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Therapeutic Role of Ginkgo biloba Leaf Extract


Affiliations
1 Department of Food and Nutrition, College of Home Science, Dr. Rajendra Prasad Central Agricultural University, Pusa, Samastipur (Bihar), India
2 Department of Food and Nutrition, College of Home Science, Maharana Pratap Agricultural University and Technology, Udaipur (Rajasthan), India
     

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In the past decade, interest by the general public in the use of herbal dietary supplements has risen exponentially. As throughout history, individuals are now turning to the use of “natural” therapies for the prevention, treatment and cure of almost every ailment and aging malady. One of the most popular herbal supplements is Ginkgo biloba leaf extract, taken for its perceived “memory enhancing” properties. Its purported biological effects include: scavenging free radical; lowering oxidative stress; reducing neural damages, reducing platelets aggregation; anti- inflammation; anti-tumor activities; and anti-aging. Clinically, it has been prescribed to treat central nervous system disorders such as Alzheimer’s disease and cognitive deficits. It exerts allergy and changes in bleeding time. There are no standards or guidelines regulating the constituent components of Ginkgo biloba leaf extract nor is exposure limits imposed. The use of Ginkgo leaf extract may be promising for treatment of certain conditions, although its long-term use still needs to be evaluated.

Keywords

Ginkgo biloba, Gingko Leaf Extracts, Terpenoids, Flavonoids, Ginkgolide.
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  • Abad, M.J., Bedoya, L.M. and Bermejo, P. (2010). An update on drug interactions with the herbal medicine Ginkgo biloba. Curr. Drug Metab., 11(2) : 171-182.

  • Abdel-Kader, R., Hauptmann, S., Keil, U., Scherping, I., Leuner, K., Eckert, A. and Müller, W.E. (2007). Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761). Pharmacol. Res., 56 : 493-502.

  • Aruna, D. and Naidu, M.U. (2007). Pharmacodynamic interaction studies of Ginkgo biloba with cilostazol and clopidogrel in healthy human subjects. Br. J. Clin. Pharmacol., 63 : 333-338.

  • Atmaca, M., Tezcan, E., Kuloglu, M., Ustundag, B. and Kirtas, O. (2005). The effect of extract ofGinkgo biloba addition to olanzapine on therapeutic effect and antioxidant enzyme levels in patients with schizophrenia. Psychiatry Clin Neurosci., 59 : 652-656.

  • Bastianetto, S., Ramassamy, C., Dore, S., Christen, Y., Poirier, J. and Quirion, R. (2000). The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta- amyloid. Eur. J. Neurosci., 12:1882-1890.

  • Bate, C., Tayebi, M. and Williams, A. (2008). Ginkgolides protect against amyloid-β1–42-mediated synapse damage in vitro. Mol. Neurodegen., 3: 1-9.

  • Benjamin, J., Muir, T., Briggs, K. and Pentland, B. (2001).A case of cerebral haemorrhage—can Ginkgo biloba be implicated? Postgrad Med. J., 77 : 112-3.

  • Bilia, A. (2002). Ginkgo biloba L. Fitoterapia, 73:276-279.

  • Bone, K.M. (2008). “Potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs: what is the evidence?” Mol. Nutr. Food Res., 52 (7): 764-771.

  • Carlson, J.J., Farquhar, J.W., DiNucci, E, Ausserer, L., Zehnder, J., Miller, D., Berra, K., Hagerty, L. and Haskell, W.L. (2007). Safety and efficacy of a Ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults. J. Am. Diet Assoc., 107:422-432.

  • Chan, P.C., Xia, Q. and Peter, P.F. ( 2007). Ginkgo biloba leave extract: Biological, medicinal and toxicological effects. J. Environ. Sci. & Health Part C, 25 : 211-244.

  • DeFeudis, F.V. (2002). Bilobalide and Neuroprotection. Pharmacol. Res., 46 : 565-568.

  • DeFeudis, F.V., Papadopoulos, V. and Drieu, K. (2003).Ginkgo biloba extracts and cancer: a research area in its infancy. Fundam Clin. Pharmacol, 17 : 405-417.

  • DeFeudis, F.V. and Drieu, K. (2004). "Stress-alleviating" and "vigilance-enhancing"actions of Ginkgo biloba extract (EGb 761).Drug Development Res., 62 : 1-25.

  • De Smet, P.A. (2002). Herbal remedies. N. Engl. J. Med., 347 : 2046-2056.

  • Diamond, B.J., Shiflett, S.C., Feiwel, N., Matheis, R.J., Noskin, O., Richards, J.A. and Schoenberger, N.E. (2000). Ginkgo biloba extract: mechanisms and clinical indications. Arch. Phys. Med. Rehabil., 81:668-678.

  • Donfrancesco, R. and Ferrante, L. (2007). Ginkgo biloba in dyslexia: a pilot study. Phytomedicine, 14 : 367-370.

  • Gertz, H.J. and Kiefer, M. (2004). Review aboutGinkgo biloba special extract EGb 761 (Ginkgo).Curr. Pharm. Des., 10 : 261-264.

  • Gohil, K. and Packer, L. (2002). Global gene expression analysis identifies cell and tissue specific actions of Ginkgo biloba extract, EGb 761. Cell. Mol. Biol., 48 : 625-631.

  • Huang, S.Y., Jeng, C., Kao, S.C., Yu, J.J. and Liu, D.Z. (2004). Improved haemorrheological properties by Ginkgo biloba extract (Egb 761) in type 2 diabetes mellitus complicated with retinopathy. Clinical Nutri., 23(4) : 615-621.

  • Ihl, R., Tribanek, M. and Bachinskaya, N. (2012). Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761(R) in Alzheimer’s disease and vascular dementia: Results from a randomised controlled trial. Pharmacopsychiatry, 45 : 41-46.

  • Koch, E. (2005). Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by

  • ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine, 12 : 10-16.

  • Lu, W.J., Huang, J.D. and Lai, M.L. (2006). The effects of ergoloid mesylates and Ginkgo biloba on the pharmacokinetics of ticlopidine. J. Clin. Pharmacol., 46 : 628-634.

  • Mahadevan, S. and Park, Y. (2008). Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. J. Food Sci., 73 : R14-19.

  • Mahady, G.B. (2002). Ginkgo biloba for the prevention and treatment of cardiovascular disease: a review of the literature. J. Cardiovasc Nurs., 16 : 21-32.

  • McKenna, D.J., Jones, K. and Hughes, K. (2001). Efficacy, safety, and use ofGinkgo biloba in clinical and preclinical applications. Altern Ther Health Med., 7:70, 86, 88-90.

  • Mohutsky, M.A., Anderson, G.D., Miller, J.W. and Elmer, G.W. (2006). Ginkgo biloba: evaluation of CYP2C9 drug interactions in vitro and in vivo. Am. J. Ther., 13 : 24-31.

  • Muir, A.H., Robb, R., McLaren, M., Daly, F. and Belch, J.J.F. (2002). The use of Ginkgo biloba in Raynaud’s disease: a doubleblind placebo-controlled trial Vascular Medicine; 7: 265-267

  • Oskoueiet, D.S., Rikhtegar, R., Hashemilar, M., Sadeghi-Bazargani, H., Sharifi-Bonab, M., Sadeghi-Hokmabadi, E., Zarrintan, S. and Sharifipour, E. (2013). The effect of Ginkgo biloba on functional outcome of patients with acute ischemic stroke: a double-blind, placebo-controlled, randomized clinical trial. J. Stroke Cerebrovasc Dis., 22(8) : 557-63.

  • Ramassamy, C., Longpre, F. and Christen, Y. (2007).Ginkgo biloba extract (EGb 761) in Alzheimer’s disease: is there any evidence? Curr. Alzheimer Res., 4 : 253-262.

  • Sagar, S.M., Yance, D. and Wong, R.K. (2006).Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1. Curr. Oncol., 13:14-26.

  • Sener, G., Sehirli, O., Tozan, A., Velioglu-Ovunc, A., Gedik, N. and Omurtag, G.Z. (2007).Ginkgo biloba extract protects against mercury (II)-induced oxidative tissue damage in rats. Food Chem. Toxicol., 45 (4) : 543-550.

  • Smith, J.V. and Luo, Y. (2003). Elevation of oxidative free radicals in Alzheimer’s disease models can be attenuated byGinkgo biloba extract EGb 761. J. Alzheimer’s Dis., 5 : 287-300

  • Smith, J.V. and Luo, Y. (2004). Studies on molecular mechanisms of Ginkgo biloba extract. Appl. Microbiol. Biotechnol., 64 : 465-472.

  • Snitz, B.E., O’Meara, E.S., Carlson, M.C., Arnold, A.M., Ives, D.G., Rapp, S.R., Saxton, J., Lopez, O.L., Dunn, L.O., Sink, K.M. and DeKosky, S.T. (2009). Ginkgo biloba for preventing cognitive decline in older adults: A randomized trial. JAMA, 302 : 2663-2670.

  • Sohn, M. and Sikora, R. (1991). Ginkgo biloba extract in the therapy of erectile dysfunction. J. Sex Edu. & Therapy, 17(1) : 53-61.

  • Sun, G. and Liu, J. (2007). Qualitative and quantitative assessment of the HPLC fingerprints of Ginkgo biloba extract by the involution similarity method. Anal Sci., 23 : 955-958.

  • Tang, J., Sun, J., Zhang, Y., Li, L., Cui, F. and He, Z. (2007). Herb-drug interactions: Effect of Ginkgo biloba extract on the pharmacokinetics of theophylline in rats. Food Chem. Toxicol., 12 : 2441-2445.

  • Van Beek, T.A. and Montoro, P. (2009). Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceutical. J. Chromatography A., 1216 (11): 2002-2032.

  • Woelk, H., Arnoldt, K.H., Kieser, M. and Hoerr, R. (2007). Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial. J. Psychiatr Res., 41 : 472-480.

  • Yao, Z.X., Han, Z., Drieu, K. and Papadopoulos, V. (2004). Ginkgo biloba extract (Egb 761) in- hibits beta-amyloid production by lowering free cholesterol levels. J. Nutr. Biochem., 15 : 749-756.

  • Zimmermann, M., Colciaghi, F., Cattabeni, F., Di Luca, M. (2002). Ginkgo biloba extract: from molecular mechanisms to the treatment of Alzheimer’s disease. Cell Mol. Biol., 48 : 613-623.


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  • Therapeutic Role of Ginkgo biloba Leaf Extract

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Authors

Gitanjali
Department of Food and Nutrition, College of Home Science, Dr. Rajendra Prasad Central Agricultural University, Pusa, Samastipur (Bihar), India
Renu Mogra
Department of Food and Nutrition, College of Home Science, Maharana Pratap Agricultural University and Technology, Udaipur (Rajasthan), India

Abstract


In the past decade, interest by the general public in the use of herbal dietary supplements has risen exponentially. As throughout history, individuals are now turning to the use of “natural” therapies for the prevention, treatment and cure of almost every ailment and aging malady. One of the most popular herbal supplements is Ginkgo biloba leaf extract, taken for its perceived “memory enhancing” properties. Its purported biological effects include: scavenging free radical; lowering oxidative stress; reducing neural damages, reducing platelets aggregation; anti- inflammation; anti-tumor activities; and anti-aging. Clinically, it has been prescribed to treat central nervous system disorders such as Alzheimer’s disease and cognitive deficits. It exerts allergy and changes in bleeding time. There are no standards or guidelines regulating the constituent components of Ginkgo biloba leaf extract nor is exposure limits imposed. The use of Ginkgo leaf extract may be promising for treatment of certain conditions, although its long-term use still needs to be evaluated.

Keywords


Ginkgo biloba, Gingko Leaf Extracts, Terpenoids, Flavonoids, Ginkgolide.

References