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Sweeteners: From Ancient to Modern Times


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Honey was the first sweetener to be discovered by humans in the ancient times. It remained the main sweetener in Europe until Alexander the Great’s visit to India in 326 BCE, when he came across the sweet-juice-producing sugarcane. Sugarcane originated in India during the Vedic period (1200–1000 BCE), and even today, most of the sugarcane grown all over the world has some genetic linkage to the ‘Noble’ canes bred at the Sugarcane Breeding Institute of the Indian Council of Agricultural Research (ICAR-SBI), India. The technology for making sugar from sugarcane juice was also first developed in India. The word sugar, as well as Saccharum, the generic name for sugarcane, are derived from the Sanskrit word sharkara. Sugar beet as a source of sugar was identified in Europe in the middle of the 18th century. Production of sugar syrups started much later. In recent times, the excess consumption of sugar and modern sedentary lifestyles created the problem of diabetes, triggering the search for non-sugar sweeteners. Saccharin, the world’s first and widely used artificial sweetener was accidentally discovered in 1879 in Germany. It was followed by the discovery of other artificial sweeteners, such asaspartame (APM), cyclamate, sucralose, acesulfame-k and neotame, which have been approved by different government authorities and are being marketed in many countries. Nevertheless, when taken in amounts more than the medically approved levels, they may cause health problems. This has made man turn back to Nature once again and search for natural non-sugar sweeteners. The most acceptable natural non-sugar sweetener today is ‘Stevia’, which had been known to people in South America since ages. Stevia is gaining popularity all over the world, and is reported to have antioxidant, antiviral, anti-hypertension, and anti-inflammatory properties. The two alcohol sweeteners erythritol and xylitol can also be considered as natural, since they are produced from natural products. Erythritol is produced from fermented fruits and foods, while xylitol is produced from hemicelluloses from hardwood. Yet another natural sweetener, licorice (mulethi), is mostly used as a flavoring agent and for medicinal purposes. Licorice, aspartame and cyclamate have nearly the same calorie value as sucrose, while xylitol has 63% calorie value as compared with sucrose. The rest of the non-sugar sweeteners are calorie-free.

Keywords

Acesulfame-k, Aspartame, Cyclamate, Diabetes, Honey, Licorice, Neotame, Saccharine, Stevia, Sucralose, Sucrose, Sugarcane, Sugar Beet.
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  • Acharya B. Ayurveda: Its Principles and Philosophies. New Delhi, India: Divya Prakashan; 2006. p. 206.

  • Adas M (ed.). Agricultural and pastoral societies in ancient and classical history. Philadelphia, USA: Temple University Press; 2001. PMCid:PMC33189

  • Anonymous. The inventor of saccharine. Scientific American, New series. 1886; 60(3): 36.

  • Assirey E. Nutritional components of fruit of 10 date palm (Phoenix dactylifera L.) cultivars grown in Saudi Arabia. Journal of Taibah University of Science. 2015; 9:75–9. https://doi.org/10.1016/j.jtusci.2014.07.002

  • Audreith LF and Sveda M. Preparation and properties of some N-substituted sulphamic acids. Journal of Organic Chemistry. 1944; 9: 89–101. https://doi.org/10.1021/jo01183a011

  • Basu CN. Sugarcane. 2nd Edition. New Delhi, India: Allied Publishers Ltd.; 1990.

  • Bayton RP. A review of Borassus L (Aracaceae). Kew Bulletin. 2007; 62: 561–86.

  • Bender B. Farming in pre-history: from hunter-gatherer to food production. London, UK: Billing and Sons; 1975. p. 68.

  • Bhatt S. Why Indian farmers are struggling to ensure stevia becomes a product of the masses. The Economic Times. 2018 February 8.

  • Boonkaewwan C, Toskulkao C and Vongsakul MJ. Anti-inflammatory and immune modulatory activities of stevioside and its metabolite steviol on THP-1 cells. Journal of Agriculture and Food Chemistry. 2006; 54: 785–9. https://doi.org/10.1021/jf0523465 PMid:16448183

  • Britzer M. Production of sweet sorghum for syrup in Kentucky. Cooperative Extension Service, College of Agriculture, University of Kentucky; Lexington, KY, USA; 2002.

  • Butchko HH, Stargel WW, Comer CP, Mayhew DA, Benninger C, Blackburn GL, et al. Aspartame: review of safety. Regulatory Toxicology and Pharmacology. 2002; 35(2 Pt 2): S1–93. https://doi.org/10.1006/rtph.2002.1542 PMid:12180494

  • Cardello HMAB, Da Silva MAPA, and Damasio MH. Measurement of the relative sweetness of stevia extract, aspartame and cyclamate/saccharin blend as compared to sucrose at different concentrations. Plant Foods for Human Nutrition. 1999; 54(2): 119–29. https://doi.org/10.1023/A:1008134420339

  • Carlson RD. The honey bee and apian imagery in classical literature. Ph.D. Dissertation, University of Wisconsin; Madison, WI, USA; 2015.

  • Chan P, Xu D, Liu J, Chen Y, Tomlinson B, Huang W, and Cheng J. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sciences. 1998; 63: 1679–84. https://doi.org/10.1016/S0024-3205(98)00439-1

  • Chaplin M and Bucks C. Enzyme Technology. Cambridge, UK: Cambridge University Press; 1990.

  • Chattopadhyay S, Raychaudhuri U and Chakraborty R. Artificial sweeteners - a review. Journal of Food Science and Technology. 2014; 51(4): 611–21. https://doi.org/10.1007/s13197-011-0571-1 PMid:24741154 PMCid:PMC3982014

  • Ciesla WM. Non-wood Forest Products from Temperate Broad-leaved Trees. Food and Agriculture Organization of the United Nations (FAO); Rome, Italy; 2002.

  • Clauss K and Jensen H. Oxathiazinone Dioxides - "A New Group of Sweetening Agents". Angewandte Chemie - International Edition. 1973; 12(11): 869–76. https://doi.org/10.1002/anie.197308691

  • Cohen MN. Introduction: rethinking the origin of agriculture. Current Anthropology. 2009; 50(5): 591–5. https://doi.org/10.1086/603548 PMid:20642143

  • Converti A, Parego P and Dominguez JM. Xylitol Production from Hardwood Hemicellulose Hydrosylates. Applied Biochemistry and Biotechnology. 1999; 82: 141–51. https://doi.org/10.1385/ABAB:82:2:141

  • Crane E. The archaeology of beekeeping. Cornell University Press; Ithaca, New York, USA; 1983.

  • Daniels J and Daniels CA. Geographical, historical and cultural aspects of the origin of the Indian and Chinese sugarcanes S. barberi and S. sinense. Sugarcane Breeding Newsletters. 1975; 36: 4–23.

  • Day JL, Duncan RR, Raymer PL, Lovell GR, Thompson DS, Garett HD and Zummo N. Top 76-6: a new sweet sorghum variety for syrup production. The Georgia Agricultural Experiment Station, University of Georgia Griffin; GA, USA. Research Report No. 634; 1995.

  • de Cock P, Makinen K, Honkala E, Saag M, Kennepohl E and Eapen A. Erythritol is More Effective Than Xylitol and Sorbitol in Managing Oral Health Endpoints. International Journal of Dentistry. 2016; 9868421. Published online 21 August 2016. https://doi.org/10.1155/2016/9868421

  • Dowling RN. Sugar beet and beet sugar. London, UK: Ernest Benn Limited; 1928.

  • Eagleson J and Hasner R. The Maple Syrup Book. Erin, Ontario, Canada: The Boston Mills Press; 2006.

  • Eteraf-Oskonei T and Najafi M. Traditional and modern uses of natural honey in human diseases: A Review. Iranian Journal of Basic Medical Sciences. 2013; 16(6): 731–42.

  • Fahlberg Cand Remsen I. Uber die oxydation des orthotoluolsulfamids. Berichte der Deutschen Chemischen Gesellschaft zu Berlin. 1879; 12: 469–73. https://doi.org/10.1002/cber.187901201135

  • Flatz G and Rothauwe HW. Evidence against nutritional adaptation of intolerance of lactose. Humangenetik. 1971; 13(2):118–25. https://doi.org/10.1007/BF00295793 PMid:5114667

  • Artificial sweeteners: No calories…sweet! FDA (Food and Drug Administration); 2006. Available from https://fda.gov/fdac/features/2006/406_sweeteners.html

  • Fry J. The world market for intense sweeteners. World Review of Nutrition and Dietetics. 1999; 85: 201–11. https://doi.org/10.1159/000059691

  • Gandhi M. Here are 5 unbeatable benefits of jaggary (aka gur). India Today. 24th December. 2015.

  • Ghanta S, Banerjee A, Poddar A and Chattopadhyay S. Oxidative DNA damage preventive activity and antioxidant potential of Stevia rebaudiana (Bertoni), a natural sweetener. Journal of Agriculture and Food Chemistry. 2007; 55(26): 10962-7. https://doi.org/10.1021/jf071892q PMid:18038982

  • Goldman RD. Honey for treatment of cough in children. Canadian Family Physician. 2014; 60(12): 1107–10. PMid:25642485 PMCid:PMC4264806

  • Goldsmith LA and Merkel C. Sucralose. Alternative Sweeteners (Nabors OL, ed.). New York, USA: Marcel Dekker, Inc; 2001. p. 185–207. PMid:11878887

  • Gratzer W. Light on sweetness: the discovery of aspartame. Eurekas and Euphorias: The Oxford Book of Scientific Anecdotes. Oxford University Press. 2002. p. 32. PMCid:PMC117092

  • Griffith RTH. The hymns of Atharvaveda. 2nd Edition. Varanasi, India: EJ Lazarus and Co. 1896; 2. PMid:20755995 PMCid:PMC2406265

  • Grivet L, Daniels C, Glaczmann JC, and D’Hont A. A review of recent molecular genetics evidence of sugarcane evolution and domestication. Ethnobotany Research and Application. 2004; 2: 9–17. https://doi.org/10.17348/era.2.0.9-17

  • Hunisigi G. Production of sugarcane: theory and practice. Berlin, Germany: Springer-Verlag; 1993. https://doi.org/10.1007/978-3-642-78133-9

  • Jenkins GH. Introduction to cane sugar technology. Elsevier. 2013. p. 486.

  • Jones G. Stevia. NebGuide. Institute of Agriculture and Natural Resources, University of Nebraska-Lincoln. NE, USA. Feb 2014.

  • Kosmin PJ. The land of the elephant kings: space, territory, and ideology in the Seleucid Empire. Harvard, USA: Harvard University Press; 2014. https://doi.org/10.4159/harvard.9780674416161 PMCid:PMC4200895

  • Kuhn C, Bufe B and Winnig M. Bitter taste receptors for saccharin and acesulfame K. Journal of Neuroscience. 2004; 24: 10260-5. https://doi.org/10.1523/JNEUROSCI.1225-04.2004 PMid:15537898

  • Lee TD. Sweeteners. Kirk-Othmer Encyclopedia of Chemical Technology. USA: John Wiley & Sons, Inc; 2000.

  • Makinen K. Gastrointestinal Disturbances Associated with the Consumption of Sugar Alcohols with Special Consideration of Xylitol: Scientific Review and Instructions for Dentists and Other Health-Care Professionals. International Journal of Dentistry. 2016; 5967907. https://doi.org/10.1155/2016/5967907

  • Malik R. India is the diabetes capital of the world. Mumbai Mirror, 28 January 2016.

  • Mayhew DA, Meyers BI, Stargel WW, Comers CP, Andress SE and Butchko HH. Neotame. In Alternative Sweeteners (Nabors O, Ed.). CRC Press. 2012. p. 133.

  • Mazur RH. Discovery of aspartame. Aspartame Physiology and Biochemistry (Stegink LD and Filer Jr. LJ, Eds.). New York, USA: Dekker; 1984; p. 3–9. PMid:6741139

  • Mercola J and Pearsall K. Sweet deception. Why Splenda®, NutraSweet®, and the FDA may be hazardous to your health. Nashville, TN, USA: Thomas Nelson; 2006.

  • Misra H, Soni M, Silawat N, Mehta D, Mehta BK and Jain DC. Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert. (Bertoni) on alloxan-induced diabetic rats. Journal of Pharmacy and Bioallied Sciences. 2011; 3(2): 242–8. https://doi.org/10.4103/0975-7406.80779 PMid:21687353 PMCid:PMC3103919

  • Molinary S and Quinlan ME. Sucralose. Sweeteners and Sugar Alternatives in Food Technology (Mitchell H, Ed.). Oxford, UK: Blackwell Publishing Ltd; 2006. p. 130–45. https://doi.org/10.1002/9780470996003.ch8

  • Moon HJ, Jeya M, Kim IW and Lee JK. Biotechnological production of erythritol and its applications. Applied Microbiology and Biotechnology. 2010; 86(4): 1017–25. https://doi.org/10.1007/s00253-010-2496-4 PMid:20186409

  • Mullick NP. Honey and beekeeping in the scriptures and after. Indian Bee Journal. 1944; 5-6: 108–14.

  • Nathan DM and Delahanty LM. Beating Diabetes, First Edition. New York, USA: McGraw-Hill; 2005.

  • NFCSF (National Federation of Cooperative Sugar Factories). Ansal Plaza, Block-C, 2nd Floor August Kranti Marg, New Delhi-110049, India. 2018. Available from https://coopsugar.org

  • Noda K, Nakayama K and Oku T. Serum glucose and insulin levels and erythritol balance after oral administration of erythritol in healthy subjects. European Journal of Clinical Nutrition. 1994; 48(4): 286–92. PMid:8039489

  • Nofre C and Tinti J-M. Neotame: discovery, properties, utility. Food Chemistry. 2000; 69(3): 245057. https://doi.org/10.1016/S0308-8146(99)00254-X

  • O’Donnell K. Carbohydrates and intense sweeteners. Chemistry and Technology of Soft Drinks and Fruit Juices, 2nd edn, (Ashurst PR, Ed.). Palese, Hereford, UK: Blackwell Publishing Ltd; 2005; p. 68–89.

  • Parthasarthy N. Origin of noble sugarcanes (Saccharum officinarum). Nature. 1948; 161: 608.

  • Prasad R. Historical aspects of milk consumption in south, southeast, and East Asia. Asian Agri-History. 2017; 21(4): 287–307.

  • Prasad R, YS Shivay and YL Nene. Asia’s contribution to the evolution of agriculture: creativity, history, and mythology. Asian Agri-History. 2016; 20(4): 233–50.

  • Quezada-Calvillo R, Robayo CC and Nichols BL. Carbohydrate Digestion and Absorption. Saunders, Missouri, USA: Elsevier; 2006. PMCid:PMC1449008

  • Remsen I and Fahlberg C. On the oxidation of substitution products of aromatic hydrocarbons. IV. - On the oxidation of ortho toluene sulphamide. American Chemical Journal. 1880; 1(6): 426–39.

  • Renwick AG, Thompson JP, O’Shaughnessy M and Walter EJ. The metabolism of cyclamate to cyclohexylamine in humans during long-term administration. Toxicology and Applied Pharmacology. 2004; 96: 367–80. https://doi.org/10.1016/j.taap.2004.01.013 PMid:15094307

  • Riley P, Moore D, Ahmed F, Sharif MO and Worthington HV. Can xylitol used in products like sweets, candy, chewing gum and toothpaste help prevent tooth decay in children and adults? Cochrane Database of Systematic Reviews 2015; (3): CD010743. https://doi.org/10.1002/14651858.CD010743

  • Saad A, Khan FA, Hayee A and Nazir MS. A review of potential toxicity of artificial sweeteners vs safety of Stevia, a natural bio-sweetener. Journal of Biology, Agriculture and Healthcare. 2014; 4(15). ISSN 2224-3208 (paper) ISSN 2225-093X (online).

  • Sampath Kumar KP, Bhowmick D, Chiranjib Biswajit and Chandira MR. Medicinal uses and health benefits of honey: an overview. Journal of Chemical and Pharmaceutical Research. 2010; 2: 385–95.

  • Santos NC, de Araujo LM, De Luca Canto G, Guerra EN, Coelho MS and Borin MF. Metabolic effects of aspartame in adulthood: A systematic review and metaanalysis of randomized clinical trials. Critical Reviews in Food Science and Nutrition. 2017; 10: 1–14. https://doi.org/10.1080/10408398.2017.1304358

  • Sathyavathi A, Bhoja Raju P, Bupesh KV and Naga Ravi Kiran T. Neotame: high intensity low caloric sweetener. Asian Journal of Chemistry. 2010; 22(7): 5792–6.

  • Shindou T, Sasaki Y, Miki H, Eguchi T, Hagiwara K and Ichikawa T. Determination of erythritol in fermented foods by high performance liquid chromatography. Shokuhin Eiseigaku Zasshi. 1988; 29(6): 419–22. https://doi.org/10.3358/shokueishi.29.419

  • Simoons FJ. Primary adult lactose intolerance and the milking habit: a problem in biological and cultural interaction. 1. Review of the medical research. American Journal of Digestive Diseases. 1969; 14(12): 819–36. https://doi.org/10.1007/BF02233204

  • Singh SD and Rao GP. Stevia: The herbal sugar of the 21st century. Sugar Technology. 2005; 7: 17–24. https://doi.org/10.1007/BF02942413

  • Sreenivasan TV. Inspiring indigenous sugarcanes of India. Sugar Technology. 2004; 6(3): 107–11. https://doi.org/10.1007/BF02942710

  • Stenhouse J. Examination of the proximate principles of some of the lichens. Philosophical Transactions of the Royal Society, London, UK. 1848; 138: 63–89. https://doi.org/10.1098/rstl.1848.0004

  • Takahashi K, Matsuda M, Ohashi K, Taniguchi K, Nakagomi O, Abe Y, Mori S, Okutani NK and Shigeta S. Analysis of anti-rotavirus activity of extract from Stevia rebaudiana. Antiviral Research. 2001; 49(1): 15–24. https://doi.org/10.1016/S0166-3542(00)00134-0

  • Tarbuzani DM, Ahmed SEB and Abu-Tarbouch HM. Chemical composition, minerals and antioxidants of the heart of date palm for three Saudi cultivars. Food and Nutrition Science. 2014; 5: 1379–86. https://doi.org/10.4236/fns.2014.514150

  • Tewari D, Mocan A, Parvanov ED, Sah AN, Nabavi SM, Huminiecki L, Ma ZF, Lee YY, Horbanczuk JO and Atanasov AG. Ethnopharmacological approaches for therapy of jaundice: Part I. Frontiers in Pharmacology. 15 Aug 2017; 8:518. https://doi.org/10.3389/fphar.2017.00518

  • Tewari D, Mocan A, Parvanov ED, Sah AN, Nabavi SM, Huminiecki L, Ma ZF, Lee YY, Horbanczuk JO and Atanasov AG. Ethnopharmacological approaches for therapy of jaundice: Part II. Highly used plant species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae and Fabaceae families. Frontiers in Pharmacology. 10 Aug 2017 10; 8:519. https://doi.org/10.3389/fphar.2017.00519

  • Thomas JE and Glade MJ. Stevia: it’s not just calories. Open Obesity Journal 2010; 2(1): 101–9. https://doi.org/10.2174/1876823701002010101

  • van den Berg A, Timothy P and Mark I. Sugar Profiles of Maple Syrup Grades. Maple Syrup Digest. 2006; 12-13.

  • Vasudevan DM. Textbook of biochemistry for medical students. New Delhi, India: Jaypee Brothers Medical Publishers (P) Ltd.; 2013.

  • Vinutha KS, Rayaprolu L, Yadagiri K, Umakanth AV and Srinivasa Rao P. Sweet Sorghum Research and Development in India: Status and Prospects. Sugar Technology. 2014; 16(2): 133–43. https://doi.org/10.1007/s12355-014-0302-9

  • Volksen W. Die Entdeckung der Starkeverzuckerung (Saurehydrolyse) durch G.S.C. Kirchhoff im Jahre 1811.1949. https://doi.org/10.1002/star.19490010203

  • Walford SN. Composition of cane juice. Proceedings South African Sugar Technologists Association. 1996; 70: 265–6.

  • WHO (World Health Organization). Global health Report on Diabetes 2016. World Health Organization; Geneva 27, Switzerland; 2016.

  • White Jr JW and Doner LW. Honey composition and properties. Pages 82-91 in Beekeeping in the United States. U.S. Department of Agriculture (USDA). Agriculture Handbook No. 335. (Revised). 1980; p. 193.

  • Whitehouse C, Boullata J and McCauley L. The potential toxicity of artificial sweeteners. American Association of Occupational Health Nurses Journal. 2008; 56: 251–9. https://doi.org/10.3928/08910162-20080601-02

  • Wiet SG and Beyts PK. Sensory characteristics of sucralose and other high intensity sweeteners. Journal of Food Science. 1992; 57: 1014–9. https://doi.org/10.1111/j.1365-2621.1992.tb14345.x

  • Yoshida S. Studies on the production of sweet substances in Stevia rebaudiana: I. Simple determination of sweet glycosides in Stevia plant by thin-layer chromato scanner and their accumulation patterns with plant growth. Japanese Journal of Crop Science. 1986; 55(2): 189–95. https://doi.org/10.1626/jcs.55.189

  • Yuval I, Jones BL, Ingram CJE, Swallow DM and Thomas MG. A world wide correlation of lactose persistence phenotypes and genotypes. BMC Evolutionary Biology. 2010; 10: 36. https://doi.org/10.1186/1471-2148-10-36


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  • Sweeteners: From Ancient to Modern Times

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Authors

Rajendra Prasad
6695 Meghan Rose Way, East Amherst, NY 14051, United States

Abstract


Honey was the first sweetener to be discovered by humans in the ancient times. It remained the main sweetener in Europe until Alexander the Great’s visit to India in 326 BCE, when he came across the sweet-juice-producing sugarcane. Sugarcane originated in India during the Vedic period (1200–1000 BCE), and even today, most of the sugarcane grown all over the world has some genetic linkage to the ‘Noble’ canes bred at the Sugarcane Breeding Institute of the Indian Council of Agricultural Research (ICAR-SBI), India. The technology for making sugar from sugarcane juice was also first developed in India. The word sugar, as well as Saccharum, the generic name for sugarcane, are derived from the Sanskrit word sharkara. Sugar beet as a source of sugar was identified in Europe in the middle of the 18th century. Production of sugar syrups started much later. In recent times, the excess consumption of sugar and modern sedentary lifestyles created the problem of diabetes, triggering the search for non-sugar sweeteners. Saccharin, the world’s first and widely used artificial sweetener was accidentally discovered in 1879 in Germany. It was followed by the discovery of other artificial sweeteners, such asaspartame (APM), cyclamate, sucralose, acesulfame-k and neotame, which have been approved by different government authorities and are being marketed in many countries. Nevertheless, when taken in amounts more than the medically approved levels, they may cause health problems. This has made man turn back to Nature once again and search for natural non-sugar sweeteners. The most acceptable natural non-sugar sweetener today is ‘Stevia’, which had been known to people in South America since ages. Stevia is gaining popularity all over the world, and is reported to have antioxidant, antiviral, anti-hypertension, and anti-inflammatory properties. The two alcohol sweeteners erythritol and xylitol can also be considered as natural, since they are produced from natural products. Erythritol is produced from fermented fruits and foods, while xylitol is produced from hemicelluloses from hardwood. Yet another natural sweetener, licorice (mulethi), is mostly used as a flavoring agent and for medicinal purposes. Licorice, aspartame and cyclamate have nearly the same calorie value as sucrose, while xylitol has 63% calorie value as compared with sucrose. The rest of the non-sugar sweeteners are calorie-free.

Keywords


Acesulfame-k, Aspartame, Cyclamate, Diabetes, Honey, Licorice, Neotame, Saccharine, Stevia, Sucralose, Sucrose, Sugarcane, Sugar Beet.

References