharmaceutics, BCDA College of Pharmacy and Technology, 78/1 Jessore Road (S), Hridaypur, Barasat, Kolkata 700127, West Bengal, India
Animesh Roy
Bengal College of Pharmaceutical Sciences and Research, Basu Sarani, Burdwan, Bidhannagar, Durgapur, Pin-713212, West Bengal,, India
Piyali Khamkat
Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Barasat, Kolkata 700125, West Bengal,, India
Abhishek Ghosh
Bengal College of Pharmaceutical Sciences and Research, Basu Sarani, Burdwan, Bidhannagar, Durgapur, Pin-713212, West Bengal,, India

Abstract


Traditional phytomedicines owing to their affordable price and fewer side effects over synthetic preparations may have a wide range of applications in primary health care system. However, there was no scientific report documented so far on the excision wound healing activity of Parthenium hysterophorus-Turmeric ethanolic extract on rabbits. The present study deals with the formulation and evaluation of Parthenium hysterophorus-Turmeric ointment in definite ratio. The four batches were examined for hemocompatibility study and characterised for physical appearance, pH, rheological behaviour, in-vitro drug diffusion pattern, skin irritation excision wound healing and stability study. All the hemocompatible herbal formulations were found to possess satisfactory organoleptic properties and applicability parameters. An inverse relationship was observed between viscosity and % spreadability of ointments. Non-Fickian diffusion based controlled drug release was observed for all these topical preparations. Excision wound healing activity was assessed on the basis of % wound contraction, duration of epithelisation and tensile strength. PHTO1 (ethanolic extract of Parthenium hysterophorus: Turmeric-3:2) showed greater (1.10-1.34 times) wound healing activity compared to only Parthenium extract containing ointment (PHO1). Tissue debride effect was also observed after 7th day of applications of each formulation. All the prepared Parthenium-Turmeric formulations were found to be stable suggesting elaborative research to confirm the pharmacologically active constituent responsible for excision wound healing activity.

Keywords


Epithelisation, Excision wound healing, Non-Fickian diffusion, Parthenium hysterophorus, Tissue debride effect, Wound contraction

References