Open Access
Subscription Access
Open Access
Subscription Access
Formulation and Evaluation of Expectorant Activity of Poly Herbal Cough Syrup from Traditional Medicinal Plant Extracts of North East India
Subscribe/Renew Journal
Poly Herbal formulation composed of multi components which produce synergistic effect apart from boost up of body natural immunity. Plants material may contains polysaccharide, mucilage and tannin which are responsible for the synergism of “active principles”. The Poly herbal cough syrup was prepared by mixing of extracts from five different plants namely Ocimum sanctum, Adhatoda vasica, Cinnamomum verum, Cardamomum subulatum and Ephedra sinica in a syrupy base. The evaluation of the formulation was done by determining different physical parameters such as pH, surface tension, total solid content, specific gravity, viscosity, refractive index and expectorant activity of the cough preparation was done on phenol red induced mice model. The pH, surface tension, total solid content, specific gravity, viscosity and refractive index were found to be 4.82, 54.32 dynes/cm, 38.20% w/v, 1.324 (at 250C), 4.68cp and 1.43 respectively. There was a significant increase (P<0.001) in expectorant activity of the formulation at the doses of 300mg/kg and 600mg/kg as compared to the control group. So the herbal formulation could be used to alleviate mucous secretion from bronchial tract.
Keywords
- Macklin CC. The musculature of the bronchi and lungs. Physiological Reviews. 1929 Jan 1;9(1):1-60.
- Ravindra Singh, Aakanksha Tiwari. Adhatoda vasica: A Miracle and Boon for Asthmatic people - A Review. Res. J. Pharmacognosy and Phytochem. 2016; 8(4): 242-244.
- Thirumagal, M. Deivanayaki. Effect of different Adhatoda vasica leaves media on the growth and cocoon production of Eudrilus eugeniae. Research J. Science and Tech. 2017; 9(2): 288-292.
- Bincy Raj, Salma Khanam, Soosamma John, Madhavi T, Ayesha Siddique. Quantitative Estimation of Rosmarinic Acid in Ocimum sanctum Extracts and Polyherbal Formulation by HPTLC. Research J. Pharmacognosy and Phytochemistry 2010; 2(1): 46-48.
- R. Chandrasekar, B. Sivagami. Formulation and Evaluation of a Poly Herbal Skin Care Cream containing Neem and Tulsi. Research J. Topical and Cosmetic Sci. 9(1): Jan.-June 2018 page 25-32.
- Sankaradoss Nirmala, P Nadana Sabapathi, M Sudhakar, Naveen Bathula, Y Sravanthi. Investigation of In-vitro Anti-cancer property of Adhatoda vasica in Hela, HepG2, MCF-7, MDAMB-231 Cell Lines. Res. J. Pharmacognosy and Phytochem. 2019; 11(4):212-216.
- Ankush Sharma, Bharat Prasar. Formulation and Evaluation of herbal cosmetic cream to produce multipurpose effect on skin. Res. J. Topical and Cosmetic Sci. 4(1): Jan. –June 2013 page 1-4.
- Gairola S, Gupta V, Bansal P, Singh R, Maithani M. Herbal Antitussives and Expectorants – a Review. Int. J. Pharma. Sci. Review and Res. 2010; 5(2): 5-9.
- Hanumanthachar Joshi, Milind Parle. Effects of Memorhis, a Poly Herbal Formulation in the Management memory Dysfunctions. Research J. Pharmacognosy and Phytochemistry 2012; 4(2): 97-103.
- Ali K, Maedeh M and Mahmoud R K. Herbal versus synthetic drugs- beliefs and facts. J Nephropharmacol 2015; 4(1): 27–30.
- M K Khosla. Sacred Tulsi (Ocimum sanctum L.) in Traditional Medicine and Pharmacology. Ancient Science of Life. 1995; 15(1): 53-61.
- Kunii D. & Levenspiel O. Fludization Engineering, John Wiley & Sons N Y, 1991; pp. 24-25.
- Evans W C. Trease and Evans- Pharmacognosy, WB Saunders N Y.2002; 15th ed: pp. 516-520.
- Anonymus. Pharmacopoeia of India. The Controller of Publications New Delhi.1996; Vol 2: pp. A47- A54.
- Nisha Raj R S and Radhamany P M. Pharmacognostic and physicochemical analysis on the leaves of Brunfelsia americana L. Asian Pac J Trop Biomed. 2012; S305-S307.
- Kumar, Promod S and Nayak D P. Development and evaluation of poly herbal syrup from some herbs used as expectorant. W J Pharm and Pharma Sci. 2(5); 2013: 3449.
- Hossain M T and Hoq M O. Therapeutic use of Adhatoda vasica. Asian J Med Biol Res. 2016; 2 (2):156-163.
- Ashokkumar K, Murugan M, Dhanya M K, Warkentin TD. Botany, traditional uses, phytochemistry and biological activities of cardamom [Elettaria cardamomum (L.) Maton] - A critical review. J Ethnopharmacol. 2020;246:112244.
- Aziz A, Khan IA, Afzal A, Munawar SH. Formulation and evaluation of herbal Antitussive syrup of methanolic extract of Lycopus europaeus in mice. American journal of Phamacy & Health Research. 2013;1:121-8.
- OECD. OECD Guideline for Testing of Chemicals. Acute Oral Toxicity—Acute Toxic Class Method.
- Sengottuvelu S, Srinivasan D, Ramasamy S. Toxicological Evaluation of a Novel Anti-Ulcer Herbal Formulation. Res. J. Pharm Tech. 2008;1(3):207-10.
- Ge Y, Zhang F, Qin Q, Shang Y, Wan D. In Vivo Evaluation of the Antiasthmatic, Antitussive, and Expectorant Activities and Chemical Components of Three Elaeagnus Leaves. Evid Based Complement Alternat Med. 2015; 2015: 1-8.
- Meher A. Antitussive evaluation of formulated polyherbal cough syrup. J. Drug Deliv Therap. 2012 Sep 15;2(5).
- Kokati Vankata Bhaskara Rao, Minki Munjal, Amie Patnayak, Loganathan Karthik, Gaurav Kumar. Phytochemical Composition, Antioxidant, Antimicrobial and Cytotoxic Potential of Methanolic Extracts of Adhatoda vasica (Acanthaceae). Res J. Pharm. and Tech. 6(9): September 2013; Page 1004-1009.
Abstract Views: 176
PDF Views: 0