Asian Journal of Chemistry and Pharmaceutical Sciences

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A strategy based on sequential design of experiments (screening, optimization and confirmation) was used to develop a tablet formulation of ibuprofen (400 mg) that is manufactured by direct compression. This formulation has a high content of ibuprofen (76%), in spite of the poor flowability of the drug substance. Sequential design of experiments proved to be an effective and efficient strategy in formulation development.

Keywords

Central-Composite Design, Design Of Experiments, Direct Compression, Ibuprofen, Simplex-Screening Design.
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