The Indian Journal of Nutrition and Dietetics

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Prevalence and Risk of Osteoporosis and Cardiovascular Disease in Rajasthani Post Menopausal Women


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1 Maharana Pratap University of Agriculture and Technology, Udaipur, Rajasthan - 313 001, India
     

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Osteoporosis and cardiovascular disease (CVD) are a major growing public health problem with impact that crosses medical, social and economic lines. The aim of this study was to assess the prevalence and risk of osteoporosis and CVD in post menopausal women. A cross sectional study was conducted on 322 post menopausal women aged 45-55 years residing in Udaipur city, Rajasthan. Risk of osteoporosis in subjects was assessed using Osteoporosis Self Assessment Tool for Asian (OSTA) and risk of CVD was determined using CVD risk assessment tool. The body weight and age of subjects were calculated for the OSTA index sore. Total cholesterol, high density lipoprotein, diastolic blood pressure and smoking habits of subjects were assessed for CVD risk score. Results of OSTA assessment revealed that 24.22 % respondents were at medium risk of osteoporosis whereas results of CVD assessment showed that a large number of subjects i.e. 82.91 % were at medium risk of CVD. Combining both the assessment scores of subjects, 23.91 % post menopausal women were found at medium risk of both osteoporosis and CVD. Study showed a lower prevalence of osteoporosis having medium risk and higher prevalence of CVD having moderate risk in post menopausal women. The findings suggest that more studies should be done on these at risk population for preventive and therapeutic interventions.

Keywords

Osteoporosis, CVD, Post Menopause, Risk Factors, OSTA, CVD Risk Assessment Tool.
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  • World Health Organization. WHO Scientific group on research on the menopause in the 1990s. Geneva. WHO Technical Report Series., 1996, 866, 1-107.

  • Burger, H.G., Hale, G.E., Robertson, D.M and Dennerstein, L. A review of hormonal changes during the menopausal transition: Focus on findings from the Melbourne women’s midlife health project. Hum. Reprod Update., 2007, 13, 559-565.

  • Raisz, L.G. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J. Clin. Invest., 2005, 115, 3318–3325.

  • Elaine, N. Bones and Skeletal Tissues, Human Anatomy and Physiology, India: Pearson Education Inc. 2006, 193-194.

  • Guyton, C. and Hall, E. Bone and Teeth. In: Textbook of Medical Physiology, India: Elsevior Inc. 2006, 981-982.

  • Turgeon, J.L., Carr, M.C., Maki, P.M., Mendelsohn, M.E. and Wise, P.M. Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: Insights from basic science and clinical studies. Endocr Rev., 2006, 27, 575-605.

  • Paganini, H.A. Hormone replacement therapy and stroke: risk, protection or no effect? Maturitas., 2001, 38, 243-261.

  • Sherwin, B.B. Estrogen and cognitive aging in women. Trends Pharmacol. Sci., 2002, 23, 527-534.

  • Turgeon, J.L., McDonnell, D.P., Martin, K.A. and Wise, P.M. Hormone therapy: Physiological complexity belies therapeutic simplicity. Sci., 2004, 304, 1269-1273.

  • Wise, P.M., Dubal, D.B., Wilson, M.E., Rau, S.W. and Liu, Y. Estrogens: Trophic and protective factors in the adult brain. Front Neuroendocrinol., 2001, 22, 33-66.

  • McCullough, L.D. and Hurn, P.D. Estrogen and ischemic neuroprotection: An integrated view. Trends Endocrinol Metab., 2003, 14, 228-235.

  • Koh, L.K., Sedrine, W.B., Torralba, T.P., Kung, A., Fujiwara, S., Chan, SP. et al. A simple tool to identify Asian women at increased risk of osteoporosis. Osteoporos. Int., 2001, 12, 699-705.

  • Wilson, P.W.F., D’Agostino, R.B., Levy, D., Belanger, A.M., Silbershatz, H. and Kannel, W.B. Prediction of coronary heart disease using risk factor categories. Circulation., 1998, 97, 1837-1847.

  • Sharma, S., Tandon, V.R., Mahajan, A., Kour, A. and Kumar, D. Preliminary screening of osteoporosis and osteopenia in urban women from Jammu using calcaneal QUS. Ind. J. Med. Sci., 2006, 60, 183-9.

  • Marwaha, R.K., Tandon, N., Garg, M.K., Kanwar, R., Narang, A., Sastry, A., Saberwal, K., Bhadra, K. and Mithal, A. Bone health in healthy Indian population aged 50 years and above. Osteoporos. Int., 2011, 22, 2829-2836.

  • Kim, K.H., Lee, K., Ko, Y.J., Kim, S.J., Oh, S.I., Durrance, D.Y., Yoo, D. and Park, S.M. Prevalence, awareness, and treatment of osteoporosis among Korean women: The Fourth Korea National Health and Nutrition Examination Survey. Bone., 2012, 50, 1039-1047.

  • Vestergaard, P., Rejnmark, L. and Mosekilde, L. Osteoporosis is markedly underdiagnosis: A nationwide study from Denmark. Osteoporos. Int., 2005, 16, 134-141.

  • Al-Qutob, R.J., Mawajdeh, S.M., Khalil, A.A., Schmidt, A.B., Hannak, A.O. and Masri, B.K. The magnitude of osteoporosis in middle aged women. Saudi Med. J., 2001, 22, 1109-1017.

  • Abdulbari, B., Mohammed, H. and Mahmoud, Z. Prevalence and predictors of osteoporosis and the impact of life style factors on bone mineral density. J. Rheumatol., 2007, 34, 227-233.

  • Liu, Z., Piao, J., Pang, L., Qing, X., Nan, S., Pan, Z., Guo, Y., Wang, X., Li, F., Liu, J. and Cheng, X. The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China. J. Bone Mineral Metabol., 2002, 20, 181-189.

  • Azizi, F., Emami, H. and Salehi, P. Cardiovascular risk factors in the elderly: The Tehran lipid and glucose study. J. Cardiovasc. Risk., 2003, 10, 65-73.

  • Ebrahimpour, P., Fakhrzahed, H., Heshmat, R., Ghodsi, M., Bandarian, F. and Larijani, B. Metabolic syndrome and menopause: a population-based study. Diabetes and Metabolic Syndrome: Clini. Res. Rev., 2010, 4, 5-9.

  • Bulliyya, G. Risk of coronary heart disease in women after menopause. J. Ind. Med. Assoc., 2001, 99, 478-480,482.

  • Panagiotakos, D.B., Pitsavos, C., Chrysohoou, C., Skoumas, I. and Stefanadis, C. ATTICA Study. Five-year incidence of cardiovascular disease and its predictors in Greece: The ATTICA study. Vasc. Med., 2008, 13, 113-121.

  • Roger, V.L., Go, A.S., Lloyd-Jones, D.M., Benjamin, E.J., Berry, J.D. and Borden, W.B. Heart disease and stroke statistics-2012 update: A report from the American Heart Association. Circulation., 2012, 125, e200–220.

  • Raisz, L.G. Pathogenesis of osteoporosis: Concepts, conflicts, and prospects. J. Clin. Invest., 2005, 115, 3318–3325.

  • Crans, G.G., Silverman, S.L., Genant, H.K., Glass, E.V. and Krege, J.H. Association of severe vertebral fractures with reduced quality of life. Arthritis Rheum., 2004, 50, 4028-4034.

  • Sharma, S., Tandon, V.R. and Mahajan, A. Menopause and cardiovascular disease. J.K. Sci., 2008, 10, 1.

  • Haddock, B.L., Marshak, H.P., Mason, J.J. and Blix, G. The effect of hormone replacement therapy and exercise on cardiovascular disease risk factors in post menopausal women. Sports Med., 2000, 29, 39-49.

  • Bagger, Y.Z., Tanko, L.B., Alexandersen, P., Qin, G. and Christiansen, C. Prospective Epidemiological Risk Factors Study Group. Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip. J. Intern. Med., 2006, 259, 598-605.

  • Collins, T.C., Ewing, S.K., Diem, S.J., Taylor, B.C., Orwoll, E.S., Cummings, S.R., Strotmeyer, E.S. and Ensrud, K.E. Peripheral arterial disease is associated with higher rates of hip bone loss and increased fracture risk in older men. Circulation., 2009, 119, 2305-2312.

  • Farhat, G.N., Cauley, J.A., Matthews, K.A., Newman, A.B., Johnston, J., Mackey, R., Edmundowicz, D. and Sutton, T.K. Volumetric BMD and vascular calcification in middleaged women: The study of women’s health across the Nation. J. Bone Miner. Res., 2006, 21, 1839-46.

  • McFarlane, S.I., Muniyappa, R., Shin, J.J., Bahtiyar, G. and Sowers, J.R. Osteoporosis and cardiovascular disease: Brittle bones and boned arteries, is there a link? Endocrine., 2004, 23, 1-10.

  • Abedin, M., Tintut, Y. and Demer, L.L. Vascular calcification: Mechanisms and clinical ramifications. Arterioscler. Thromb. Vasc. Biol., 2004, 24, 1161–1170.

  • Doherty, T.M., Fitzpatrick, L.A., Inoue, D., Qiao, J.H., Fishbein, M.C., Detrano, R.C., Shah, P.K. and Rajavashisth, T.B. Molecular, endocrine and genetic mechanisms of arterial calcification. Endocr. Rev., 2004, 25, 629-672.


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  • Prevalence and Risk of Osteoporosis and Cardiovascular Disease in Rajasthani Post Menopausal Women

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Authors

Shazia Husain
Maharana Pratap University of Agriculture and Technology, Udaipur, Rajasthan - 313 001, India
Vibha Bhatnagar
Maharana Pratap University of Agriculture and Technology, Udaipur, Rajasthan - 313 001, India

Abstract


Osteoporosis and cardiovascular disease (CVD) are a major growing public health problem with impact that crosses medical, social and economic lines. The aim of this study was to assess the prevalence and risk of osteoporosis and CVD in post menopausal women. A cross sectional study was conducted on 322 post menopausal women aged 45-55 years residing in Udaipur city, Rajasthan. Risk of osteoporosis in subjects was assessed using Osteoporosis Self Assessment Tool for Asian (OSTA) and risk of CVD was determined using CVD risk assessment tool. The body weight and age of subjects were calculated for the OSTA index sore. Total cholesterol, high density lipoprotein, diastolic blood pressure and smoking habits of subjects were assessed for CVD risk score. Results of OSTA assessment revealed that 24.22 % respondents were at medium risk of osteoporosis whereas results of CVD assessment showed that a large number of subjects i.e. 82.91 % were at medium risk of CVD. Combining both the assessment scores of subjects, 23.91 % post menopausal women were found at medium risk of both osteoporosis and CVD. Study showed a lower prevalence of osteoporosis having medium risk and higher prevalence of CVD having moderate risk in post menopausal women. The findings suggest that more studies should be done on these at risk population for preventive and therapeutic interventions.

Keywords


Osteoporosis, CVD, Post Menopause, Risk Factors, OSTA, CVD Risk Assessment Tool.

References





DOI: https://doi.org/10.21048/ijnd.2016.53.2.4302