The Indian Journal of Nutrition and Dietetics

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Dietary Approaches to Prevent Age Related Macular Degeneration:A Review


Affiliations
1 Dept of Ophthalmology, Ram Manohar Lohia Hospital, New Delhi, India
2 Dept of Physiology and Promotive Health, Institute of Home Economics, University of Delhi, New Delhi, India
     

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Age Related Macular Degeneration (ARMD) is the leading cause of irreversible blindness in older adults which has no cure and limited therapeutic options. ARMD may become an increasing concern in the developing countries like India as a result of socio-economic and dietary changes that accompany the economic development1. Diet is potentially one of the most cost effective strategies to prevent the development of end stage condition of ARMD. This review describes the current literature on the role of quality of diet and nutritional supplementation in prevention of advanced ARMD. Various researchers have explored the association between diet, nutrient intake and advanced ARMD. In the Age Related Eye Disease Study (AREDS), use of a daily antioxidant supplementation reduced the rate of progression from intermediate to advanced ARMD by 25% over a period of 5 years and resulted in a 19% reduction in the risk of moderate visual loss2. A high dietary fat intake was reported to be associated with a higher incidence of late ARMD whereas higher intakes of fish or n-3 fatty acids were associated with lower incidence of ARMD3. Chiu et al. reported that quality of dietary carbohydrates influences the risk of ARMD4. But at present, research shows insufficient evidence to recommend dietary modifications and nutritional supplementation in ARMD. Therefore to summarize, the temporal relationship of the diet to advanced ARMD, is a function of the quality of diet. Observational studies suggest that increased dietary intake of omega-3 fatty acids, macular carotenoids, antioxidants and oriental dietary pattern reduces the risk of ARMD whereas, poor dietary carbohydrates quality (as defined by dietary glycemic index) and western dietary pattern may increase the risk of ARMD.

Keywords

Age Related Macular Degeneration (ARMD), Nutritional Supplementation, Carotenoids, Omega-3 Fatty Acids, Glycemic Index.
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  • Popkin, B.M. The nutrition transition: an overview of world patterns of change. Nutr. Rev., 2004, 62, 140 –143.

  • van Leeuwen, R., Boekhoorn, S., Vingerling, J.R. et al. Age related eye disease study research group. A randomized, placebo controlled, clinical trial of high dose supplementation with vitamin C and E, beta carotene and Zinc for age related macular degeneration and vision loss: AREDS report no.8. Arch. Ophthalmol, 2001, 119, 1417-1436.

  • Seddon, J.M., Cote, J. and Rosner, B. Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts and fish intake. Arch. Ophthalmol, 2003, 121, 1728-1737.

  • Chiu, C.J., Milton, C.R., Gensler, G. and Taylor, A. Association between dietary glycemic index and age related macular degeneration in non-diabetic participant in age related eye disease study1,2,3,4. Am. J. Clin. Nutr., 2007, 86, 180-188.

  • Pascolini, D., Mariotti, S.P., Pokharel, G.P. et al. Global update of available data on visual impairment: a compilation of population based prevalence based studies. Ophthalmic Epidemiol., 2004, 11, 67-115.

  • Congdon, N., Colmain, O.B., Klaver, C.C. et al . Causes and prevalence of visual impairment among adults in United States. Arch. Ophtalmol., 2004, 122, 477-485.

  • Krishnan, T.R., Ravindran, D.G., Murthy, V.S., Vashist, P., Fitzpatrick, K.E., Thulasiraj, R.D., John, N., Maraini, G., Camparini, M., Chakravarthy, U. and Fletcher, A.E. PMCID: PMC2868454. Prevalence of early and late age-related macular degeneration in India: The INDEYE Study. Invest. Ophthalmol. Vis. Sci., 2010, 51, 701-707.

  • Bennion, A.E., Shaw, R.L. and Gibson, J.M. What do we know about the experience of age related macular degeneration? Asystematic review and metasynthesis of qualitative research. Soc. Sci. Med., 2012, 75, 976-985.

  • Van Leeuwen, R., Boekhoorn, S., Vingerling, J.R. et al. Dietary intake of antioxidants and risk of age related macular degeneration. JAMA, 2005, 294, 3101-3107.

  • Langenberg, V.G.M., Mares-Perlman, J.A., Klein, R., Klein, B.E., Brady, W.E. and Palta, M. Association between antioxidants and zinc intake and the five year incidence of early age related maculopathy in Beaver Dam Eye Study. Am. J. Epidemiol., 1998, 148, 204-214.

  • Tan, J.S.L., Wang, J.J., Flood, V. et al. Dietary antioxidants and the long term incidence of age - related macular degeneration: The Blue Mountain Eye Study. Ophthalmol., 2008, 115, 334-341.

  • The alpha-tocopheral, beta carotene cancer prevention study group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med., 1994, 330, 1029-1035.

  • Miller, E.R., III, Pastor-Barriuso, R., Dalal, D., Riemersma, R.A., Appei, L.J. and Guallar, E. Meta-analysis: high dose vitamin E supplementation may increase all cause mortality. Ann. Intern. Med., 2005, 142, 37-46.

  • Lonn, E., Bosch, J., Yusuf, S. et al. Effects of long term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 2005, 293, 1338-1347.

  • SanGiovanni, J.P., Chew, E.Y., Clemons, T.E. et al. The relationship of dietary lipid intake and age related macular degeneration in a case -control study: AREDS report no.20. Arch. Ophthalmol., 2007, 125, 671-679.

  • Cho, E., Hung, S., Willet, W.C., Spiegelman, D., Rimm, E.B., Seddon, J.M., Colditz, G.A. and Hankinson, S.E. Prospective study of dietary fat and the risk of age related macular degeneration. Am. J. Clin. Nutr., 2001, 73, 209-218.

  • Weikel, K.A., Chiu, C.J. and Taylor, A. Nutritional modulation of age-related macular degeneration. Mol. Aspects Med., 2012, 33, 318-375.

  • Chiu, C.J., Chang, M.L., Zhang, F.F., Li, T., Gensler, G., Schleicher, M. and Taylor, A. The relation shop of major American dietary patterns to age related macular degeneration. Am. J. Ophtalmol., 2014, 158, 118-127.

  • SanGiovanni, J.P., Chew, E.Y., Agron, E. et al. Age related eye disease study research group. The relationship of dietary omega-3 long -chain polyunsaturated fatty acid intake with incident age related macular degeneration: ARED S report no.23. Arch Ophthalmol., 2008, 126, 1274-1279.

  • Moeller, S.M., Parekh, N., Tinker, L. et al. CAREDS Research Study Group. Associations between intermediate age related macular degeneration and lutein and zeaxanthin in carotenoids in Age Related Eye Disease Study (CAREDS): ancillary study of the Women’s Health Initiative. Arch Ophthalmol., 2006, 124, 1151-1162.

  • Age Related Eye Disease Study Research Group. The relationship of dietary carotenoids and vitamin A, E and C intake with age related macular degeneration in a case - control study : AREDS report no. 22 Arch. Ophthalmol., 2007, 125, 1225-1232.

  • Snow, K.K. and Seddon, J.M. Do age related macular degeneration and cardiovascular disease share common antecedents. Ophthalmic Epidemiol., 1999, 6, 233-240.

  • Chiu, C.J., Hubbard, L.D., Armstrong, J. et al. Dietary glycemic index and carbohydrate in relation to early age related macular degeneration. Am. J. Clin. Nutr., 2006, 83, 880-886.

  • Chiu, C.J., Morris, R.C., Roger, G. et al. Carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacities. Am. J. Clin. Nutr., 2005, 81, 1411-1416.

  • Chiu, C.J., Milton, R.C., Gensler, G. and Taylor, A. Dietary carbohydrate and glycemic index in relation to cortical and nuclear lens opacities in age related eye disease study. Am. J. Clin. Nutr., 2006, 83, 1177-1184.

  • Chiu, C.J., Milton, R.C., Gensler, G. and Taylor, A. Association between dietary glycemic index and age related macular degeneration in non diabetic participants in age related eye disease study1,2,3,4. Am. J. Clin. Nutr., 2007, 86, 1180-1188.

  • Stitt, A.W. The maillard reaction in eye diseases. Ann. N. Y. Acad. Sci., 2005, 1043, 582-597.

  • Kumagai, A.K. Glucose transport in brain and retina: implications in the management and complications of diabetes. Dia. Metab. Res. Rev., 1999, 15, 261-273.

  • Jahngen-Hodge, J., Obin, M.S., Gong, X. et al. Regulation of ubiquitin -conjugating enzymes by glutathione following oxidative stress. J. Biol. Chem., 1997, 272, 28218-28226.

  • Penfold, P.L., Madigan, M.C., Gillies, M.C. and Provis, J.M. Immunological and etiological aspects of macular degeneration. Prog. Retin. Eye Res., 2001, 20, 385-414.

  • Ludwig, D.S. The glycemic index: physiological mechanisms related to obesity, diabetes and cardiovascular disease. JAMA, 2002, 287, 2414-2423.

  • Seddon, J.M., Cote, J. and Rosner, B. Progression of age related macular degeneration: association with dietary fat, transunsaturated fats, nuts and fish intake. Arch. Ophthalmol., 2003, 121, 1728-1737.

  • Biddinger, S.B. and Ludwig, D.S. The insulin -like growth factor axis: a potential link between glycemic index and cancer. Am. J. Clin. Nutr., 2005, 82, 277-278 34. Brand–Miller, J.C., Liu, V., Petocz, P. and Baxter, R.C. The glycemic index of foods influences post prandial insulin-like growth factor -binding protein responses in lean young subjects. Am. J. Clin. Nutr., 2005, 82, 350-354.

  • Shaw, L.C. and Grant, M.B. Insulin - like growth factor-1and Insulin-like growth factor binding protein: their possible role in both maintaining normal retinal vascular function and in promoting retinal pathology. Rev. Endocr. Metab. Disord., 2004, 5, 199-207.


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  • Dietary Approaches to Prevent Age Related Macular Degeneration:A Review

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Authors

Kapur Punam
Dept of Ophthalmology, Ram Manohar Lohia Hospital, New Delhi, India
Pathak Ashok
Dept of Ophthalmology, Ram Manohar Lohia Hospital, New Delhi, India
Suri Manjula
Dept of Physiology and Promotive Health, Institute of Home Economics, University of Delhi, New Delhi, India

Abstract


Age Related Macular Degeneration (ARMD) is the leading cause of irreversible blindness in older adults which has no cure and limited therapeutic options. ARMD may become an increasing concern in the developing countries like India as a result of socio-economic and dietary changes that accompany the economic development1. Diet is potentially one of the most cost effective strategies to prevent the development of end stage condition of ARMD. This review describes the current literature on the role of quality of diet and nutritional supplementation in prevention of advanced ARMD. Various researchers have explored the association between diet, nutrient intake and advanced ARMD. In the Age Related Eye Disease Study (AREDS), use of a daily antioxidant supplementation reduced the rate of progression from intermediate to advanced ARMD by 25% over a period of 5 years and resulted in a 19% reduction in the risk of moderate visual loss2. A high dietary fat intake was reported to be associated with a higher incidence of late ARMD whereas higher intakes of fish or n-3 fatty acids were associated with lower incidence of ARMD3. Chiu et al. reported that quality of dietary carbohydrates influences the risk of ARMD4. But at present, research shows insufficient evidence to recommend dietary modifications and nutritional supplementation in ARMD. Therefore to summarize, the temporal relationship of the diet to advanced ARMD, is a function of the quality of diet. Observational studies suggest that increased dietary intake of omega-3 fatty acids, macular carotenoids, antioxidants and oriental dietary pattern reduces the risk of ARMD whereas, poor dietary carbohydrates quality (as defined by dietary glycemic index) and western dietary pattern may increase the risk of ARMD.

Keywords


Age Related Macular Degeneration (ARMD), Nutritional Supplementation, Carotenoids, Omega-3 Fatty Acids, Glycemic Index.

References





DOI: https://doi.org/10.21048/ijnd.2016.53.2.4304