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Apigenin: Review of Mechanisms of Action as Antimalarial


Affiliations
1 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, West Java,, Indonesia
2 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Jenderal Achmad Yani, West Java,, Indonesia
3 Department of Biomedical Sciences, Parasitology Division, Faculty of Medicine, Universitas Padjadjaran, West Java,, Indonesia
     

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Apigenin is a natural compound that is present in a number of plants such as celery, parsley, grapes, chamomile, onions, maize, tea, sugar, and sprouts belonging to the flavone subclass of flavonoid. Like vitamins, anti-inflammatory medications, vasodilators, anticoagulation, antidiabetes, anticancer, antimalarial drugs, apigenin has many pharmacological functions. The main therapeutic agent for malarial disease is apigenin, based on in vitro, in vivo, and silico research. The purpose of the review is to describe the mechanism of apigenin as an antimalarial agent. Apigenin has antimalarial mechanisms that are confirmed to induce ABCC1 transporters, inhibit protein kinase (Pf RIO-2 kinase) (right open reading frame-2 protein kinase), and act as an antioxidant.

Keywords

Plasmodium falciparum, Flavonoid, Apigenin, Antimalarial, Antioxidant.
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  • Apigenin: Review of Mechanisms of Action as Antimalarial

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Authors

Faizal Hermanto
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, West Java,, Indonesia
Anas Subarnas
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, West Java,, Indonesia
Afifah B. Sutjiatmo
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Jenderal Achmad Yani, West Java,, Indonesia
Afiat Berbudi
Department of Biomedical Sciences, Parasitology Division, Faculty of Medicine, Universitas Padjadjaran, West Java,, Indonesia

Abstract


Apigenin is a natural compound that is present in a number of plants such as celery, parsley, grapes, chamomile, onions, maize, tea, sugar, and sprouts belonging to the flavone subclass of flavonoid. Like vitamins, anti-inflammatory medications, vasodilators, anticoagulation, antidiabetes, anticancer, antimalarial drugs, apigenin has many pharmacological functions. The main therapeutic agent for malarial disease is apigenin, based on in vitro, in vivo, and silico research. The purpose of the review is to describe the mechanism of apigenin as an antimalarial agent. Apigenin has antimalarial mechanisms that are confirmed to induce ABCC1 transporters, inhibit protein kinase (Pf RIO-2 kinase) (right open reading frame-2 protein kinase), and act as an antioxidant.

Keywords


Plasmodium falciparum, Flavonoid, Apigenin, Antimalarial, Antioxidant.

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