Research Journal of Pharmacy and Technology

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Development Characterization and Molecular Simulation Studies Of Metoclopramide Hcl and Tramadol Hcl Bilayer Tablets


Affiliations
1 Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai,, India
2 Department of Pharmaceutics, Raghu college of Pharmacy, Visakhapatnam, AndhraPradesh,, India
3 Department of Pharmaceutical Chemistry, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu,, India
4 Department of Pharmacology, Vignan Pharmacy college, Vadlamudi,Guntur, Andhra Pradesh., India
5 Department of Pharmacognosy, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh,, India
     

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This work mainly aimed to develop bilayer tablets of drug Metoclopramide HCl and Tramadol HCl with the aid of various polymers such as Guar gum, HPMC, Na CMC and Xanthan gum, either alone or in mixtures. Tablets were ready by instant unleash direct compression and sustained release wet granulation methodology and assessed for numerous physical parameters. The drug unleashes studies were performed exploitation USP equipment sort exploitation zero. 1N HCl and pH scale 6.8 phosphate buffers as dissolution medium. Drug unleash was quicker from Metoclopramide layer and tramadol combination with HPMC, Na CMC, Guargum with Xanthan gum it continuous drug unleash efficiently. The fitting the dissolution approach, initial order, Hixson Crowell and Higuchi, Korsmeyer-Peppas equations were used to analyze the speed and unleash mechanism of Tramadol HCl. Results showed that zero-order unleash Mechanism was followed by F1-F10 formulations. The plots (Higuchi) for all the designs remained rectilinear representing the drug unleash by diffusion controlled. Hixon-Crowell root model showed high r2 price proportion because of hydrophobicity of the gel layer erosion. The discharge configuration, consequences of the in-vitro dissolution information stood fitted to the Korsmeyer-Peppas equation that illustrates the delivery mechanism directs the non fickian transport it confers with a combination of each diffusion and erosion rate delivery. The results concluded that the formulation F10 will improve patient compliance in pain and gastro esophageal reflex and also provides higher wellness management.

Keywords

Metoclopramide, Tramadol HCl, Metoclopramide HCl, Bilayer, Molecular simulation.
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  • Development Characterization and Molecular Simulation Studies Of Metoclopramide Hcl and Tramadol Hcl Bilayer Tablets

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Authors

Mohammad Habeeb
Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai,, India
K. L. Deepthi
Department of Pharmaceutics, Raghu college of Pharmacy, Visakhapatnam, AndhraPradesh,, India
M. Vijaya Vara Prasad
Department of Pharmaceutical Chemistry, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu,, India
N. Irfan
Department of Pharmaceutical Chemistry, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu,, India
Shaik Liakhat Ali
Department of Pharmacology, Vignan Pharmacy college, Vadlamudi,Guntur, Andhra Pradesh., India
K. Navyaja
Department of Pharmacognosy, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh,, India

Abstract


This work mainly aimed to develop bilayer tablets of drug Metoclopramide HCl and Tramadol HCl with the aid of various polymers such as Guar gum, HPMC, Na CMC and Xanthan gum, either alone or in mixtures. Tablets were ready by instant unleash direct compression and sustained release wet granulation methodology and assessed for numerous physical parameters. The drug unleashes studies were performed exploitation USP equipment sort exploitation zero. 1N HCl and pH scale 6.8 phosphate buffers as dissolution medium. Drug unleash was quicker from Metoclopramide layer and tramadol combination with HPMC, Na CMC, Guargum with Xanthan gum it continuous drug unleash efficiently. The fitting the dissolution approach, initial order, Hixson Crowell and Higuchi, Korsmeyer-Peppas equations were used to analyze the speed and unleash mechanism of Tramadol HCl. Results showed that zero-order unleash Mechanism was followed by F1-F10 formulations. The plots (Higuchi) for all the designs remained rectilinear representing the drug unleash by diffusion controlled. Hixon-Crowell root model showed high r2 price proportion because of hydrophobicity of the gel layer erosion. The discharge configuration, consequences of the in-vitro dissolution information stood fitted to the Korsmeyer-Peppas equation that illustrates the delivery mechanism directs the non fickian transport it confers with a combination of each diffusion and erosion rate delivery. The results concluded that the formulation F10 will improve patient compliance in pain and gastro esophageal reflex and also provides higher wellness management.

Keywords


Metoclopramide, Tramadol HCl, Metoclopramide HCl, Bilayer, Molecular simulation.

References