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Modification of the Vancouver Scar Scale (Vss) Score for Scarring Assessment Using Rattus Novergicus Abnormal Scar Model


Affiliations
1 Doctoral Program, Faculty of Medicine, Brawijaya University, Malang 65145,, Indonesia
2 Pharmacology Department, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia
3 Clinical Pathology Departement, Faculty of Medicine, Brawijaya University, Malang 65145,, Indonesia
4 Faculty of Medicine and Health Sciences, State Islamic University of Malang, Malang 65144, Indonesia
     

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The abnormal scar is a unique fibrosis disease because it only occurs in humans (Homo sapiens). Researchers now challenge no other animal species, including primates, are found to naturally form scar7, whereas animal models are essential references for human treatment modalities. This study aimed to determine the Modified Vancouver Scar Scale (VSS) score with the addition of collagen density parameters used to assess the scar in experimental animals quantitatively and generates a better assessment of the scar. The cross-sectional analytical survey method was adopted. The experimental animal was Rattus novergicus. The Modified VSS score was applied to assess the normal and abnormal scar data. The Likert categorization guidelines were used to obtain the VSS Score modification score. The collagen density and VSS had a significantly different based on T-test (p <0.05). The differences were also shown by the control and treatment groups. On the correlation analysis, there were the positive coefficient (0.722). The result can be described that the collagen density increases, when the VSS score is high. It also showed the differences based on the score (p <0.05). The Modified VSS score calculation's final results are classified into three groups namely Good (ranged from 0 to 1); Medium (ranged from 2 to 4); and Adverse (ranged from 5 to 6). The Modified VSS score is possibly to be used for the scar assessment to the Rattus novergicus abnormal scar model.


Keywords

Abnormal scar, Collagen density, Rattus novergicus, VSS score.
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  • Modification of the Vancouver Scar Scale (Vss) Score for Scarring Assessment Using Rattus Novergicus Abnormal Scar Model

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Authors

Herman Y. L. Wihastyoko
Doctoral Program, Faculty of Medicine, Brawijaya University, Malang 65145,, Indonesia
Setyawati Soeharto
Pharmacology Department, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia
Edi Widjajanto
Clinical Pathology Departement, Faculty of Medicine, Brawijaya University, Malang 65145,, Indonesia
Kusworini Handono
Clinical Pathology Departement, Faculty of Medicine, Brawijaya University, Malang 65145,, Indonesia
Bambang Pardjianto
Faculty of Medicine and Health Sciences, State Islamic University of Malang, Malang 65144, Indonesia

Abstract


The abnormal scar is a unique fibrosis disease because it only occurs in humans (Homo sapiens). Researchers now challenge no other animal species, including primates, are found to naturally form scar7, whereas animal models are essential references for human treatment modalities. This study aimed to determine the Modified Vancouver Scar Scale (VSS) score with the addition of collagen density parameters used to assess the scar in experimental animals quantitatively and generates a better assessment of the scar. The cross-sectional analytical survey method was adopted. The experimental animal was Rattus novergicus. The Modified VSS score was applied to assess the normal and abnormal scar data. The Likert categorization guidelines were used to obtain the VSS Score modification score. The collagen density and VSS had a significantly different based on T-test (p <0.05). The differences were also shown by the control and treatment groups. On the correlation analysis, there were the positive coefficient (0.722). The result can be described that the collagen density increases, when the VSS score is high. It also showed the differences based on the score (p <0.05). The Modified VSS score calculation's final results are classified into three groups namely Good (ranged from 0 to 1); Medium (ranged from 2 to 4); and Adverse (ranged from 5 to 6). The Modified VSS score is possibly to be used for the scar assessment to the Rattus novergicus abnormal scar model.


Keywords


Abnormal scar, Collagen density, Rattus novergicus, VSS score.

References