Food Science Research Journal

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Effect Of Withania somnifera Extract on Adipose Tissue Derived Progenitors


Affiliations
1 Department of Animal Biotechnology, Centre for Stem Cell Research and Regenerative Research, Madras Veterinary College, Vepery, Chennai (T.N.), India
2 Department of Food Science and Technology, College of Food and Dairy Technology, Tamil Nadu Veterinary and Animal Sciences University, Chennai (T.N.), India
     

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Herbs play an important role in the traditional systems of medicine and have been used in medical practices since olden days. Herbs have the potential to act as therapeutic agents against various human diseases.The present research is designed based on the concept on the use of herbal adaptogen (Withania somnifera) to combat contemporarily increasing stress related disorders.The proliferative and differentiation properties of stem cells treated with herbal extracts have shown promise in diseases such as osteoporosis, neurodegenerative disorders and other tissue degenerative disorders (Bickford et al., 2006). These herbs help to balance cortisol levels which are associated with healthy energy levels and help the body to maintain restful sleep at appropriate times (Kaur et al., 2004). These adaptogens boost the immune system and improves the general wellbeing and slows down the aging process and revitalizes the entire body by stimulating the production of stem cells (Bhattacharya and Muruganandam, 2003). The aim of the research work is to assess the proliferative potential of Indian adaptogenic herb namely Withania somnifera on adipose tissue derived cells from Indian dogs.

Keywords

Withania Somnifera,adipose Tissue, Derived Progenitors.
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  • Archana, R. and Namasivayam, A. (1999). Antistressor effect ofWithania somnifera. J. Ethanopharmacol., 64: 91-93.

  • Bhattacharya, S.K. and Muruganandam, A.V. (2003). Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacology Biochemistry & Behavior., 75(3):547-555.

  • Bickford, P.C., Tan, J., Shytle, R.D., Sanberg, C.D., Badri, N.E. and Sanberg, P.R. (2006). Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells & Development,15: 118-123.

  • Hasan, N.M. and Al-Sorkhy, M.K. (2014). Herbs that promote cell proliferation. Internat. J. Herbal Med.,1(6):18-21.

  • Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K. and Kaul, S.C. (2004). Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Food & Chemical Toxicology, 42 (12) : 2015-2020.


Abstract Views: 244

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  • Effect Of Withania somnifera Extract on Adipose Tissue Derived Progenitors

Abstract Views: 244  |  PDF Views: 0

Authors

A. Mangala Gowri
Department of Animal Biotechnology, Centre for Stem Cell Research and Regenerative Research, Madras Veterinary College, Vepery, Chennai (T.N.), India
S. Priya
Department of Food Science and Technology, College of Food and Dairy Technology, Tamil Nadu Veterinary and Animal Sciences University, Chennai (T.N.), India
D. Baskaran
Department of Food Science and Technology, College of Food and Dairy Technology, Tamil Nadu Veterinary and Animal Sciences University, Chennai (T.N.), India

Abstract


Herbs play an important role in the traditional systems of medicine and have been used in medical practices since olden days. Herbs have the potential to act as therapeutic agents against various human diseases.The present research is designed based on the concept on the use of herbal adaptogen (Withania somnifera) to combat contemporarily increasing stress related disorders.The proliferative and differentiation properties of stem cells treated with herbal extracts have shown promise in diseases such as osteoporosis, neurodegenerative disorders and other tissue degenerative disorders (Bickford et al., 2006). These herbs help to balance cortisol levels which are associated with healthy energy levels and help the body to maintain restful sleep at appropriate times (Kaur et al., 2004). These adaptogens boost the immune system and improves the general wellbeing and slows down the aging process and revitalizes the entire body by stimulating the production of stem cells (Bhattacharya and Muruganandam, 2003). The aim of the research work is to assess the proliferative potential of Indian adaptogenic herb namely Withania somnifera on adipose tissue derived cells from Indian dogs.

Keywords


Withania Somnifera,adipose Tissue, Derived Progenitors.

References