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Efficacy of Nanocurcumin with Application of Iontophoresis On Inflammatory Arthritis Patients.


Affiliations
1 Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
2 Professor, Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
     

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Background: Rheumatoid arthritis (RA) is a chronic inflammatory systemic disorder that primarily affects smaller joints characterized by periods of severe pain, stiffness, and swelling and destruction of the bones and cartilage. As indicated by past investigations, oral organization of curcumin results in calming impact regardless of its low bioavailability in patients. Objective: This study aims to measure the efficacy of nanocurcumin particles with iontophoresis in inflammatory arthritis patients. Methodology: Nanocurcumin were prepared by a process based on a wet-milling technique. In vitro anti inflammatory assay of nanocurcumin was determined by Bradford assay using bovine serum albumin (BSA) as the standard. The prospective study was done among a 10 patients from the reports obtained from March 2020 to October 2020 in Physiotherapy clinic, Madurai. Results: All the curcumin-treated groups showed significant alleviation of inflammatory arthritic condition (p<0.05) when compared with inflammatory arthritic controls. Conclusion: Iontophoretic administration of curcumin may ameliorate arthritic symptoms significantly, and the effect is assumed to be due to better penetration and enhanced bioavailability. Geriatrics patients are supposed to be benefited fairly by this technique.


Keywords

Iontophoresis, Curcumin, Nanosize, Inflammation, Arthritis.
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  • F. Cavaleri, “Presenting a new standard drug model for turmeric and its prized extract, curcumin,” International Journal of Inflammation, vol. 2018, Article ID 5023429, pages, 2018, 118- 132

  • Anubhav Das, Anitha Roy, S. Rajeshkumar, T. Lakshmi. Antiinflammatory Activity of Turmeric Oil Mediated Silver Nanoparticles. Research J. Pharm. and Tech. 2019; 12(7):3507- 3510.

  • Nirisha Sriram, Gheena. S, Samrithi Yuvaraj. Effects of turmeric on oral submucous fibrosis: A Systematic Review. Research J. Pharm. and Tech. 2015; 8(8):1051-1055.

  • Suman Saha, Amit Roy, Sanjib Bahadur, Ananta Choudhury. Bioenhamcement of Curcumin by Dual approach. Research J. Pharm. and Tech. 2016; 9(8):1059-1063.

  • MD Wandhare, UA Deokate, SS Khadabadi, SP Hadke, HA Sawarkar. Comparative Estimation of Curcumin Content from Marketed Herbal Anti Rheumatic Tablets Formulation. Asian J. Research Chem. 2009; 2(3): 340-343.

  • Ruchika Sharma, Neha Kumari, M.S Ashawat, C.P.S Verma. Standardization and Phytochemical Screening analysis for Herbal Extracts: Zingiber officinalis, Rosc., Curcuma longa Linn., Cinnamonum zeylanicum Nees., Piper longum, Linn., Boerhaavia diffussa Linn. Asian J. Pharm. Tech. 2020; 10(3):127-133.

  • Sweetha G., Sangeetha B., Prabhu S.. A Review on Curcumin Nanoparticles and Its Controlled Delivery to Treat Degenerative Diseases. Asian J. Pharm. Tech. 2013; Vol. 3: Issue 4, Pg 218- 222.

  • Sabale Prafulla, Potey Lata, Rahangdale Priya, Sabale Vidya. Novel Curcumin Derivatives: Targeted for Anti-Inflammatory Activity. Asian J. Research Chem. 2019; 12(2):49-54.

  • LatheeshjlalL, Sunil Murala, Vaidya Mehul J, G Swetha, Phanitejaswini Swapna. Bioavailability Enhancement of Curcumin through Mucoadhesive Drug Delivery System. Research J. Pharm. and Tech. 2011; 4(3): 457-460.

  • Liu, H. Lou, L. Zhao, and P. Fan, “Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipid complex of curcumin,” Journal of Pharmaceutical and Biomedical Analysis, 2006; 40(3): 720–72.

  • S. Blaise, M. Roustit, C. Millet, C. Ribuot, J. Boutonnat, and J. Cracowski, “Cathodal iontophoresis of treprostinil and iloprost induces a sustained increase in cutaneous flux in rats,” British Journal of Pharmacology. 2011; 162(3): 557–565,.

  • Mukund Nagarnaik, Arun Sarjoshi, Ajay Bodkhe, Bhupendra Khanal, Mayuri Pise, Girish Pandya. Characterization of active constituents in Turmeric powder and validation of method for curcumin in samples. Asian J. Research Chem. 2015; 8(10): 643- 64

  • P. Venugopalan, T. V. Deepthi. Chemical and Pharmacological Studies on Curcuminoids. Asian J. Research Chem. 2014; 7(3): 355-365.


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  • Efficacy of Nanocurcumin with Application of Iontophoresis On Inflammatory Arthritis Patients.

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Authors

Nivetha. B
Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
Rahmathunisha. A
Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
Lokeshwari. K
Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
Kumaresan. A
Professor, Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
Sai Nikkitha. K.V
Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
Yeseshivi. L
Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India
Janani. R
Department of Physiotherapy, Saveetha college of Physiotherapy, Chennai – 602105., India

Abstract


Background: Rheumatoid arthritis (RA) is a chronic inflammatory systemic disorder that primarily affects smaller joints characterized by periods of severe pain, stiffness, and swelling and destruction of the bones and cartilage. As indicated by past investigations, oral organization of curcumin results in calming impact regardless of its low bioavailability in patients. Objective: This study aims to measure the efficacy of nanocurcumin particles with iontophoresis in inflammatory arthritis patients. Methodology: Nanocurcumin were prepared by a process based on a wet-milling technique. In vitro anti inflammatory assay of nanocurcumin was determined by Bradford assay using bovine serum albumin (BSA) as the standard. The prospective study was done among a 10 patients from the reports obtained from March 2020 to October 2020 in Physiotherapy clinic, Madurai. Results: All the curcumin-treated groups showed significant alleviation of inflammatory arthritic condition (p<0.05) when compared with inflammatory arthritic controls. Conclusion: Iontophoretic administration of curcumin may ameliorate arthritic symptoms significantly, and the effect is assumed to be due to better penetration and enhanced bioavailability. Geriatrics patients are supposed to be benefited fairly by this technique.


Keywords


Iontophoresis, Curcumin, Nanosize, Inflammation, Arthritis.

References