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Background and Objectives: Chronic Obstructive Pulmonary Disease (COPD) is an important cause of disability and death globally and scenario has been infact worsened. Acute exacerbation of COPD (AECOPD) is associated with airway inflammation resulting in increased air trapping, further obstruction of airways and deterioration of gas diffusion. Objectives: The objective of this study is to find out the bacteriological profile and their antibiogram in AECOPD and to study the clinical presentation of AECOPD patients. Materials and Methods: This is a cross sectional study comprising of 45 patients diagnosed with AECOPD. Before starting on antibiotics all patients sputum was sent for culture and sensitivity. All patients were instructed to collect early morning, deep coughed sputum into a sterile sputum container (preferably two). Results: The present study reveals that total 45 cases, 89% were males and 11% were females. The most common organisms isolated were gram negative bacilli (71%) and gram positive bacilli (29%). Pseudomonas aueroginosa was the commonest bacteria isolated (26.7%) followed by streptococcus pneumonia (22.2%), Klebsiella pneumoniae (20%). The drug sensitivity testing revealed that Ciprofloxacin with amikacin is the best empirical antibiotic followed by Cephalosporin with amikacin. Conclusion: AECOPD is more common in adult males above the age of fifty five years secondary to smoking practices. As an empirical therapy in AECOPD patients the best choice of antibiotic therapy would be Ciprofloxacin with amikacin. Other best monotherapy antibiotic would be piperacillin with tazobactam or cefoperazone with sulbactum

Keywords

AECOPD-Acute Exacerbation of Copd.
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