Research Journal of Pharmacy and Technology

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Development Characterization and Molecular Simulation Studies Of Metoclopramide Hcl and Tramadol Hcl Bilayer Tablets


Affiliations
1 Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai,, India
2 Department of Pharmaceutics, Raghu college of Pharmacy, Visakhapatnam, AndhraPradesh,, India
3 Department of Pharmaceutical Chemistry, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu,, India
4 Department of Pharmacology, Vignan Pharmacy college, Vadlamudi,Guntur, Andhra Pradesh., India
5 Department of Pharmacognosy, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh,, India
     

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This work mainly aimed to develop bilayer tablets of drug Metoclopramide HCl and Tramadol HCl with the aid of various polymers such as Guar gum, HPMC, Na CMC and Xanthan gum, either alone or in mixtures. Tablets were ready by instant unleash direct compression and sustained release wet granulation methodology and assessed for numerous physical parameters. The drug unleashes studies were performed exploitation USP equipment sort exploitation zero. 1N HCl and pH scale 6.8 phosphate buffers as dissolution medium. Drug unleash was quicker from Metoclopramide layer and tramadol combination with HPMC, Na CMC, Guargum with Xanthan gum it continuous drug unleash efficiently. The fitting the dissolution approach, initial order, Hixson Crowell and Higuchi, Korsmeyer-Peppas equations were used to analyze the speed and unleash mechanism of Tramadol HCl. Results showed that zero-order unleash Mechanism was followed by F1-F10 formulations. The plots (Higuchi) for all the designs remained rectilinear representing the drug unleash by diffusion controlled. Hixon-Crowell root model showed high r2 price proportion because of hydrophobicity of the gel layer erosion. The discharge configuration, consequences of the in-vitro dissolution information stood fitted to the Korsmeyer-Peppas equation that illustrates the delivery mechanism directs the non fickian transport it confers with a combination of each diffusion and erosion rate delivery. The results concluded that the formulation F10 will improve patient compliance in pain and gastro esophageal reflex and also provides higher wellness management.

Keywords

Metoclopramide, Tramadol HCl, Metoclopramide HCl, Bilayer, Molecular simulation.
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  • G. Vasavi, P. Naga Haritha, B. Chandrashekar. Formulation Development and In vitro Evaluation of Transdermal Patches of Tramadol HCl. Asian J. Res. Pharm. Sci. 2018; 8(3):123-129.

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  • Rajesh Shukla, R. Sivakumar, P.R. Vijayanand, P. Kumar Nallasivan, R. Venkatnarayanan. RP-HPLC Method for Simultaneous Estimation of Tramadol HCl and Paracetamol Bulk Drug and Its Combined Dosage Form. Asian J. Research Chem. 3(3): July- Sept. 2010; Page 552-554.

  • Aruna R., Venkateswara Rao T. Design and Development of Bilayer Floating Tablets of Diltiazem Hydrochloride. Research J. Pharma. Dosage Forms and Tech. 2011; 3(6): 304-309.

  • Salma Banu S.K., Venkateswara Rao T. Design and Development of Sustained Release Bilayered Tablets of Glipizide. Research J. Pharma. Dosage Forms and Tech. 2012; 4(1):24-31.

  • Ankarao, CH. Babu Rao, N. Devanna. Formulation and Evaluation of Buccoadhesive Bilayered Tablets of Terbutaline Sulphate. Research J. Pharma. Dosage Forms and Tech. 2012; 4(1):32-35.

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  • Nishanth I., Elango K., Deattu N., Stephen P. Formulation Development and Evaluation of Bilayer Tablets of Telmisartan for Immediate Release and Metformin Hydrochloride for Sustained Release. Research J. Pharma. Dosage Forms and Tech. 2013; 5(3): 139-144.

  • Mukund G Tawar , Pawar M D, P D Chaudhari. Development and Evaluation of Tramadol Hydrochloride Sustained Release Tablet. Research J. Pharm. and Tech. 2 (3): July-Sept. 2009; Page 470-473.

  • R.Z. Mujoriya, Venkateshvarlu, D.C. Singh, V.A. Gupta, A Bisen, A.B. Bondre. Formulation Development and Evaluation of Metoprolol Succinate ER and Amlodipine Besilate Bilayer Tablet. Research J. Pharm. and Tech. 3 (4): Oct.-Dec.2010; Page 1291-1294.

  • Reddy KR, Mutalik S, Reddy S. Once-daily sustained-release matrix tablets of nicorandil: formulation and in vitro evaluation. AAPS Pharm SciTech. 2003; 4: 1-9.

  • Shiyani B, Gattani S, Surana S. Formulation and evaluation of bilayer tablet of metoclopramide hydrochloride and ibuprofen. AAPS Pharm Sci Tech. 9: 818-827.

  • Pranjal Kumar S, Sanjoo Kumar D, VK Shukla, Guru Sharan P, Pankaj Verma K, and Samiran D. Bilayer and Floating-Bioadhesive tablets: Innovative approach to Gastro retention. Journal of Drug Delivery and Therapeutics. 2011; 1(1): 32-35.

  • Hiten Ashok P, Ajay Kumar T. A Novel approach of Bilayer Tablet technology: A Review. International Research Journal of Pharmacy. 2012; 5-10.

  • Manidipta D. Bilayer Tableting Technology: An Overview. Journal of Pharmacy Research. 2012; 25(1): 310-314.

  • Mohit Solakhia T, Ashish Kumar K, Dr.Shikha Agrawal D, and Dishant G. Bi-Layer Tablets: An Emerging Trend. International Journal of Pharmaceutical and Biological Archives. 2012; 3(3): 499-506.

  • Shivakumar HN, Nath BS, Desai BG. Effect of added HPMC and HEC on the release of cetostearyl alcohol embedded diclofenac sodium from tables for controlled release. The Eastern Pharmacist. 2001: 117-9.

  • Hosseinali T, Seyed AM, Tina BG. Preparation of sustained release matrix tablets of aspirin with ethylcellulose, Eudragit RS100 and eudragit S100 and studying the release profile and their sensitivity to Tablets hardness. Iranian Journal of Pharm Research. 2003: 201-06.

  • Kale VV, Kaslival RH, Avari JG. Effect of matrix geometry on drug release from guar gum matrix Tablets. Indian Drugs. 2005; 42: 84-6.

  • Haider SS, Monnujan N, Shahriyar SM. Sustained release preparation of metoclopramide hydrochloride based on fatty matrix. Indian Drugs. 2002; 39:73-9.

  • C. Pessina. Metabolic effects and safety profile of nebivolol. Journal of Cardiovascular Pharmacology. Vol. 38, 2002; no. 3, pp. S33– S35,

  • J. R. Patel, B. A. Patel, D. G. Patel, D. S. Patel, and V. B. Patel. Formulation and evaluation of oral controlled drug delivery system for a model anti diabetic drug metformin. International Journal of Current Pharmaceutical Research. Vol. 3, 2011; pp. 37–39,

  • M. Rangapriya, V. Manigandan, R. Natarajan, and K. Mohan Kumar. Formulation and evaluation of floating tablets of Pioglitazone hydrochloride. International Journal of Pharmaceutical and Chemical Sciences. Vol. 1, 2012; pp. 1048–1054,

  • V. Thanda, S. Firoz, C. Yerram, A. Vikram, S. K. Divya, and K. T. Murali. Design and characterization sustained release matrix tablets of Repaglinide using natural polymers. International Journal of Pharmacy. Vol. 2, 2012; pp. 73–83,

  • D. Vamshi, P. Laxmi Madhuri, and G. Tuljarani. Method development and validation of indapamide and nebivolol hydrochloride by rp-HPLC method. International Journal of Research in Pharmaceutical and Nano Sciences. Vol. 2, 2013; No. 6, pp. 798–810,

  • G. H. Kumar, K. Jaganathan, R. S. Kumar, and P. Peruma. Formulation and in-vitro evaluation of bilayer floating tablets of Metformin hydrochloride and Sitagliptin phosphate. International Journal of Advanced Pharmaceutics. Vol. 2, 2012; no. 2, pp. 64–81,

  • D. Rohini, S. Alexandar, and M. J. N. Chandrasekar. Preparation and in vitro evaluation of sustained release tablet formulations of metformin HCl. Asian Journal of Pharmaceutical and Clinical Research. Vol. 5, no. 1, pp. 2012; 45–48,

  • K. Venkateswarlu and A. Shanthi. Formulation and evaluation of sustained release glipizide matrix,. IOSR Journal of Pharmacy and Biological Sciences (IOSRJPBS), Vol. 2, 2012; no. 5, pp. 17–23,

  • P. Shirse. Formulation and evaluation of bilayered tablets of HP-𝛽-cyclodextrin complex glimepiride with metformin hydrochloride for immediate and sustain release. International Journal of Pharmacy and Biological Sciences, Vol. 3, 2012; no. 3, pp. 148–160,


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  • Development Characterization and Molecular Simulation Studies Of Metoclopramide Hcl and Tramadol Hcl Bilayer Tablets

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Authors

Mohammad Habeeb
Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai,, India
K. L. Deepthi
Department of Pharmaceutics, Raghu college of Pharmacy, Visakhapatnam, AndhraPradesh,, India
M. Vijaya Vara Prasad
Department of Pharmaceutical Chemistry, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu,, India
N. Irfan
Department of Pharmaceutical Chemistry, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu,, India
Shaik Liakhat Ali
Department of Pharmacology, Vignan Pharmacy college, Vadlamudi,Guntur, Andhra Pradesh., India
K. Navyaja
Department of Pharmacognosy, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh,, India

Abstract


This work mainly aimed to develop bilayer tablets of drug Metoclopramide HCl and Tramadol HCl with the aid of various polymers such as Guar gum, HPMC, Na CMC and Xanthan gum, either alone or in mixtures. Tablets were ready by instant unleash direct compression and sustained release wet granulation methodology and assessed for numerous physical parameters. The drug unleashes studies were performed exploitation USP equipment sort exploitation zero. 1N HCl and pH scale 6.8 phosphate buffers as dissolution medium. Drug unleash was quicker from Metoclopramide layer and tramadol combination with HPMC, Na CMC, Guargum with Xanthan gum it continuous drug unleash efficiently. The fitting the dissolution approach, initial order, Hixson Crowell and Higuchi, Korsmeyer-Peppas equations were used to analyze the speed and unleash mechanism of Tramadol HCl. Results showed that zero-order unleash Mechanism was followed by F1-F10 formulations. The plots (Higuchi) for all the designs remained rectilinear representing the drug unleash by diffusion controlled. Hixon-Crowell root model showed high r2 price proportion because of hydrophobicity of the gel layer erosion. The discharge configuration, consequences of the in-vitro dissolution information stood fitted to the Korsmeyer-Peppas equation that illustrates the delivery mechanism directs the non fickian transport it confers with a combination of each diffusion and erosion rate delivery. The results concluded that the formulation F10 will improve patient compliance in pain and gastro esophageal reflex and also provides higher wellness management.

Keywords


Metoclopramide, Tramadol HCl, Metoclopramide HCl, Bilayer, Molecular simulation.

References