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Efficacy of Nanocurcumin with Application of Iontophoresis On Inflammatory Arthritis Patients.


Affiliations
1 Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
2 Professor, Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
     

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Background: Rheumatoid arthritis (RA) is a chronic inflammatory systemic disorder that primarily affects smaller joints characterized by periods of severe pain, stiffness, and swelling and destruction of the bones and cartilage. As indicated by past investigations, oral organization of curcumin results in calming impact regardless of its low bioavailability in patients. Objective: This study aims to measure the efficacy of nanocurcumin particles with iontophoresis in inflammatory arthritis patients. Methodology: Nanocurcumin were prepared by a process based on a wet-milling technique. In vitro anti inflammatory assay of nanocurcumin was determined by Bradford assay using bovine serum albumin (BSA) as the standard. The prospective study was done among a 10 patients from the reports obtained from March 2020 to October 2020 in Physiotherapy clinic, Madurai. Results: All the curcumin-treated groups showed significant alleviation of inflammatory arthritic condition (p<0.05) when compared with inflammatory arthritic controls. Conclusion: Iontophoretic administration of curcumin may ameliorate arthritic symptoms significantly, and the effect is assumed to be due to better penetration and enhanced bioavailability. Geriatrics patients are supposed to be benefited fairly by this technique.


Keywords

Iontophoresis, Curcumin, Nanosize, Inflammation, Arthritis.
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  • Efficacy of Nanocurcumin with Application of Iontophoresis On Inflammatory Arthritis Patients.

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Authors

Nivetha. B
Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
Rahmathunisha. A
Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
Lokeshwari. K
Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
Kumaresan. A
Professor, Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
Sai Nikkitha. K.V
Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
Yeseshivi. L
Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
Janani. R
Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India

Abstract


Background: Rheumatoid arthritis (RA) is a chronic inflammatory systemic disorder that primarily affects smaller joints characterized by periods of severe pain, stiffness, and swelling and destruction of the bones and cartilage. As indicated by past investigations, oral organization of curcumin results in calming impact regardless of its low bioavailability in patients. Objective: This study aims to measure the efficacy of nanocurcumin particles with iontophoresis in inflammatory arthritis patients. Methodology: Nanocurcumin were prepared by a process based on a wet-milling technique. In vitro anti inflammatory assay of nanocurcumin was determined by Bradford assay using bovine serum albumin (BSA) as the standard. The prospective study was done among a 10 patients from the reports obtained from March 2020 to October 2020 in Physiotherapy clinic, Madurai. Results: All the curcumin-treated groups showed significant alleviation of inflammatory arthritic condition (p<0.05) when compared with inflammatory arthritic controls. Conclusion: Iontophoretic administration of curcumin may ameliorate arthritic symptoms significantly, and the effect is assumed to be due to better penetration and enhanced bioavailability. Geriatrics patients are supposed to be benefited fairly by this technique.


Keywords


Iontophoresis, Curcumin, Nanosize, Inflammation, Arthritis.

References