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Current Information on Capsicum frutescens: A Critical Review of Pharmacological Potential


Affiliations
1 Department of Biochemistry, The Institute of Science, 15, Madam Cama Road, Mumbai - 400 032, India
2 The Institute of Forensic Science, 15, Madam Cama Road, Mumbai - 400 032, India
     

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Capsicum frutescens is a species of the Solanaceae family of the genus Capsicum, which has around 20 species, five of which are regularly cultivated: “Capsicum annuum, Capsicum baccatum, Capsicum chinense, Capsicum frutescens, and Capsicum pubescens.” Since ancient times, C. frutescens has been used to taste and colour food all throughout the world. However, it is also employed for its medical benefits by many civilizations all over the world. This prompted researchers to concentrate on its chemical components, which led to a number of studies. The components isolated from C. frutescens such as capsaicinoids, carotenoids, and saponins authenticated its antibacterial, antidiabetic, anti-fungal, cardiovascular, thrombolytic, anti-cancer, and anti-oxidant activities along with a few more through various studies. This review focuses on all the pharmacological properties of these components highlighting the significance of Capsicum frutescens in herbal medicine.


Keywords

Capsicum frutescens, Bird Chili, Solanaceae, Pharmacological Potential, Anti-Oxidant.
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  • Shah, V.V., Shah, N.D. and Patrekar, P.V. Medicinal plants from Solanaceae family research. J. Pharm. Technol., 2013, 6, 143-151.

  • Darkwah, W.K., Koomson, D.A., Miwornunyuie, N., Nkoom, M. and Puplampu, J.B. Review: Phytochemistry and medicinal properties of Solanum torvum fruits. All Life, 2020, 13, 498-506. doi:10.1080/26895293.2020.1817799

  • Ng, T.B., Ngai, P.H.K., Cheung, R.C.F., et al. Antifungal and mitogenic activities of cluster pepper (Capsicum frutescens) seeds. Nuts and Seeds in Health and Disease Prevention, 2011, 345-349. doi:10.1016/B978-0-12-375688-6.10041-6

  • Rahim, R. and Mat, I. Phytochemical contents of Capsicum frutescens ( Chili Padi ), Capsicum annum ( Chili Pepper ) and Capsicum annum ( Bell Peper ) aqueous extracts. Int. Conf. Biol. Life Sci., 2012, 40, 164-167.

  • Islam, M.S. and Choi, H. Red chilli and type 2 diabetes dietary red chilli (Capsicum frutescens L.) is insulinotropic rather than hypoglycemic in type 2 diabetes model of rats. Phytotherapy Res., 2008, 22, 1025-1029. doi:10.1002/ptr

  • Limcy, T.J.L.T.J. and Sripathi, S.K. Ethno Medicinal practices of tribal inhabitants of Attappady and Vakkodan hill regions of Kerala. Int. J. Sci. Res., 2012, 2, 33-36. doi:10.15373/22778179/mar2013/12

  • Nascimento, P.L.A., Nascimento, T.C.E.S., Ramos, N.S.M., et al. Quantification, antioxidant and antimicrobial activity of phenolics isolated from different extracts of Capsicum frutescens (Pimenta Malagueta). Molec., 2014, 19, 5434-5447. doi:10.3390/molecules19045434

  • Lima, M.F., Carvalho, S.I.C., Ragassi, C.F., Bianchetti, L.B., Faleiro, F.G. and Reifschneider F.J.B. Characterization of a pepper collection (Capsicum frutescens L.) from Brazil. Genet. Molec. Res., 2017, 16. doi:10.4238/gmr16039704

  • Shim, D., Raveendar, S., Lee, J.R., Lee, G.A., Ro, N.Y., Jeon, Y.A., Cho, G.T., Lee, H.S., Ma, K.H. and Chung, J.W. The complete chloroplast genome of Capsicum frutescens (Solanaceae). Appl. Plant Sci., 2016, 4, 1600002. doi:10.3732/apps.1600002

  • Smith, P.G. and Heiser, C.B. Taxonomic and genetic studies on the cultivated peppers, Capsicum annuum L. and C. frutescens L. Am. J. Bot., 1951, 38, 362-368. doi:10.1002/j.1537-2197.1951. tb14835.x

  • Anthony, O. Regulated effects of Capsicum frutescens supplemented diet (C.F.S.D) on fasting blood glucose level, biochemical parameters and body weight in alloxan induced diabetic wistar rats. Br. J. Pharm. Res., 2013, 3, 496-507. doi:10.9734/bjpr/2014/3256

  • Khovidhunkit, W. and Wittayalertpanya, S. Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J. Med. Assoc. Thailand. 2009, 92, 108-113

  • Kuzma, M., Past, T., Mozsik, G. and Perjesi, P. Pharmacobotanical analysis and regulatory qualification of Capsicum fruits and Capsicum extracts- A survey. Capsaicin - Sensitive neural afferentation gastrointest tract from bench to bedside. InTech. 2014. https://doi.org/10.5772/58812

  • Maurya, V.K., Srinvasan, R., Ramesh, N., Anbalagan, M. and Gothandam, K.M. Expression of carotenoid pathway genes in three Capsicum varieties under salt stress. Asian J. Crop Sci., 2015, 7, 286-294. doi:10.3923/ajcs.2015.286.294

  • Schweiggert, U., Kurz, C., Schieber, A. and Carle, R. Effects of processing and storage on the stability of free and esterified carotenoids of red peppers (Capsicum annuum L.) and hot chilli peppers (Capsicum frutescens L.). Eu. Fd. Res. Technol., 2007, 225, 261-270. doi:10.1007/s00217-006-0413-y

  • Pundir, R., Rani, R., Tyagi, S. and Pundir, P. Properties of chili. Int. J. Ayurveda and Pharma Res., 2016, 4, 53-59.

  • Manikharda, Takahashi, M. and Arakaki, M., Yonaminc, K., Asilain, Y., Takara, K. and Wada, K. Physical properties, flavor characteristics and antioxidant capacity of Shimatogarashi (Capsicum frutescens). Fd. Sci.Technol Res., 2017, 23, 427-435. doi:10.3136/fstr.23.427

  • R, M.M., Illuri, R. and Balaji, P. Evaluation of antioxidant potential of Capsicum frutescens. J. Drug Deliv. Therap., 2019, 9, 376-382. http://dx.doi.org/10.22270/jddt.v9i2-s.2531.

  • R, M.M., Illuri, R. and Balaji, P. Investigation of bioactive compounds of Capsicum frutescence and Annona muricata by chromatographic techniques. J. Drug Deliv. Ther., 2019, 9, 485-495. doi:10.22270/jddt.v9i4.3083

  • Stergiopoulou, T., De Lucca, A.J., Meletiadis, J., et al. In vitro activity of CAY-1, a saponin from Capsicum frutescens, against microsporum and trichophyton species. Med. Mycol., 2008, 46, 805-810. doi:10.1080/13693780802089831

  • Raimi, M.M., Shittu, S.A. and Oyetade, O.A. Physicochemical properties and mineral composition of Capsicum annum and Capsicum frutescens oils. IOSR J. Appl. Chem., 2014, 7, 112-116. https://doi.org/10.9790/5736-0711112116.

  • Koffi-Nevry, R., Kouassi, K.C., Nanga, Z.Y., Koussémon, M. and Loukou, G.Y. Antibacterial activity of two bell pepper extracts: Capsicum annuum L. and Capsicum frutescens. Int. J. Fd. Prop., 2012, 15, 961-971. doi:10.1080/10942912.2010.509896

  • Cichewicz, R.H. and Thorpe, PA. The antimicrobial properties of chile peppers (Capsicum species) and their uses in mayan medicine. J. Ethnopharmacol., 1996, 52, 61-70. https://doi.org/10.1016/0378-8741(96)01384-0

  • Gurnani, N., Gupta, M., Mehta, D. and Mehta, B.K. Chemical composition, total phenolic and flavonoid contents, and in vitro antimicrobial and antioxidant activities of crude extracts from red chilli seeds ( Capsicum frutescens L.) . J. Taibah University for Sci., 2016, 10, 462-470. doi:10.1016/j.jtusci.2015.06.011

  • Renault, S., De Lucca, A.J., Boue, S., Bland, J.M., Vigo, C.B. and Selitrennikoff, C.P. CAY-1, a novel antifungal compound from cayenne pepper. Med. Mycol., 2003, 41, 75-82. doi:10.1080/mmy.41.1.75.82

  • De Lucca, A.J., Bland, J.M., Vigo, C.B., et al. CAY-1, a fungicidal saponin from Capsicum sp. fruit. Med. Mycol, 2002, 40, 131-137. doi:10.1080/mmy.40.2.131.137

  • Akiba, Y., Angeles, L., Kato, S., Nakamura, M. and Takeuchi, K. Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet β cells modulates insulin secretion in rats. Biochem. Biophy. Res. Commun., 2004, 321, 219-225. https://doi.org/10.1016/j.bbrc.2004.06.149.

  • Weerapan Khovidhunkit, Supeecha Wittayalertpanya. Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J. Med. Assoc. Thai., 2009, 92, 108-113.

  • Dougnon, T.J. and Gbeassor, M. Evaluation of the effects of the powder of Capsicum frutescens on glycemia in growing rabbits. Vet World, 2016, 9, 281-286. doi:10.14202/vetworld.2016.281-286

  • Perumal, P., Parasuraman, S., Chien, T.S. and Luong, L.Y. Pharmacological evaluation of green chilli induced diabetes. Drug Invent. Today, 2019, 11, 10-20.

  • Patel, D.K., Prasad, S.K., Kumar, R. and Hemalatha, S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac. J. Trop. Biomed., 2012, 2, 320-330. doi:10.1016/S2221-1691(12)60032-X

  • Tolan, I., Ragoobirsingh, D. and Morrison, E.Y.S.A. Isolation and purification of the hypoglycaemic principle present in Capsicum frutescens. Phytoth. Res., 2004, 18, 95-96. doi:10.1002/ptr.1328

  • Kazembe, T. and Makusha, C. Evaluation of mosquito repellencies of Capsicum frutescens, Carica papaya and Cyanodon dactylonextracts and extract mixtures. Bull. Environ. Pharmacol. Life Sci., 2012, 1, 34 - 40.

  • Vinayaka, K.S., PrashithKekuda, T.R., Nandini, K.C., Rakshitha, M.N., Ramya Martis, Shruthi, J., Nagashree, G.R. and Anitha, B. Potent insecticidal activity of fruits and leaves of Capsicum frutescens (L.)var. longa (Solanaceae). Der Pharmacia Lettre, 2010, 2, 172-176.

  • Habte, G. and Assefa, S. In Vivo antimalarial activity of crude fruit extract of Capsicum frutescens Var . Minima ( Solanaceae ) against Plasmodium berghei -infected mice. Bio. Med. Res. Int., 2020. https://doi.org/10.1155/2020/1320952

  • Ling, F., Wang, J. and Lu, C. Effects of aqueous extract of Capsicum frutescens ( Solanaceae) against the fish ectoparasite Ichthyophthirius multifiliis. 2012, 111, 841–848. doi 10.1007/s00436-012-2907-9

  • Caecilia Setiawati,H.M.N., Mantika Octafiyanti, P., Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi, F. Effect of chilli pepper (Capsicum frutescens L.) on the bleeding time, coagulation time, and platelet’s amount of rats.; 2012. International Conference: Research and Application on Traditional Complementary and Alternative Medicine in Health Care (TCAM)., 2012; June, 22nd-23rd 2012 Surakarta Indonesia.

  • Adigun, N.S., Oladiji, A.T. and Ajiboye, T.O. Hydro-Ethanolic fruit extract of Capsicum frutescens reversed Triton-X-100–induced hyperlipidaemia in rats. J. Dietary Suppl., 2020, 17, 53-66. doi:10.1080/19390211.2018.1482982

  • Ahuja, K.D.K. and Ball, M.J. Effects of daily ingestion of chilli on serum lipoprotein oxidation in adult men and women. Br. J. Nutr., 2006, 96, 239-242. doi:10.1079/bjn20061788

  • Hassan, M.H., Edfawy, M., Mansour, A. and Hamed, A. Antioxidant and antiapoptotic effects of capsaicin against carbon tetrachloride-induced hepatotoxicity in rats. Toxicol. Indust. Health., 2012, 28, 428-438. https://doi.org/10.1177/0748233711413801.

  • Erhirhie, E.O. Hepatoprotective effects of Capsicum frutescens supplemented diet against acetaminophen induced liver damage in Wistar rats. Nigerian J. Sci. Environ., 2014, 13, 108-115.

  • Kim, J.H., Lee, J., Kang, S., Moon, H., Chung, K.H. and Kim, K.R. Antiplatelet and antithrombotic effects of the extract of Lindera obtusiloba Leaves. Biomol. Ther (Seoul). 2016, 24, 659-664.

  • Sheikh Anwar, M., Newaz Khan, I., Mominul, M., et al. Thrombolytic and cytotoxic effect of different herbal extracts. IJPSR., 2011, 2, 3118-3121 http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).

  • Emran T. Bin, Rahman, M.A., Uddin, M.M.N., et al. Effects of organic extracts and their different fractions of five Bangladeshi plants on in vitro thrombolysis. BMC Complement Altern Med., 2015, 15. doi:10.1186/s12906-015-0643-2

  • Wei, X., et al. CaPSY1 gene plays likely the key role in carotenoid metabolism of pepper (Capsicum annuum) at ripening. Functional Plant Biol., 48, 141-155. https://doi.org/10.1071/FP19287

  • Wangcharoen, W. Antioxidant capacity changes of bird chili (Capsicum frutescens linn.) during hot air drying. Nat. Sci., 2009, 43, 12 - 20.

  • Oboh, G. and Ogunruku, O.O. Cyclophosphamide-induced oxidative stress in brain: Protective effect of hot short pepper (Capsicum frutescens L. var. abbreviatum). Experimen. Toxicol. Pathol., 2010, 62, 227-233. doi:10.1016/j.etp.2009.03.011

  • Yamada, M. and Ichihara, T. iMedPub journals effects of orally ingested paprika xanthophylls on respiratory metabolism during endurance exercise : Study protocol for an interventional randomised controlled trial. Health Sci. J., 2020, 13, 1-5. doi:10.36648/1791-809X.14.1.694

  • Surh, Y., Lee, E. and Lee, J.M. Chemoprotective properties of some pungent ingredients present in red pepper and ginger. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1998, 402, 259–267. https://doi.org/10.1016/S0027-5107(97)00305-9

  • GA, S. and MS, M. Phytochemical screening, antioxidant activities and in vitro anticancer potential of egyptian Capsicum Spp. Biochem. pharmacol., 2015, 05. doi:10.4172/2167-0501.1000205

  • Dwivedi, V., Shrivastava, R., Hussain, S., Ganguly, C. and Bharadwaj, M. Cytotoxic potential of indian spices ( extracts ) against esophageal squamous carcinoma cells. Asian Pac.J. cancer preven., 2011, 12, 2069-2073.

  • Khan, F.A., Mahmood, T., Ali, M., Saeed, A. and Maalik, A. Pharmacological importance of an ethnobotanical plant: Capsicum annuum L. Natural Prod. Res., 2014, 28, 1267-1274. doi:10.1080/14786419.2014.895723

  • Srinivasan, K. Role of spices beyond food flavoring : Nutraceuticals with multiple health effects. Fd. Rev. Int., 2005, 21, 167–188. doi:10.1081/FRI-200051872

  • Bhattacharya, A., Chattopadhyay, A. and Mazumdar, D. Antioxidant constituents and enzyme activities in chilli peppers. Int. J. Veget. Sci., 2010, 16,201-211. doi:10.1080/19315260903529709

  • Jolayemi, A.T. and Ojewole, J.A.O. Comparative anti-inflammatory properties of Capsaicin and ethyl-aAcetate extract of Capsicum frutescens linn [Solanaceae] in rats. Afr. Healt. Sci., 2013, 13, 357-361. doi:10.4314/ahs.v13i2.23

  • Alabi, A., Ajayi, A.M., Olooto, W.E., Emegoakor, C., Oladunjoye, O. and Obikoya, Y. Antinociceptive and anti-inflammatory properties of a polyherbal extract of Plumbago zeylinica and Capsicum frutescens in rodents. Afr. J. Biomed. Res., 2017, 20, 277-285.

  • Rouhi-boroujeni, H., Rouhi-boroujeni, H., Khoddami, M., Khazraei, H.R., Dehkordi, E.B. adn Rafieian-kopaei, M. Hypolipidemic herbals with diuretic effects : A systematic review. IIOABJ., 2017, 8, 21-28.

  • Maramag, R.P. Diuretic potential of Capsicum frutescens linn., Corchorus oliturius linn., and Abelmoschus esculentus linn. As. J. Nat. Appl. Sci., 2013, 2, 60-69.

  • Dass, S. and Deka, S.A.l. A preclinical study on gastric ulcer protective activity of world’s hottest chilli Capsicum frutescenes. J. Clin. Diagn. Res., 2008, 2, 1024-1027.

  • Omar, O., Bukhari, H., ElSawy, N. and Header, E. Efficacy of Capsicum frutescens in curing the peptic ulcer. Int. J. Pure. Appl. Sci. Technol., 2013, 15, 43-54.

  • Jolayemi, A.T. and Ojewole, J.A.O. Analgesic effects of Capsicum frutescens linn. [Solanaceae] fruit aqueous extract in mice. Global Adv. Res. J. Med. Med. Sci., 2014, 3, 75-86.

  • Gagnier, J.J., Oltean, H., Van Tulder, M.W., Berman, B.M., Bombardier, C. and Robbins, C.B. Herbal medicine for low back pain a cochrane review. Spine, 2016, 41, 116-133. doi:10.1097/BRS.0000000000001310

  • Oltean, H., Robbins, C., Van Tulder, M.W., Berman, B.M., Bombardier, C. and Gagnier, J.J. Herbal medicine for low-back pain. Coch. Datab. Syst. Rev., 2014, 12. doi: 10.1002/14651858.CD004504.pub4

  • Mostafa Kamal, A., Ashfak Ahmed Chowdhury, K., Moazzam Hossen Chy, M., et al. Evaluation of anthelmintic activity of seeds of Sesamum indicum L. and fruits of Capsicum frutescens L. J. Pharmac. Phytochem., 2015, 3, 256-259.


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  • Current Information on Capsicum frutescens: A Critical Review of Pharmacological Potential

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Authors

Meetali Chinnkar
Department of Biochemistry, The Institute of Science, 15, Madam Cama Road, Mumbai - 400 032, India
Pratima Jadhav
The Institute of Forensic Science, 15, Madam Cama Road, Mumbai - 400 032, India

Abstract


Capsicum frutescens is a species of the Solanaceae family of the genus Capsicum, which has around 20 species, five of which are regularly cultivated: “Capsicum annuum, Capsicum baccatum, Capsicum chinense, Capsicum frutescens, and Capsicum pubescens.” Since ancient times, C. frutescens has been used to taste and colour food all throughout the world. However, it is also employed for its medical benefits by many civilizations all over the world. This prompted researchers to concentrate on its chemical components, which led to a number of studies. The components isolated from C. frutescens such as capsaicinoids, carotenoids, and saponins authenticated its antibacterial, antidiabetic, anti-fungal, cardiovascular, thrombolytic, anti-cancer, and anti-oxidant activities along with a few more through various studies. This review focuses on all the pharmacological properties of these components highlighting the significance of Capsicum frutescens in herbal medicine.


Keywords


Capsicum frutescens, Bird Chili, Solanaceae, Pharmacological Potential, Anti-Oxidant.

References